MR relaxometry of micro-bubbles in the vertical bubbly flow at a low magnetic field (0.2  T)

Arbabi, Aidin; Hall, Joseph W.; Richard, Patrick; Wilkins, Stephen J.; Mastikhin, Igor V.

doi:10.1016/j.jmr.2014.10.001

Cited by 4 publications

(2 citation statements)

References 25 publications

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“…If multiple k-space points are acquired for instance, a combination with the Bayesian analysis by Holland et al might provide a better characterization of the transporting liquid or the transport pathways in the reactor bed 27 . Also, a combination with T Ã 2 weighted imaging as described by Arbabi et al is possible if data is sampled at different echo times 28 . This may also provide a possible way of creating different contrasts for different phases.…”

Section: Discussionmentioning

confidence: 99%

Dynamic magnetic resonance scattering

2019

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Dynamic light scattering is a popular technique to determine the size distribution of small particles in the sub micrometer region. It operates in reciprocal space, by analyzing the signal fluctuations with the photon auto correlation function. Equally, pulsed field gradient magnetic resonance is a technique generating data in the reciprocal space of the density distribution of an object. Here we show the feasibility of employing a magnetic resonance imaging system as a dynamic scattering device similar to dynamic light scattering appliances. By acquiring a time series of single data points from reciprocal space, analogue to dynamic light scattering, we demonstrate the examination of motion patterns of microscopic particles. This method allows the examination of particle dynamics significantly below the spatial resolution of magnetic resonance imaging. It is not limited by relaxation times and covers a wide field of applications for particle or cell motion in opaque media.

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Section: Discussionmentioning

confidence: 99%

Dynamic magnetic resonance scattering

2019

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“…There are several mechanisms through which solutes dissolved in water or materials in contact with water can affect the water proton transverse relaxation rate R 2 ( 1 H 2 O), such as proton exchange, 13 magnetic susceptibility contrast, 14 and compartmentalization of water. 15 All these mechanisms could have contributed, to various extents, to the observed R 2 ( 1 H 2 O) difference between empty and full capsids.…”

Section: ■ Experimental Sectionmentioning

confidence: 99%

Rapid and Noninvasive Quantification of Capsid Gene Filling Level Using Water Proton Nuclear Magnetic Resonance

Taraban

Jones

2021

Anal. Chem.

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The present work reports an enabling novel technology for quantifying the gene content in adeno-associated viral capsids. The method is based on the water proton nuclear magnetic resonance (wNMR) technique. Instead of analyzing the capsid directly, it utilizes water molecules to distinguish empty and full capsids, as water interacts with them differently. The transverse relaxation rate of water protons, R 2 ( 1 H 2 O), readily distinguishes empty and full capsids and is capable of quantifying the fraction of full capsids in a mixture of full and empty ones. It involves no sample preparation and no reagents. Measurement is rapid (data collection takes 1−2 min), noninvasive (the capsid sample can stay inside the original sealed and labeled container to be used in other studies or administered to a patient), and performed using a widebore benchtop NMR instrument. The method can be readily implemented at a production plant for product release as part of product quality control.

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