MR-Proadrenomedullin as biomarker of renal damage in urinary tract infection in children

Penedo, Rafael Peñalver; Lucas, Marta Rupérez; Walther, Luis Antonio Álvarez-Sala; Benavent, Alicia Torregrosa; Losada, María Luisa Casas; Andrío, Luis Bañuelos; Poves, Ana Belén Rebolledo; Campaña, Mercedes Bueno

doi:10.1186/s12887-021-02765-2

Cited by 3 publications

(1 citation statement)

References 37 publications

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“…An MR-proADM level of 1.5–2.0 nmol/L was found to be an independent predictor of MOF-related mortality in adult critically ill patients [ 27 , 31 ]. The cut-off level of MR-proADM for diagnosing kidney damage in urinary tract infections [ 32 ] in children was 0.66 nmol/L, and 0.70 nmol/L was closely related to ICU hospitalization [ 33 ]. Our MR-proADM level of 0.929 nmol/L was slightly higher than reported by the manufacturer and other studies of children [ 32 , 33 ], which may be attributed to the severity of the patients’ illnesses.…”

Section: Discussionmentioning

confidence: 99%

Comprehensive Assessment of Mid-Regional Proadrenomedullin, Procalcitonin, Neuron-Specific Enolase and Protein S100 for Predicting Pediatric Severe Trauma Outcomes

Zakirov,

Petrichuk,

Yanyushkina

et al. 2023

Biomedicines

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The development of multiple organ failure and septic complications increases the cumulative risk of mortality in children with severe injury. Clinically available biochemical markers have shown promise in assessing the severity and predicting the development of complications and outcomes in such cases. This study aimed to determine informative criteria for assessing the severity and outcome prediction of severe injury in children based on levels of mid-regional proadrenomedullin (MR-proADM) procalcitonin (PCT), neuron-specific enolase (NSE), and protein S100. Biomarker levels were measured in 52 children with severe injury (ISS ≥ 16) on the 1st, 3rd, 7th, and 14th days after admission to the ICU. The children were divided into groups based on their favorable (n = 44) or unfavorable (n = 8) outcomes according to the Severe Injury Outcome Scale, as well as their favorable (n = 35) or unfavorable (n = 15) outcomes according to the Glasgow Coma Outcome Scale (GOS). The study also evaluated the significance of biomarker levels in predicting septic complications (with SC (n = 16) and without SC (n = 36)) and diagnosing and stratifying multiple organ failure (with MOF (n = 8) and without MOF (n = 44)). A comprehensive assessment of MR-proADM and PCT provided the highest diagnostic and prognostic efficacy for early diagnosis, risk stratification of multiple organ failure, and outcome prediction in severe injury cases involving children. Additionally, the inclusion of the S100 protein in the study allowed for further assessment of brain damage in cases of traumatic brain injury (TBI), contributing to the overall prognostic model.

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Section: Discussionmentioning

confidence: 99%

Comprehensive Assessment of Mid-Regional Proadrenomedullin, Procalcitonin, Neuron-Specific Enolase and Protein S100 for Predicting Pediatric Severe Trauma Outcomes

Zakirov,

Petrichuk,

Yanyushkina

et al. 2023

Biomedicines

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Effect of Amoxicillin and Clavulanate Potassium Combined with Bazhengsan on Pediatric Urinary Tract Infection

Zhang

Wang

Xu³

2021

Evidence-Based Complementary and Alternative Medicine

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Objective. To explore the therapeutic effect of amoxicillin and clavulanate potassium combined with Bazhengsan on pediatric urinary tract infection (UTI). Methods. The data of 120 UTI children treated in Wuhan Xinzhou District People’s Hospital from February 2019 to February 2020 were retrospectively analyzed. They were equally split into experimental group (EG) and control group (CG) according to the order of admission. All children were treated with amoxicillin and clavulanate potassium for suspension (twice a day), and EG was additionally treated with one dose of Bazhengsan daily. Both groups were treated for 10 days. After treatment, the immune function indexes, inflammatory factor levels, and clinical efficacy were compared before and after treatment. Results. No remarkable differences in the general data such as blood routine and urine routine results were observed between the two groups before treatment ( P > 0.05 ). After treatment, EG achieved obviously better immune function indexes ( P < 0.001 ) and lower levels of inflammatory factors ( P < 0.05 ) compared with CG. Besides, the treatment effective rate in EG (96.7%) was higher than that in CG ( P < 0.05 ). Conclusion. Amoxicillin and clavulanate potassium combined with Bazhengsan can improve the immune function of UTI children and reduce the levels of inflammatory factors, with remarkable effects, which should be popularized in practice.

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A Review of Adrenomedullin in Pediatric Patients: A Useful Biomarker

2022

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Adrenomedullin has several properties. It acts as a potent vasodilator, has natriuretic effects, and reduces endothelial permeability. It also plays a role in initiating the early hyperdynamic phase of sepsis. Since its discovery, many articles have been published studying the uses and benefits of this biomarker. The aim of this review is to determine the usefulness of adrenomedullin in pediatric patients. Relevant studies covering adrenomedullin in pediatrics (<18 years) and published up until August 2021 were identified through a search of MEDLINE, PubMed, Embase, Web of Science, Scopus, and Cochrane. Seventy studies were included in the present review, most of them with a low level of evidence (IV to VI). Research on adrenomedullin has primarily been related to infection and the cardiovascular field. The performance of adrenomedullin to quantify infection in children seems satisfactory, especially in sepsis. In congenital heart disease, this biomarker seems to be a useful indicator before, during, and after cardiopulmonary bypass. Adrenomedullin seems to be useful in the pediatric population for a large variety of pathologies, especially regarding infection and cardiovascular conditions. However, it should be used in combination with other biomarkers and clinical or analytical variables, rather than as a single tool.

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MR-Proadrenomedullin as biomarker of renal damage in urinary tract infection in children

Cited by 3 publications

References 37 publications

Comprehensive Assessment of Mid-Regional Proadrenomedullin, Procalcitonin, Neuron-Specific Enolase and Protein S100 for Predicting Pediatric Severe Trauma Outcomes

Comprehensive Assessment of Mid-Regional Proadrenomedullin, Procalcitonin, Neuron-Specific Enolase and Protein S100 for Predicting Pediatric Severe Trauma Outcomes

Effect of Amoxicillin and Clavulanate Potassium Combined with Bazhengsan on Pediatric Urinary Tract Infection

A Review of Adrenomedullin in Pediatric Patients: A Useful Biomarker

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