MR-Monitored Remitting-Relapsing Pattern of Cortical Involvement in Rasmussen Syndrome: Comparative Evaluation of Serial MR and PET/SPECT Features

Duprez, Thierry; Grandin, Cécile; Gadisseux, Jean-François; Volder, Anne De; Thauvoy, Christian; Keyeux, André; Evrard, Philippe

doi:10.1097/00004728-199711000-00010

Cited by 11 publications

(5 citation statements)

References 15 publications

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“…With interictal and ictal single photon emission computed tomography (SPECT), the same type of results and conclusions have been reached as with PET (English et al, 1989;Hwang et al, 1991;Burke et al, 1992;Buchhalter et al, 1994;Duprez et al, 1997;Geller et al, 1998;Leach et al, 1999;Hartley et al, 2002;Thomas et al, 2003;Chiapparini et al, 2003).…”

Section: Imaging Studies Other Than Morphological Mrimentioning

confidence: 82%

“…PET studies, almost exclusively performed using the tracer fluorodeoxyglucose (FDG), showed abnormalities confined to the affected hemisphere. In most cases, large areas of hypometabolism were observed; in the remainder (mostly 'ictal' studies in patients with ongoing EPC), additional areas of focal hypermetabolism were found (Hajek et al, 1991;Hwang et al, 1991;Tampieri et al, 1991;Caplan et al, 1996;Duprez et al, 1997;Banati et al, 1999;Kaiboriboon et al, 2000;Fiorella et al, 2001;Lee et al, 2001;Chiapparini et al, 2003;Maeda et al, 2003;Shah et al, 2003). In the largest available study (15 patients), FDG-PET changes in early stages (disease duration up to 1 year) were confined to frontotemporal areas.…”

Section: Imaging Studies Other Than Morphological Mrimentioning

confidence: 99%

See 1 more Smart Citation

Pathogenesis, diagnosis and treatment of Rasmussen encephalitis: A European consensus statement

Bien

Granata

Antozzi

et al. 2005

Brain

524

740

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Rasmussen encephalitis (RE) is a rare but severe immune-mediated brain disorder leading to unilateral hemispheric atrophy, associated progressive neurological dysfunction and intractable seizures. Recent data on the pathogenesis of the disease, its clinical and paraclinical presentation, and therapeutic approaches are summarized. Based on these data, we propose formal diagnostic criteria and a therapeutic pathway for the management of RE patients.

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Section: Imaging Studies Other Than Morphological Mrimentioning

confidence: 82%

Section: Imaging Studies Other Than Morphological Mrimentioning

confidence: 99%

Pathogenesis, diagnosis and treatment of Rasmussen encephalitis: A European consensus statement

Bien

Granata

Antozzi

et al. 2005

Brain

524

740

View full text Add to dashboard Cite

show abstract

“…Although the patterns of metabolites observed are nonspecific. compared with normal hemisphere, the atrophic regions showed increased lactate, a consequence of repetitive focal epileptic neuronal activity 28,29 , as well as increased choline (related to gliosis, microglial proliferation and elevated membrane turnover 30 ) and reduced NAA. As NAA plays a role as neuron-glia signaling system 31 , this reduction reflects neuronal loss and axonal dysfunction/depletion 32 and possibly also changes in neurotransmitter system, altered in RE 33 .…”

Section: Discussionmentioning

confidence: 99%

MRI findings in the diagnosis and monitoring of rasmussen's encephalitis

Faria

Reis

Dabus

et al. 2009

Arq. Neuro-Psiquiatr.

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-Rasmussen's encephalitis is a devastating syndrome of multifocal brain dysfunction and focal seizures. Magnetic resonance (MR) findings, associated with clinical data and electroencephalogram (EEG), may indicate the diagnosis and could be an indicative of prognosis. We studied 5 patients with Rasmussen's encephalitis, assessing clinical history and MR images. All patients had refractory focal seizures with a predominant motor component associated with hemispheric atrophy, that was proportional to severity of disease and neurological deficits in these patients. Gray and white matter abnormal signal on T2 MR images were found in patients who had hemiparesis. It was not related to the duration of the disease but to aggressiveness. MR proton spectroscopy in severe disease showed lactate and choline increase and decreased NAA, reflecting neuronal and axonal loss, gliosis and elevated membrane turnover and recent -crisis (not controlled). MR studies, in addition to help in diagnosis, may be useful for monitoring metabolic changes and progression of disease in Rasmussen's encephalitis.KEy WoRds: Rasmussen's encephalitis, MRI, spectroscopy, epilepsy. Achados de RM no diagnóstico e monitorização da encefalite de RasmussenResumo -A encefalite de Rasmussen é uma devastadora síndrome com disfunção cerebral multifocal e convulsões focais. Achados de ressonância magnética (RM), associados aos dados clínicos e de eletrencefalograma (EEG), podem indicar o diagnóstico e podem ser indicativos de prognóstico. Foram estudados 5 pacientes com encefalite de Rasmussen, avaliando a história clínica e imagens de RM. Todos os pacientes apresentavam crises epilépticas focais refratárias com componente predominantemente motor associadas à atrofia hemisférica, que foi proporcional à gravidade da doença e déficits neurológicos nestes pacientes. Alteração da intensidade de sinal nas substâncias branca e cinzenta, nas sequências ponderadas em T2, foram encontradas nos pacientes com hemiparesia. Ela não estava relacionada com a duração da doença, mas à severidade. A espectroscopia de prótons por RM na doença severa demonstrou aumento dos níveis de colina e lactato e diminuição de N-acetilaspartato, refletindo perda neuronal e axonal, gliose e aumento de turnover de membrana e crise recente (não controlada). Estudos de RM, além de ajudar no diagnóstico, podem ser úteis para acompanhar alterações metabólicas e progressão da doença na encefalite de Rasmussen.PAlAvRAs-chAvE: encefalite de Rasmussen, RM, espectroscopia, epilepsia.

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“…MRI is of key importance when suspecting RE [9,[16][17][18] . First, it helps to exclude other conditions mimicking the disease, and on the other hand, it is needed to prove progression.…”

Section: Discussionmentioning

confidence: 99%

Rasmussen Encephalitis in the Sixth Decade: Magnetic Resonance Image Evolution and Immunoglobulin Response

et al. 2006

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MR-Monitored Remitting-Relapsing Pattern of Cortical Involvement in Rasmussen Syndrome: Comparative Evaluation of Serial MR and PET/SPECT Features

Cited by 11 publications

References 15 publications

Pathogenesis, diagnosis and treatment of Rasmussen encephalitis: A European consensus statement

Pathogenesis, diagnosis and treatment of Rasmussen encephalitis: A European consensus statement

MRI findings in the diagnosis and monitoring of rasmussen's encephalitis

Rasmussen Encephalitis in the Sixth Decade: Magnetic Resonance Image Evolution and Immunoglobulin Response

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