MR lymphography using iron oxide nanoparticles in rats: Pharmacokinetics in the lymphatic system after intravenous injection

Réty, F.; Clémеnt, Olivier; Siauve, Nathalie; Cuénod, Charles‐André; Carnot, Françoise; Sich, Mireille; Buisine, A.; Frija, G.

doi:10.1002/1522-2586(200011)12:5<734::aid-jmri10>3.0.co;2-r

Cited by 72 publications

(39 citation statements)

References 20 publications

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“…In addition, this study revealed isolated particles in the extracellular space of the lymph nodes soon after the injection, but their uptake by the macrophages was a slower process, in accordance with the slow uptake of ferumoxtran in liver cells (22) Although the data presented are only qualitative, they confirm the kinetic study of Réty et al (23) and suggest a rapid turnover and transcapillary passage of the particles not involving phagocytosis.…”

Section: Discussionsupporting

confidence: 85%

Distribution of iron oxide nanoparticles in rat lymph nodes studied using electron energy loss spectroscopy (EELS) and electron spectroscopic imaging (ESI)

Bréchot

Sich

Réty

et al. 2000

J. Magn. Reson. Imaging

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Section: Discussionsupporting

confidence: 85%

Distribution of iron oxide nanoparticles in rat lymph nodes studied using electron energy loss spectroscopy (EELS) and electron spectroscopic imaging (ESI)

Bréchot

Sich

Réty

et al. 2000

J. Magn. Reson. Imaging

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“…In particular, the largest number of SPION is nonspecifically accumulated in the liver by Kupffer cells after i.v. injection (20). For example, ferumoxide (Feridex) for MR imaging of the liver has been used as a reticuloendothelial system-specific contrast agent in clinical diagnosis (21).…”

Section: Discussionmentioning

confidence: 99%

Superparamagnetic iron oxide nanoparticles as a dual imaging probe for targeting hepatocytes in vivo

Lee

Jeong

Kim

et al. 2009

Magnetic Resonance in Med

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Hepatocyte-specific targeting agents are useful for evaluation of the hepatocytic function and the monitoring of disease progress. Superparamagnetic iron oxide nanoparticles (SPION) bearing terminal galactose groups exhibit a high affinity for the asialoglycoprotein receptor on the hepatocyte surface. In this study, we synthesized and characterized the dual probe SPION detectable by both nuclear and MR imaging modality for specifically targeting hepatocytes in vivo. SPION with 12-nm diameter were functionalized with dopamine. Surface modification of the SPION was performed to target asialoglycoprotein receptor on hepatocytes, using lactobionic acid. Transmission electron microscope images demonstrated that SPION displayed highly uniform characteristics in terms of both particle size and shape. The X-ray diffraction pattern of SPION revealed a nanocrystal structure of magnetite. To radiolabel the magnetite with 99m Tc, diethylenetriaminepentaacetic acid was conjugated to unreacted functional groups of dopamine. 99m Tc-labeled lactobionic acid-SPION showed high accumulation in liver, with 38.43 ؎ 6.45% injected dose per gram. In MR imaging, the reduction of the T 2 signal in the liver by lactobionic acid-SPION was approximately 50.8 ؎ 7.3%. Competition studies and transmission electron microscope images of liver tissues demonstrated that the lactobionic acid-SPION were localized in hepatocytes. Therefore, the lactobionic acid-SPION may be used as a hepatocyte-targeted dual contrast agent for both nuclear and MR imaging.

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“…Magnetic particles are gaining attraction due to a variety of technological applications such as high-density information storage nanodevices, ferrofluids, magnetic refrigeration, residential cooling, and biomedical applications like magnetic separations, biosensors, resonance imaging, hyperthermia, and targeted and controlled drug delivery. In this regard, spinel ferrites are particularly important because of their excellent magnetic properties that can be tuned to suit the requirement using chemical manipulations [7][8][9][10][11]. However, the development of novel techniques for improvements of the magnetic and the structural properties of soft magnetic spinel ferrites has been the objective of numerous studies in past decades.…”

Section: Introductionmentioning

confidence: 99%

Influence of Zn2+ doping on the structural and surface morphological properties of nanocrystalline Ni-Cu spinel ferrite

Awati¹,

Rathod

Mane

et al. 2013

Int Nano Lett

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Ni 0.8−x Cu 0.2 Zn x Fe 2 O 4 (x = 0.0 ≤ 0.6 with steps of 0.2) ferrite nanophase was achieved by sol-gel auto-combustion technique. The as-prepared samples were thermally characterized by thermogravimetry/differential thermal analysis to obtain firing temperature of the materials. The X-ray diffraction pattern indicates the formation of a single-phase cubic spinel structure and shows strong influence of the incorporation of Zn 2+ metal ions on the spinel structure. The annealing treatment does not alter the crystal structure but increases the crystallinity of the samples. The morphological investigations and nanometric sizes of the samples were studied by scanning electron microscopy and transmission electron microscopy. The crystallographic texture due to annealing and Zn 2+ ion doping was systematically investigated by Fourier transform infrared spectroscopy.

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MR lymphography using iron oxide nanoparticles in rats: Pharmacokinetics in the lymphatic system after intravenous injection

Cited by 72 publications

References 20 publications

Distribution of iron oxide nanoparticles in rat lymph nodes studied using electron energy loss spectroscopy (EELS) and electron spectroscopic imaging (ESI)

Distribution of iron oxide nanoparticles in rat lymph nodes studied using electron energy loss spectroscopy (EELS) and electron spectroscopic imaging (ESI)

Superparamagnetic iron oxide nanoparticles as a dual imaging probe for targeting hepatocytes in vivo

Influence of Zn2+ doping on the structural and surface morphological properties of nanocrystalline Ni-Cu spinel ferrite

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