MR Imaging of Therapeutic Magnetic Microcarriers Guided by Magnetic Resonance Navigation for Targeted Liver Chemoembolization

Abstract

MRI signal loss induced by TMMC can serve to track particle accumulation and to assess MRN efficiency.

High‐Resolution SPECT Imaging of Stimuli‐Responsive Soft Microrobots

“…Misra and co‐workers capitalized on ultrasound to follow the position of self‐propelled microparticles . Martel and co‐workers, and more recently, Zhang and co‐workers, have used magnetic resonance imaging (MRI) to track the position of magnetic microrobots in small animals. However to date, none of these reports have achieved single microrobot imaging with the ability to detect changes in microrobot configuration.…”

Toward Nonsystemic Delivery of Therapeutics Across the Blood–Brain Barrier

“…Biocompatible iron-oxide superparamagnetic nanoparticles used in MRN have already proved to be effective to orchestrate monitoring and steering in the MRI to deliver therapeutic agents through a suitable vascular route. Once at the target, various release mechanisms can be envisioned from the simple biodegradation of a polymer matrix [12] to the use of thermally triggered releases from hydrogel-based carriers [13].…”

“…While this technique has shown to be effective to target deep physiological regions such as the liver in animal models [12], it requires a proper BBB opening strategy to become clinically viable for nonsystemic target delivery to the brain. A recent published study [3] shows that the same superparamagnetic nanoparticles used to enable MRN could also temporary open the BBB.…”

A prototype of injector to control and to detect the release of magnetic beads within the constraints of multibifurcation magnetic resonance navigation procedures

“…Using an MR scanner has two major practical advantages: First, the B 0 field ensures a high magnetic force; and second, MRN is depth‐independent. Additionally, MRN efficiency and MDEB distribution within the organ can be assessed during the procedure, as the signal loss is correlated with MDEB concentration .…”