Peyronie's disease also known as penile fibromatosis and plastic induration of the penis is a cause of painful erection. It is rare with a prevalence rate of 0.4-9 %. It may be associated with Dupuytren's contracture. Though its etiopathogenesis is uncertain, presence of fibrin plaque and usual dorsal location is suggestive of aberrant healing response to minor penile trauma from shear stress. Ultrasound is useful in quantifying the fibrotic involvement in Peyronie's disease, determining the precise location of the lesion in the penis (dorsal / ventral / circumferential / septal), length, width and thickness of the plaque. It can detect fibrotic changes which have not yet calcified. We report two different cases of Peyronie's disease with calcification in intercorporeal septum alone and another case with calcified plaque in intercorporeal septum extending along the ventral aspect of both corpora cavernosa.