MR Imaging of Muscle Trauma: Anatomy, Biomechanics, Pathophysiology, and Imaging Appearance

Flores, Dyan V.; Gómez, Catalina Mejía; Estrada-Castrillón, Mauricio; Smitaman, Edward; Pathria, Mini N.

doi:10.1148/rg.2018170072

Cited by 96 publications

(67 citation statements)

References 81 publications

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“…While myosteatosis has been well documented in various types of muscle injuries and diseases, little is known about the ontogeny of fat accumulation in this condition (5,6). In the current study, we identified a progressive increase in TG after injury, with TG levels at 60 days that were 3-fold higher than controls.…”

Section: Discussionmentioning

confidence: 45%

“…Skeletal muscle often displays chronic degenerative changes following injury, including atrophy and weakness of muscle fibers, and fibrotic changes to the extracellular matrix (1)(2)(3)(4). Some muscles also display a pathological accumulation of lipid in response to chronic injury or disease, which is referred to as myosteatosis or fatty degeneration (5,6). The rotator cuff muscle group, which moves and stabilizes the shoulder joint, is particularly prone to develop myosteatosis after injury (7).…”

Section: Introductionmentioning

confidence: 99%

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Reduced mitochondrial lipid oxidation leads to fat accumulation in myosteatosis

Gumucio

Qasawa

Ferrara

et al. 2018

Preprint

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Myosteatosis is the pathological accumulation of lipid that can occur in conjunction with atrophy and fibrosis following skeletal muscle injury. Little is known about the mechanisms by which lipid accumulates in myosteatosis, but many clinical studies have demonstrated the degree of lipid infiltration negatively correlates with muscle function and regeneration. Our objective was to determine the pathological changes that result in lipid accumulation in injured muscle fibers. We used a rat model of rotator cuff injury in this study, as the rotator cuff muscle group is particularly prone to the development of myosteatosis after injury. Muscles were collected from uninjured controls, or 10, 30, or 60 days after injury, and analyzed using a combination of muscle fiber contractility assessments, RNA sequencing, and undirected metabolomics, lipidomics and proteomics, along with bioinformatics techniques, to identify potential pathways and cellular processes that are dysregulated after rotator cuff tear. Bioinformatics analyses indicated that mitochondrial function was likely disrupted after injury. Based on these findings, and given the role that mitochondria play in lipid metabolism, we then performed targeted biochemical and imaging studies and determined that mitochondrial dysfunction and reduced fatty acid oxidation likely leads to the accumulation of lipid in myosteatosis.

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Section: Discussionmentioning

confidence: 45%

Section: Introductionmentioning

confidence: 99%

Reduced mitochondrial lipid oxidation leads to fat accumulation in myosteatosis

Gumucio

Qasawa

Ferrara

et al. 2018

Preprint

View full text Add to dashboard Cite

show abstract

“…Although myosteatosis has been well documented in various types of muscle injuries and diseases, little is known about the ontogeny of fat accumulation in this condition (5,6). In the current study, we identified a progressive increase in TG after injury, with TG levels at 60 d that were 3-fold higher than controls.…”

Section: Discussionmentioning

confidence: 99%

“…Skeletal muscle often displays chronic degenerative changes following injury, including atrophy and weakness of muscle fibers and fibrotic changes to the extracellular matrix (ECM) (1)(2)(3)(4). Some muscles also display a pathologic accumulation of lipid in response to chronic injury or disease, which is referred to as myosteatosis or fatty degeneration (5,6). The rotator cuff muscle group, which is composed of the supraspinatus (SSP), infraspinatus, teres minor, and subscapularis, moves and stabilizes the shoulder joint and is particularly prone to developing myosteatosis after injury (7,8).…”

mentioning

confidence: 99%

Reduced mitochondrial lipid oxidation leads to fat accumulation in myosteatosis

et al. 2019

View full text Add to dashboard Cite

Myosteatosis is the pathologic accumulation of lipid that can occur in conjunction with atrophy and fibrosis following skeletal muscle injury. Little is known about the mechanisms by which lipid accumulates in myosteatosis, but many clinical studies have demonstrated that the degree of lipid infiltration negatively correlates with muscle function and regeneration. Our objective was to determine the pathologic changes that result in lipid accumulation in injured muscle fibers. We used a rat model of rotator cuff injury in this study because the rotator cuff muscle group is particularly prone to the development of myosteatosis after injury. Muscles were collected from uninjured controls or 10, 30, or 60 d after injury and analyzed using a combination of muscle fiber contractility assessments, RNA sequencing, and undirected metabolomics, lipidomics, and proteomics, along with bioinformatics techniques to identify potential pathways and cellular processes that are dysregulated after rotator cuff tear. Bioinformatics analyses indicated that mitochondrial function was likely disrupted after injury. Based on these findings and given the role that mitochondria play in lipid metabolism, we then performed targeted biochemical and imaging studies and determined that mitochondrial dysfunction and reduced fatty acid oxidation likely leads to the accumulation of lipid in myosteatosis.—Gumucio, J. P., Qasawa, A. H., Ferrara, P. J., Malik, A. N., Funai, K., McDonagh, B., Mendias, C. L. Reduced mitochondrial lipid oxidation leads to fat accumulation in myosteatosis. FASEB J. 33, 7863–7881 (2019). http://www.fasebj.org

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“…60 Hematomata should be followed up with ultrasound until resolution. Nodular peripheral enhancement in the absence of any history of significant trauma, anticoagulation, or defective coagulation should raise the suspicion of malignancy 62 (►Fig. 16c-e), and further evaluation with a biopsy and cross-sectional imaging is indicated following referral to a specialized sarcoma unit.…”

Section: Soft Tissue Tumorsmentioning

confidence: 99%

T2-weighted Hypointense Tumors and Tumor-like Lesions

Papakonstantinou

Isaac

Dalili

et al. 2019

Semin Musculoskelet Radiol

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Most musculoskeletal tumors are hyperintense on T2-weighted images. However, some T2-weighted hypointense tumors and tumor-like lesions are encountered in everyday clinical practice. We explore the spectrum of such T2 hypointense tumors and tumor mimickers that can arise from (1) the bones, presenting as diffuse processes or focal lesions; (2) the joints including diffuse or focal synovial disorders, loose bodies, or substance depositions; and (3) soft tissues, comprising T2 hypointense tumors and tumor mimickers (those that contain abundant fibrous tissue, mineralization, or hemosiderin deposits). Appropriate magnetic resonance imaging sequence selection is required to identify and characterize these lesions confidently when imaging musculoskeletal tumors.

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MR Imaging of Muscle Trauma: Anatomy, Biomechanics, Pathophysiology, and Imaging Appearance

Cited by 96 publications

References 81 publications

Reduced mitochondrial lipid oxidation leads to fat accumulation in myosteatosis

Reduced mitochondrial lipid oxidation leads to fat accumulation in myosteatosis

Reduced mitochondrial lipid oxidation leads to fat accumulation in myosteatosis

T2-weighted Hypointense Tumors and Tumor-like Lesions

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