MR Imaging of Hippocampal Asymmetry at 3T in a Multiethnic, Population-Based Sample: Results from the Dallas Heart Study

Lucarelli, Richard T.; Peshock, Ronald M; McColl, Roderick W; Hulsey, Keith; Ayers, Colby; Whittemore, Anthony R; King, Kevin S.

doi:10.3174/ajnr.a3308

Cited by 43 publications

(31 citation statements)

References 28 publications

(22 reference statements)

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“…In a meta-analysis, Pedraza and colleagues (2004) revealed larger right hippocampal volumes when compared with the left side in a sample of 82 studies. In a recent investigation, Lucarelli and colleagues (2013) also showed larger right hippocampal volumes in healthy adults. The authors detected a hemispheric asymmetry increase with age as well as gender effects with men showing greater asymmetry in hippocampus volumes (Lucarelli et al, 2013).…”

Section: Introductionmentioning

confidence: 82%

APOE associated hemispheric asymmetry of entorhinal cortical thickness in aging and Alzheimer's disease

Donix¹,

Burggren²,

Scharf³

et al. 2013

Psychiatry Research: Neuroimaging

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Across species structural and functional hemispheric asymmetry is a fundamental feature of the brain. Environmental and genetic factors determine this asymmetry during brain development and modulate its interaction with brain disorders. The e4 allele of the apolipoprotein E gene (APOE-4) is a risk factor for Alzheimer’s disease, associated with regionally specific effects on brain morphology and function during the life span. Furthermore, entorhinal and hippocampal hemispheric asymmetry could be modified by pathology during Alzheimer’s disease development. Using high-resolution magnetic resonance imaging and a cortical unfolding technique we investigated whether carrying the APOE-4 allele influences hemispheric asymmetry in the entorhinal cortex and the hippocampus among patients with Alzheimer’s disease as well as in middle-aged and older cognitively healthy individuals. APOE-4 carriers showed a thinner entorhinal cortex in the left hemisphere when compared with the right hemisphere across all participants. Non-carriers of the allele showed this asymmetry only in the patient group. Cortical thickness in the hippocampus did not vary between hemispheres among APOE-4 allele carriers and non-carriers. The APOE-4 allele modulates hemispheric asymmetry in entorhinal cortical thickness. Among Alzheimer’s disease patients, this asymmetry might be less dependent on the APOE genotype and a more general marker of incipient disease pathology.

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Section: Introductionmentioning

confidence: 82%

APOE associated hemispheric asymmetry of entorhinal cortical thickness in aging and Alzheimer's disease

Donix¹,

Burggren²,

Scharf³

et al. 2013

Psychiatry Research: Neuroimaging

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“…The neuroimaging acquisition and analysis methods of the DHS have been described in numerous other publications. (11, 23-26)…”

Section: Methodsmentioning

confidence: 99%

Hippocampal volume in patients with asthma: Results from the Dallas Heart Study

Carlson

Kim

Khan³

et al. 2016

Journal of Asthma

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Introduction Asthma is associated with an increased risk of mild cognitive impairment and dementia. Depression and oral corticosteroid use are associated with atrophy of the hippocampus and are common in asthma. However, minimal neuroimaging data are available in asthma patients. Methods We conducted a retrospective analysis of 1,287 adult participants from the Dallas Heart Study, an epidemiological sample of Dallas County residents. Study outcome variables were hippocampal volumes measured by FreeSurfer. ANOVA was used to examine a gender difference in hippocampal volumes. General Linear Models (GLM) were conducted to examine asthma diagnosis association with hippocampal volumes. Results The prevalence rate of asthma among our study sample was 10.8% with 9.6% in males and 11.7% in females. After controlling for demographic characteristics, participants with asthma had significantly smaller total, right, and left hippocampal volumes than those without asthma. The association of asthma with smaller hippocampal volume was significant among males but not among females. Conclusion Hippocampal volume in a large and diverse sample of adults was significantly smaller in people with asthma as compared to those without asthma. These findings suggest that asthma may be associated with structural brain differences. Thus, medical illnesses without obvious direct neurodegenerative or even vascular involvement can be associated with brain changes. Because the hippocampus is a brain region involved in memory formation, these findings may have implications for treatment adherence which could have important implications for asthma treatment. Study limitations are the reliance on a self-reported asthma diagnosis and lack of additional asthma clinical information.

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“…In addition, the study controlled for medication use, alcohol use, education, and other variables that might influence the relationship between depression and hippocampal volume. Another potential strength is the use of an automated method to derive hippocampal volumes that results in excellent reproducibility (Lucarelli et al, 2012;Nugent et al, 2012) and avoids a left-right bias that may be inherent with manual segmentation (Maltbie et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

“…DHS-2 was conducted from September 2007 to December 2009. For more information about DHS-2 please see these references (King et al, 2013;Kozlitina and Garcia, 2012;Lucarelli et al, 2013).…”

Section: Participants and Assessmentsmentioning

confidence: 99%

“…Thirty-seven were excluded for self-reported stroke. Images of outliers as found by Robust Minimum Covariance Distance analysis of brain segments (Lucarelli et al, 2013), individuals flagged for exclusion in previous DHS-2MR imaging brain studies, and individuals who had error flags generated during automated analysis were reviewed by a neuroradiologist (KSK). On MR imaging review, 70 individuals with major structural defects (such as corpus callosum agenesis, imaging evidence of stroke, and hydrocephalus) or image-acquisition errors (such as metal and motion artifacts, and other noise) were excluded.…”

Section: Neuroimagingmentioning

confidence: 99%

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Association of Depressive Symptoms with Hippocampal Volume in 1936 Adults

Brown

Hughes

McColl

et al. 2013

Neuropsychopharmacol

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Hippocampal atrophy is reported in major depressive disorder (MDD). However, sample sizes were generally modest, and participant characteristics, including age, differed between studies. This study used a community sample to examine relationships between current depressive symptom severity and hippocampal volume across the adult lifespan. A total of 1936 adults with magnetic resonance images of the brain and Quick Inventory of Depressive Symptomatology Self-Report (QIDS-SR) scores were included. Brain volumes were quantified using the FSL program. Multiple linear regressions were performed using left, right, and total hippocampal volume as criterion variables, and predictor variables of QIDS-SR total, total brain volume, age, gender, education, psychotropic medications, alcohol use, and race/ethnicity. Post hoc analyses were conducted in participants with QIDS-SR scores X11 (moderate or greater depressive symptom severity) and o11, and older and younger adults. In the primary analysis (sample as a whole) QIDS-SR was inversely associated with total hippocampal volume (b ¼ À 0.044, p ¼ 0.032, (CI À 0.019 to À 0.001)) but not with left or right hippocampal volume evaluated individually. In participants with QIDS-SR scores of o11, hippocampal volumes were not associated with QIDS-SR scores. In those with QIDS-SR scores X11 total, right, and left hippocampal volumes were modestly, but significantly, associated with QIDS-SR scores. The association between QIDS-SR scores and the hippocampal volume was much stronger in older persons. Findings suggest smaller hippocampal volumes among those with greater reported depressive symptom severity-an association that is strongest in people with at least moderate depressive symptom levels.

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MR Imaging of Hippocampal Asymmetry at 3T in a Multiethnic, Population-Based Sample: Results from the Dallas Heart Study

Cited by 43 publications

References 28 publications

APOE associated hemispheric asymmetry of entorhinal cortical thickness in aging and Alzheimer's disease

APOE associated hemispheric asymmetry of entorhinal cortical thickness in aging and Alzheimer's disease

Hippocampal volume in patients with asthma: Results from the Dallas Heart Study

Association of Depressive Symptoms with Hippocampal Volume in 1936 Adults

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