MR imaging of fetal brain abnormalities using a HASTE sequence

Tsuchiya, Kunihiko; Katase, Shichiro; Seki, Tomohiro; Mizutani, Yoshiyuki; Hachiya, Junichi

doi:10.1259/0007-1285-69-823-668

Cited by 35 publications

(19 citation statements)

References 8 publications

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“…To date, 15 studies encompassing 934 fetal MRI cases (including this review) have been reported using scanners at field strengths of 1.5 T or less, and no harmful effects to the developing fetus have been documented. This includes one large study of 400 fetuses, and another involving 20 children with a 3-year follow-up [1, 3, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37]. The second problem, motion artifact, has often been dealt with in the past by the administration of sedatives or paralytics, but the use of these agents obviously increases the complexity and risk of the study.…”

Section: Discussionmentioning

confidence: 99%

Fetal MRI in the Evaluation of Intrauterine Myelomeningocele

et al. 2000

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Background: Accurate fetal imaging is essential to the practice of maternal-fetal medicine. While ultrasonography has been the traditional mainstay of fetal imaging, its ability to resolve critical features of central nervous system (CNS) anatomy remains limited. As interest in intrauterine therapy for myelomeningocele has increased, so has the need for more accurate, noninvasive imaging of the CNS. Fetal magnetic resonance imaging (MRI) promises to fill the gap left by ultrasound. Methods: Thirty-seven MRI scans of fetuses previously diagnosed with myelomeningocele were reviewed by 2 neuroradiologists. The ability of fetal MRI to resolve the commonest CNS stigmata of spina bifida, and the incidence and extent of interobserver error, was assessed. In 4 cases, postnatal MRIs were also available. These were compared to the corresponding fetal studies. Results: The imaging quality with the technique used in this study was excellent, even without the use of maternal or fetal sedation. There were no complications, and the imaging times were minimal. Interobserver error was minimal with respect to the evaluation of ventricular dilatation and hindbrain herniation, but moderate in the description and location of the spinal lesion. As had previously been documented with ultrasonography, a reduction was seen in hindbrain herniation when comparing pre- and postnatal MRIs. Conclusion: It is concluded that fetal MRI is an effective, noninvasive means of assessing fetal CNS anatomy. Its ability to resolve posterior fossa anatomy is superior to ultrasonography while, with respect to the evaluation of hydrocephalus and the level and nature of the spinal lesion, it may be equivalent to inferior. Inclusion of the fetal MRI into the standard diagnostic armamentarium will probably await the next major advance in speed and resolution. It is conceivable that, with further advances, MRI might supplant ultrasonography as the diagnostic tool of choice for evaluation of fetal anomalies including myelomeningocele.

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Section: Discussionmentioning

confidence: 99%

Fetal MRI in the Evaluation of Intrauterine Myelomeningocele

et al. 2000

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“…Due to the excellent contrast afforded by T2-weighted images between the cerebrospinal fluid and the brain, HASTE imaging shows a great promise in evaluating the fetal brain abnormalities. Several similar cases using the HASTE sequence to diagnose fetal brain abnormalities have been reported recently [10,14,15].…”

Section: Discussionmentioning

confidence: 74%

“…Fetal curarization and/or maternal sedation before the examination is usually needed to eliminate motion artifacts [11][12][13]. However, the recently developed fast scanning techniques provide clear images in single-breath hold without premedication [10,14,15]. In the present report, we performed T1-weighted imaging with 2D-FLASH and T2-weighted imaging with HASTE.…”

Section: Discussionmentioning

confidence: 99%

Fetal Hydrocephalus Secondary to Intraventricular Hemorrhage Diagnosed by Ultrasonography and in utero Fast Magnetic Resonance Imaging

Hashimoto¹,

Tada²,

Nakatsuka³

et al. 1999

Fetal Diagn Ther

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Although fetal hydrocephalus is commonly detected by prenatal ultrasonographic examination, posthemorrhagic hydrocephalus has rarely been observed in the fetus. We report a case of hydrocephalus secondary to intraventricular hemorrhage (IVH) diagnosed by in utero magnetic resonance imaging (MRI) at 37 + 1 weeks of gestation. Ultrasonography revealed enlargement of the bilateral ventricles and an irregular mass measuring 20 × 12 × 10 mm in the right lateral ventricle. T1-weighted images with two-dimensional fast low-angle shot (2D-FLASH) and T2-weighted images with half-Fourier single-shot turbo spin echo (HASTE) demonstrated that an old hemorrhagic clot existed in the right lateral ventricle of the fetus. Hydrocephalus secondary to IVH was confirmed by postnatal MRI and ventriculoscopy. Fast MRI is especially useful for prenatal diagnosis of fetal brain abnormalities because it minimizes the artifact of fetal movement.

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“…2D slices from prenatal MRI have shown much less tissue contrast than that from postmortem studies [12,13]. However, these problems are being overcome with the availability of newer hardware and software allowing faster acquisition sequences such as echo-planar imaging and single-shot turbo spin echo (or HASTE) sequences [7,10] in the future. It is most likely that real-time MRI scanning will become clinically available and motion artefacts caused by fetal movement will therefore be minimized.…”

Section: Discussionmentioning

confidence: 99%

Three-Dimensional Imaging of the Postmortem Fetus by MRI: Early Experience

Brookes¹,

Deng

Wilkinson

et al. 1999

Fetal Diagn Ther

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Objective: The feasibility and significance of three-dimensional (3D) visualization of the postmortem fetus using magnetic resonance imaging (MRI) was investigated. Methods: 3D reconstruction of sectional MRI data sets from 8 postmortem fetuses was performed. Results: Fetal configurations and internal structures, both normal and pathological, were clearly demonstrated by 3D display. Conclusion: This new technique provides high quality fetal 3D images for postmortem morphological diagnosis and interactive visual teaching. It may eventually have applications in prenatal diagnosis and the preoperative simulation of fetal surgery.

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MR imaging of fetal brain abnormalities using a HASTE sequence

Cited by 35 publications

References 8 publications

Fetal MRI in the Evaluation of Intrauterine Myelomeningocele

Fetal MRI in the Evaluation of Intrauterine Myelomeningocele

Fetal Hydrocephalus Secondary to Intraventricular Hemorrhage Diagnosed by Ultrasonography and in utero Fast Magnetic Resonance Imaging

Three-Dimensional Imaging of the Postmortem Fetus by MRI: Early Experience

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