MR imaging of degenerative disc disease

Farshad‐Amacker, Nadja A.; Farshad, Mazda; Winklehner, Anna; Andreisek, Gustav

doi:10.1016/j.ejrad.2015.04.002

Cited by 63 publications

(39 citation statements)

References 53 publications

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“…Although MRI remains the gold standard for imaging of the degenerated disc, some radiological findings only occur in standing position, and MRI is usually performed in supine position [293], including in the papers that the present thesis in based upon. Tarantino et al [294] demonstrated that one third of patients with normal supine MRI had detectable IDD in upright MRI.…”

Section: Radiological Outcome Measuresmentioning

confidence: 99%

Total disc replacement versus multidisciplinary rehabilitation in patients with chronic low back pain and degenerative discs: 8-year follow-up of a randomized controlled multicenter trial

et al. 2017

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Section: Radiological Outcome Measuresmentioning

confidence: 99%

Total disc replacement versus multidisciplinary rehabilitation in patients with chronic low back pain and degenerative discs: 8-year follow-up of a randomized controlled multicenter trial

et al. 2017

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“…Compression of the nerve root by degenerated disc material, bone or ligaments can cause a radiculopathy. In the lumbar spine, the compression is commonly located within the spinal canal either median, paramedian or recessal causing radiculopathy of the descending nerve root [1][2][3][4]. However, radiculopathy can also be caused by compression of the exiting nerve root within the neural foramen, usually due to a disc herniation.…”

Section: Introductionmentioning

confidence: 99%

Severity of foraminal lumbar stenosis and the relation to clinical symptoms and response to periradicular infiltration—introduction of the “melting sign”

2018

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“…INTERVERTEBRAL DISC DEGENERATION (IVDD) is an age‐related disease with high morbidity worldwide. Although the pathogenesis of low back pain is not completely clear, IVDD is considered to be the most common cause . IVDD is characterized by the extent of dehydration of the disc nucleus pulposus (NP), followed by morphological changes including disc height reduction, bulging disc, herniation, and annulus fibrosus (AF) tear …”

mentioning

confidence: 99%

“…Anatomical magnetic resonance imaging (MRI) is being used routinely to depict morphological changes of intervertebral discs and assess the severity of degeneration . Previous studies have reported that quantitative water T 2 value correlates with disc hydration .…”

mentioning

confidence: 99%

Multiparametric MR Investigation of Proteoglycan Diffusivity, T₂ Relaxation, and Concentration in an Ex Vivo Model of Intervertebral Disc Degeneration

Wang

Tsang

Tam

et al. 2019

Magnetic Resonance Imaging

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Background: Proteoglycan (PG) is a major component of the intervertebral disc extracellular matrix (ECM) that acts to hydrate the disc nucleus. Early detection of PG degradation is valuable for both diagnosis and preclinical research of intervertebral disc degeneration (IVDD). Purpose: To compare different MR techniques for detecting early degradative changes of PG in IVDD. Study Type: Prospective. Phantom/Specimen: Glycosaminoglycan (GAG) phantom/bovine discs with papain injection and human cadaveric discs. Field Strength/Sequences: 7T/diffusion-weighted MR spectroscopy (DW-MRS), T 2 -weighted MRS (T 2 W-MRS), and chemical exchange saturation transfer (CEST) imaging. Assessment: DW-MRS, T 2 W-MRS, and CEST imaging were applied longitudinally to measure PG diffusivity, T 2 value, overall content, and spatial distribution in the disc nucleus with enzyme-induced proteolytic ECM degradation (n = 8). Similar MR measurements were applied in GAG phantom and human cadaveric discs with different levels of degeneration (n = 6). Statistical Tests: T-tests were conducted to measure the differences of PG properties between pre-and post-enzyme injection. Linear regression and mixed-effects models were used to assess the associations among different PG properties as well as the degeneration grades in human cadaveric discs. Results: In bovine discs, PG diffusivity increased most rapidly after the enzyme was injected into the disc nucleus (12 hours postinjection, t = 5.76, P = 0.0007). The PG T 2 value did not change significantly (t < 1.54, P > 0.17 for all timepoints) during ECM degradation and was not associated with PG diffusivity (t = 0.06, P = 0.95). PG distribution change was more rapid than overall PG content and was strongly associated with PG diffusivity increase (t = -9.25, P < 1 × 10 -8 ). In severely degenerated human cadaveric discs, the PG ADCs and T 2 values were both associated with degeneration grades. Data Conclusion: PG diffusivity is a direct biomarker for early ECM degradation, while PG distribution can be an indirect biomarker for early IVDD. Level of Evidence: 2 Technical Efficacy Stage: 2

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MR imaging of degenerative disc disease

Cited by 63 publications

References 53 publications

Total disc replacement versus multidisciplinary rehabilitation in patients with chronic low back pain and degenerative discs: 8-year follow-up of a randomized controlled multicenter trial

Total disc replacement versus multidisciplinary rehabilitation in patients with chronic low back pain and degenerative discs: 8-year follow-up of a randomized controlled multicenter trial

Severity of foraminal lumbar stenosis and the relation to clinical symptoms and response to periradicular infiltration—introduction of the “melting sign”

Multiparametric MR Investigation of Proteoglycan Diffusivity, T₂ Relaxation, and Concentration in an Ex Vivo Model of Intervertebral Disc Degeneration

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MR imaging of degenerative disc disease

Cited by 63 publications

References 53 publications

Total disc replacement versus multidisciplinary rehabilitation in patients with chronic low back pain and degenerative discs: 8-year follow-up of a randomized controlled multicenter trial

Total disc replacement versus multidisciplinary rehabilitation in patients with chronic low back pain and degenerative discs: 8-year follow-up of a randomized controlled multicenter trial

Severity of foraminal lumbar stenosis and the relation to clinical symptoms and response to periradicular infiltration—introduction of the “melting sign”

Multiparametric MR Investigation of Proteoglycan Diffusivity, T2 Relaxation, and Concentration in an Ex Vivo Model of Intervertebral Disc Degeneration

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Multiparametric MR Investigation of Proteoglycan Diffusivity, T₂ Relaxation, and Concentration in an Ex Vivo Model of Intervertebral Disc Degeneration