1986
DOI: 10.1097/00004728-198611000-00032
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MR Imaging of a Hepatoma Associated with Alagille Syndrome

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1989
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Cited by 20 publications
(8 citation statements)
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“…Since the syndrome was first described in 1987, less than 20 cases of HCC have been reported in the world literature and only seven cases in adults [10][11][12][13][14][15][16][17][18]. Table 1 summarizes all reported cases of HCC in the English language.…”
Section: Discussionmentioning
confidence: 99%
“…Since the syndrome was first described in 1987, less than 20 cases of HCC have been reported in the world literature and only seven cases in adults [10][11][12][13][14][15][16][17][18]. Table 1 summarizes all reported cases of HCC in the English language.…”
Section: Discussionmentioning
confidence: 99%
“…Previous reports of the various skeletal abnormalities of patients with this syndrome were summarized by Rosen field et al in 1980 and by Brunelle et al in 1986 [3, 12]. Of interest are three separate case reports of hepatocellular carcinoma in association with Alagille's syndrome [13][14][15]. In all three cases, CT scan of the liver was performed; two had MRI scans, two had sonograms, and one had a Tc99m DISIDA scan.…”
Section: Discussionmentioning
confidence: 99%
“…Therefore, it seems plausible to suggest that the gene(s) for Alagille syndrome is located on the short arm of chromosome 20. Moreover, the occurrence of hepatocellular carcinoma in children with Alagille syndrome [Kaufman et al, 1987;Ong et al, 1986;Rabinovitz et al, 19891 and in an adult Alagille syndrome patient without cirrhosis [Adams, 19861 has been previously explained by chronic liver disease, but in the light of the present observation one can speculate that loss of heterozygosity for a cell-cycleregulating gene may be an alternative explanation, as is observed in retinoblastoma [Hansen and Cavence, 19881.…”
Section: Discussionmentioning
confidence: 70%