MR imaging evaluation with a transrectal surface coil of local recurrence of prostatic cancer in men who have undergone radical prostatectomy.

Silverman, J. M.; Krebs, Thorsten

doi:10.2214/ajr.168.2.9016212

Cited by 136 publications

(47 citation statements)

References 12 publications

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“…The authors were not able to detect local recurrence in patients with PSA values below 0.45 ng/ml with 1.5-T MRI. in vivo 32: 125-131 (2018) These results concur with those provided by Silverman and coworkers, who reported the range where recurrent disease was suspected to be 0.4-11 ng/ml (38). Three studies reported that detection of local failure may be possible in patients with a PSA level below 0.4 ng/ml but one study was performed under systemic treatment for prostate cancer (37), therefore the results do not apply to the typical situation in which salvage radiation therapy is initiated.…”

Section: Discussionsupporting

confidence: 84%

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Detection of Local Recurrence with 3-Tesla MRI After Radical Prostatectomy: A Useful Method for Radiation Treatment Planning?

Buergy

Sertdemir²,

Weidner

et al. 2018

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Abstract. Background Prostate carcinoma is the second most common cancer in males (1) and although mortality rates have decreased in European countries and the United States (US), it still accounts for more than 258,000 deaths worldwide (2). According to the USpopulation-based Surveillance, Epidemiology, and End Results Program database, ~80% of men with newly diagnosed prostate carcinoma had localized disease at the time of diagnosis (3). Most of these patients selected radical prostatectomy or external beam radiotherapy as their primary treatment option (4,5). Recurrence rates after radical prostatectomy differ widely between around 10% of patients and more than 30% within 5 years (6-8), depending on Gleason score and other risk factors (6). In patients with positive surgical margins, it can be estimated that 20-40% of tumors recur (9, 10) and the majority of patients with biochemical relapse are diagnosed as having local recurrence (11). Radiotherapy as salvage treatment has been shown to improve biochemical control in patients with residual disease or biochemical relapse (12, 13). Stephenson et al. estimated that biochemical control can be achieved by radiotherapy in 48% of patients when salvage treatment starts before the prostatespecific antigen (PSA) level reaches 0.5 ng/ml; if administered at a PSA level of 0.5 ng/ml and above, only 26% of patients treated were free from (further) relapse (14). These results have been confirmed by modern series which additionally showed a clinical benefit in terms of distant metastasis-free survival, disease-specific mortality, and all-cause mortality (15). Furthermore, modern series indicated early salvage radiotherapy, initiated at the earliest sign of measurable PSA, to be beneficial in terms of biochemical and clinical endpoints (15, 16). Severe toxicity of salvage radiotherapy is generally reported to be low (17) but even in modern series, there is a residual risk of grade 3/4 bowel or urinary toxicity (18). 125This article is freely accessible online. (28,29). In a comparative study (29), radiotherapy plans contoured according to consensus guidelines failed to meet QUANTEC (30), and RADICALS (31) trial dose constraints in 75%, and 40% of cases, respectively. These inconsistencies indicate that our current approaches to salvage treatment of prostate carcinoma after radical prostatectomy should be reassessed. Improvement of therapeutic efficacy could be achieved by reducing geographical miss and side-effects by accurate detection of residual disease.Detection of residual prostate carcinoma is possible by magnetic resonance imaging (MRI) and positron-emission tomography-computed tomography (PET-CT). Evidence on restaging of biochemically relapsed patients with PET-CT was recently reviewed by Umbehr et al. (32). The authors analyzed 12 studies and found a pooled sensitivity and specificity of 85%, and 88%, respectively (mean PSA=7.9 ng/ml). In patients with early relapse (PSA <1 ng/ml), however, the authors found no convincing evidence for the use of PET-CT.MRI with (...

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Section: Discussionsupporting

confidence: 84%

“…Most studies have been performed on 1.5-T MR systems (33)(34)(35)(36) and local recurrence was in some cases detected in patients with PSA levels of 1-2 ng/ml or less (35)(36)(37)(38). Despite these results, it remains controversial, if local recurrence may be detected by 1.5-T MRI before PSA levels rise above 1 ng/ml (20).…”

mentioning

confidence: 99%

Detection of Local Recurrence with 3-Tesla MRI After Radical Prostatectomy: A Useful Method for Radiation Treatment Planning?

Buergy

Sertdemir²,

Weidner

et al. 2018

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“…5 Early detection of local recurrence is important because these recurrences can be treated by external radiation with good response. A focus of soft tissue in the prostate surgical bed demonstrating slightly high T 2 signal compared with the pelvic muscles with contrast wash-in and wash-out at DCE MRI is suggestive of local recurrence (Figure 1).…”

Section: Following Radical Prostatectomymentioning

confidence: 99%

Diagnosis of recurrent prostate cancer and its mimics at multiparametric prostate MRI

Notley

Fulcher

et al. 2015

BJR

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Biochemical recurrence after treatment for prostate cancer (PCa) is a significant issue. Early diagnosis of local recurrence is important for making prompt treatment decisions and is strongly associated with patient prognosis. Without salvage therapy, the average time from development of local recurrence to distant metastasis is approximately 3 years. Biochemical recurrence does not differentiate local recurrence from systemic disease; there is no reliable way to clinically diagnose local recurrence. Recent advances in multiparametric MRI (mp-MRI) techniques have markedly improved detection of local recurrence following therapy. However, a wide variety of entities can mimic recurrent PCa at mp-MRI. Therefore, the purpose of this pictorial review is to discuss the MRI findings of locally recurrent PCa and its mimics, emphasizing the key MRI features that help to differentiate local recurrence from its mimics.

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“…Currently, clinical nomograms are used to predict the risk of biochemical recurrence; however, these nomograms have some limitations related to their variables, such as the low specificity of serum PSA and underestimated Gleason score at biopsy. MRI has been shown to improve the detection of local recurrence in patients with RP in a few studies (59)(60). Although it is challenging to detect local recurrence on T2W MR images, the combined use of T2W MRI with DCE-MRI results in a higher yield in detecting local recurrence (61) (Fig.…”

Section: Mri As a Monitoring Tool For Treatment Follow-upmentioning

confidence: 99%

Magnetic resonance imaging of localized prostate cancer: coming of age in the psa era

Türkbey

Bernardo²,

Merino³

et al. 2011

Diagn Interv Radiol

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Prostate cancer is the most common cancer among American men. It varies widely in aggressiveness, ranging from completely indolent to highly aggressive. Currently, predicting the natural history of a particular tumor and deciding on the appropriate treatment, which might include active surveil-lance, surgery, radiation or hormonal therapies, are based on the condition and age of the patient as well as the presumed stage of the disease. Imaging plays an important role in staging localized prostate cancer. Magnetic resonance imaging (MRI) best depicts the zonal anatomy, with a superior soft tissue resolution providing better results for tumor localization, monitoring, and local staging. Previously, the major function of prostate MRI has been in staging, and this role remains important. In this article, we introduce the reader to the expanding roles that MRI plays in the management of localized prostate cancer.

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MR imaging evaluation with a transrectal surface coil of local recurrence of prostatic cancer in men who have undergone radical prostatectomy.

Cited by 136 publications

References 12 publications

Detection of Local Recurrence with 3-Tesla MRI After Radical Prostatectomy: A Useful Method for Radiation Treatment Planning?

Detection of Local Recurrence with 3-Tesla MRI After Radical Prostatectomy: A Useful Method for Radiation Treatment Planning?

Diagnosis of recurrent prostate cancer and its mimics at multiparametric prostate MRI

Magnetic resonance imaging of localized prostate cancer: coming of age in the psa era

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