MR Imaging–controlled Transurethral Ultrasound Therapy for Conformal Treatment of Prostate Tissue: Initial Feasibility in Humans

Abstract

MR imaging-controlled transurethral ultrasound therapy is feasible, safe, and well tolerated. This technology could be an attractive approach for whole-gland or focal therapy.

Magnetic Resonance Image Guided Transurethral Ultrasound Prostate Ablation: A Preclinical Safety and Feasibility Study with 28-Day Followup

“…6 Although the study confirmed preclinical findings, the timing of radical prostatectomy prevented interpretation of treatment related adverse events.…”

“…1 ½F1 ). 6 A transurethral device delivers high intensity ultrasound directly into the prostate, quickly raising temperatures to the point of thermal coagulation. 7e10 MRI thermometry measurements acquired in real time during treatment are applied by a control algorithm to adjust the ultrasound output (power, frequency and rotation rate) and conform ablation volume the specific prostate geometry of the patient.…”

Real-Time MRI-Guided Focused Ultrasound for Focal Therapy of Locally Confined Low-Risk Prostate Cancer: Feasibility and Preliminary Outcomes

“…Proof-of-principle studies have shown that real-time MRI-guided focused ultrasound can produce extensive coagulative necrosis with no residual tumor, excellent concordance with target zones, and postablation dynamic contrast-enhanced MRI [16,25]. Ahmed and colleagues [26] treated 41 patients with focused ultrasound planned with pretreatment MRI and TRUS mapping biopsy delivered without real-time MRI monitoring.…”

In-bore MRI interventions

“…The procedure is performed under spinal or general anesthesia after insertion of a suprapubic catheter for continuous drainage of the urinary bladder. Chopra et al [59] reported the first proof-of-principle study demonstrating its safety and feasibility in eight patients for localized PCa. The treatment volume in this study was a 1808 sector of the posterior gland.…”