MR imaging and MIBG scintigraphy of pheochromocytomas and extraadrenal functioning paragangliomas.

Gils, A P van; Falke, T. H. M.; Erkel, Arian R. van; Arndt, J. W.; Sandler, Martin P.; Mey, A G van der; Hoogma, Roel P.L.M.

doi:10.1148/radiographics.11.1.1671719

Cited by 122 publications

(56 citation statements)

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“…MIBG scintigraphy may also be helpful to rule out clinically silent cases, but the specificity for diagnosis of nonfunctional paraganglioma is unclear [13] . In certain cases, FDG-PET may be indicated to investigate metastatic disease [7] .…”

Section: Discussionmentioning

confidence: 99%

Mesenteric paraganglioma: Report of a case

Fujita¹,

Kamiya²,

Takahashi³

et al. 2013

WJGS

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We report a rare case of paraganglioma that developed in the mesentery of terminal ileum. A 78-yearold woman complained of right-sided abdominal pain. Abdominal computed tomography revealed a solid heterogeneously enhanced mass in the right lower abdomen. The tumor was laparoscopically excised. The mesenteric tumor was well circumscribed, ovoid, and encapsulated and measured 3 cm × 1.5 cm × 1.5 cm. Histological examination showed a cellular neoplasm comprised of nests and groups of tumor cells separated by fibrovascular connective tissue, giving a characteristic nested Zellballen pattern. Immunohistochemically, the tumor cells were positive for chromogranin, synaptophysin, CD56, and vimentin and negative for cytokeratins, SMA, CD34, CD117/c-kit and S100. On the basis of histologic and immunohistochemical features, a diagnosis of mesenteric paraganglioma was made. The operative and postoperative courses were unremarkable, and the patient was discharged on postoperative day 7. She was doing well 1 year after the surgery with no signs of recurrence. Extra-adrenal paragangliomas most commonly develop adjacent to the aorta, particularly the area corresponding to the organ of Zuckerkandl. Mesenteric paraganglioma, as in our case, is extremely rare; only 11 cases have been reported in the literature. We herein discuss the clinical findings of these cases.

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Section: Discussionmentioning

confidence: 99%

Mesenteric paraganglioma: Report of a case

Fujita¹,

Kamiya²,

Takahashi³

et al. 2013

WJGS

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“…In the living patients, multiplicity (50%) and hormonal activity (21%) was diagnosed in a considerably higher frequency than has been reported in the past (Grufferman et 13 1935 1920 1922 1923 1927 1928 1930 1928 1929 1933 1936 1943 1946 1948 (van Gils et al, 1991). Moreover, MRI can detect chemodectomas smaller than 5 mm, while contrast enhanced CT only allows detection of tumours greater than 8 mm (Vogl et al, 1989 (Grimley, 1989 (van Gils et al, 1990).…”

Section: Glomus Tumoursmentioning

confidence: 95%

MRI screening of kindred at risk of developing paragangliomas: support for genomic imprinting in hereditary glomus tumours

Gils¹,

Mey²,

Hoogma³

et al. 1992

Br J Cancer

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“…Ten percent of phaeochromocytomas originate in extra-adrenal localisations and can be detected with 123 I-MIBG scintigraphy [1]. We report on a 50-year-old patient with weight loss, night sweating and increased urinary noradrenaline levels.…”

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confidence: 88%

MIBG-SPECT/CT-angiography with 3-D reconstruction of an extra-adrenal phaeochromocytoma with dissection of an aortic aneurysm

Strobel

Burger

Schneider

et al. 2006

Eur J Nucl Med Mol Imaging

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Phaeochromocytomas can cause severe complications like stroke, lung oedema, myocardial infarction or aortic dissection. Ten percent of phaeochromocytomas originate in extra-adrenal localisations and can be detected with 123 I-MIBG scintigraphy [1]. We report on a 50-year-old patient with weight loss, night sweating and increased urinary noradrenaline levels. SPECT with 358 MBq 123 I-MIBG and additionally a dual-phase diagnostic CT were performed, showing increased MIBG uptake para-aortally on the left side (a,b, arrow) corresponding to a hypervascularised lesion visible on CT (b, arrow) [2]. Additionally, in CT a thoracic aneurysm with type B aortic dissection (a,b, arrowheads) was detected. For surgical planning, CT-angiography and SPECT were combined in a fused 3D rendering using the PMOD 2.75 software (see figure). The paraganglioma was resected and 1 month later the aneurysm was successfully treated with a stent graft. There are some case reports in the literature about phaeochromocytomas associated with aortic or carotid dissections [3][4][5]. SPECT/CT-angiography with fused 3D reconstruction requires appropriate software and some postprocessing time but provides the surgeon with important functional and morphological information for adequate therapy planning.

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MR imaging and MIBG scintigraphy of pheochromocytomas and extraadrenal functioning paragangliomas.

Cited by 122 publications

References 0 publications

Mesenteric paraganglioma: Report of a case

Mesenteric paraganglioma: Report of a case

MRI screening of kindred at risk of developing paragangliomas: support for genomic imprinting in hereditary glomus tumours

MIBG-SPECT/CT-angiography with 3-D reconstruction of an extra-adrenal phaeochromocytoma with dissection of an aortic aneurysm

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