MR-Guided Cryotherapy

Tacke, J.; Speetzen, R.

doi:10.1007/978-3-642-60272-6_24

Cited by 4 publications

(2 citation statements)

References 30 publications

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“…Frozen tissue exhibits a signal void in MR images due to its extremely short T2 relaxation time. 31 Several reports exist on cryotherapy with open-type low-or middle-ˆeld MRI guidance. [32][33][34][35][36][37][38]…”

Section: Interventional Mrimentioning

confidence: 99%

Utilization of Low-Field MR Scanners

et al. 2004

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The evident advantage of high-field MR (magnetic resonance) scanners is their higher signal-to-noise ratio, which results in improved imaging. While no reliable efficacy studies exist that compare the diagnostic capabilities of low- versus high-field scanners, the adoption and acceptance of low-field MRI (magnetic resonance imaging) is subject to biases. On the other hand, the cost savings associated with low-field MRI hardware are obvious. The running costs of a non-superconductive low-field scanner show even greater differences in favor of low-field scanners. Patient anxiety and safety issues also reflect the advantages of low-field scanners. Recent technological developments in the realm of low-field MR scanners will lead to higher image quality, shorter scan times, and refined imaging protocols. Interventional and intraoperative use also supports the installation of low-field MR scanners. Utilization of low-field systems has the potential to enhance overall cost reductions with little or no loss of diagnostic performance.

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Section: Interventional Mrimentioning

confidence: 99%

Utilization of Low-Field MR Scanners

et al. 2004

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“…Methods of tissue destruction include phototherapy, 2 radiofrequency lesioning, 7,40 cryoablation, 53 microwave ablation, 41,52 high-intensity focused ultrasonography, 19,32,55 and laser interstitial thermotherapy. 3,31,49 Mechanisms of tissue destruction include changes in local temperature resulting in coagulation necrosis 18,50 (radiofrequency lesioning, laser interstitial thermotherapy, and high-intensity focused ultrasonography) and cell membrane rupture 18 (cryoablation), generation of free-radicals (phototherapy), and in situ tissue fixation (microwaves).…”

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confidence: 99%

Nonthermal irreversible electroporation for intracranial surgical applications

Ellis

García

Rossmeisl

et al. 2011

JNS

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Object. Nonthermal irreversible electroporation (NTIRE) is a novel, minimally invasive technique to treat cancer, which is unique because of its nonthermal mechanism of tumor ablation. This paper evaluates the safety of an NTIRE procedure to lesion normal canine brain tissue.Methods. The NTIRE procedure involved placing electrodes into a targeted area of brain in 3 dogs and delivering a series of short and intense electric pulses. The voltages of the pulses applied were varied between dogs. Another dog was used as a sham control. One additional dog was treated at an extreme voltage to determine the upper safety limits of the procedure. Ultrasonography was used at the time of the procedure to determine if the lesions could be visualized intraoperatively. The volumes of ablated tissue were then estimated on postprocedure MR imaging. Histological brain sections were then analyzed to evaluate the lesions produced.Results. The animals tolerated the procedure with no apparent complications except for the animal that was treated at the upper voltage limit. The lesion volume appeared to decrease with decreasing voltage of applied pulses. Histological examination revealed cell death within the treated volume with a submillimeter transition zone between necrotic and normal brain.Conclusions. The authors' results reveal that NTIRE at selected voltages can be safely administered in normal canine brain and that the volume of ablated tissue correlates with the voltage of the applied pulses. This preliminary study is the first step toward using NTIRE as a brain cancer treatment.

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MRI/CAT Scanners

Abramovits

2016

Dermatological Cryosurgery and Cryotherapy

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MR-Guided Cryotherapy

Cited by 4 publications

References 30 publications

Utilization of Low-Field MR Scanners

Utilization of Low-Field MR Scanners

Nonthermal irreversible electroporation for intracranial surgical applications

MRI/CAT Scanners

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