MR Elastography of the Prostate: Initial In-vivo Application

Kemper, J.; Sinkus, Ralph; Lorenzen, J.; Nolte-Ernsting, C.; Stork, Alexander; Adam, Gerhard

doi:10.1055/s-2004-813279

Cited by 106 publications

(110 citation statements)

References 14 publications

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“…MRE measurements indicated that the peripheral portion of the prostate was stiffer than the central portion. The mean Young's modulus values were 9.9 kPa and 6.6 kPa, respectively (Kemper et al 2004). Significant discrepancies were also found on the reported stiffness of kidney tissue (Erkamp et al 1998;Kruse et al 2000;Nasseri et al 2002;Snedeker et al 2005).…”

Section: Introductionmentioning

confidence: 99%

“…The potential of dynamic MRE clinical implementation has been proven in preliminary human studies in which the data of human prostate, breast, brain, muscle, and liver were presented (Bensamoun et al 2006;Bishop et al 1998;Kemper et al 2004;Kruse et al 2000;Papazoglou et al 2006;Rouviere et al 2006;Sinkus et al 2005). In particular, Kruse et al (2000) evaluated porcine livers with MRE at multiple shear wave frequencies and reported that the wave velocity and the shear stiffness increased with frequency.…”

Section: Introductionmentioning

confidence: 99%

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Congruence of Imaging Estimators and Mechanical Measurements of Viscoelastic Properties of Soft Tissues

Zhang

Castaneda

et al. 2007

Ultrasound in Medicine & Biology

101

112

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Biomechanical properties of soft tissues are important for a wide range of medical applications, such as surgical simulation and planning and detection of lesions by elasticity imaging modalities. Currently, the data in the literature is limited and conflicting. Furthermore, to assess the biomechanical properties of living tissue in vivo, reliable imaging-based estimators must be developed and verified. For these reasons we developed and compared two independent quantitative methods -crawling wave estimator (CRE) and mechanical measurement (MM) for soft tissue characterization. The CRE method images shear wave interference patterns from which the shear wave velocity can be determined and hence the Young's modulus can be obtained. The MM method provides the complex Young's modulus of the soft tissue from which both elastic and viscous behavior can be extracted. This article presents the systematic comparison between these two techniques on the measurement of gelatin phantom, veal liver, thermal-treated veal liver, and human prostate. It was observed that the Young's moduli of liver and prostate tissues slightly increase with frequency. The experimental results of the two methods are highly congruent, suggesting CRE and MM methods can be reliably used to investigate viscoelastic properties of other soft tissues, with CRE having the advantages of operating in nearly real time and in situ.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Congruence of Imaging Estimators and Mechanical Measurements of Viscoelastic Properties of Soft Tissues

Zhang

Castaneda

et al. 2007

Ultrasound in Medicine & Biology

101

112

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show abstract

“…Previously MRE has been successfully applied to the study of the mechanical properties of a variety of other organs and soft tissue regions in vivo, including the breast, brain, kidney, prostate, liver, and muscle. [16][17][18][19][20] Application to the lungs has proven more challenging given the poor signal-to-noise available in imaging due to a lower presence of hydrogen in air than in soft tissue (containing water) and the complex nature of vibratory wave propagation found in the lungs. A better understanding of mechanical wave motion in the lungs would aid in the interpretation of the wave images that are acquired using MRE to reconstruct a quantitative map of variation in mechanical properties that can correlate with injury, the progression of disease, and/or the response to therapy.…”

Section: Introduction a Motivationmentioning

confidence: 99%

A comprehensive computational model of sound transmission through the porcine lung

Dai

Peng

Henry

et al. 2014

The Journal of the Acoustical Society of America

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A comprehensive computational simulation model of sound transmission through the porcine lung is introduced and experimentally evaluated. This "subject-specific" model utilizes parenchymal and major airway geometry derived from x-ray CT images. The lung parenchyma is modeled as a poroviscoelastic material using Biot theory. A finite element (FE) mesh of the lung that includes airway detail is created and used in COMSOL FE software to simulate the vibroacoustic response of the lung to sound input at the trachea. The FE simulation model is validated by comparing simulation results to experimental measurements using scanning laser Doppler vibrometry on the surface of an excised, preserved lung. The FE model can also be used to calculate and visualize vibroacoustic pressure and motion inside the lung and its airways caused by the acoustic input. The effect of diffuse lung fibrosis and of a local tumor on the lung acoustic response is simulated and visualized using the FE model. In the future, this type of visualization can be compared and matched with experimentally obtained elastographic images to better quantify regional lung material properties to noninvasively diagnose and stage disease and response to treatment.

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“…Elastography has opened new possibilities to determine elasticity. Recently, Kemper et al [9] published elasticity coefficients for the prostate. We have also performed another parallel study concerning the ability to translate FEM parameters (Young modulus for instance) in a local shape memory force.…”

Section: Discussionmentioning

confidence: 99%

Simulating Complex Organ Interactions: Evaluation of a Soft Tissue Discrete Model

Marchal¹,

Promayon²,

Troccaz³

2005

Advances in Visual Computing

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Abstract.Computer assisted procedures play a key role in the improvement of surgical operations. The current techniques in simulation potentially lead to more accuracy, more safety and more predictability in the surgical room. Despite the important number of algorithms proposed for interactively modelling deformable objects such as soft human tissues, very few methods have attempted to simulate complex anatomical configurations. In this paper, we present a new approach for soft tissue modelling whose novelty is to integrate the interactions between a given soft organ and its surrounding organs. The proposed discrete model is compared to finite element method in order to quantify its performance and physical realism. The model is applied to the simulation of the prostate-bladder set.

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MR Elastography of the Prostate: Initial In-vivo Application

Abstract: In-vivo MRE of the prostate gland is technically feasible. The proposed experimental set-up allows the efficient insertion of the mechanical wave into the prostate gland and provides a successful MR data acquisition.

Cited by 106 publications

References 14 publications

Congruence of Imaging Estimators and Mechanical Measurements of Viscoelastic Properties of Soft Tissues

Congruence of Imaging Estimators and Mechanical Measurements of Viscoelastic Properties of Soft Tissues

A comprehensive computational model of sound transmission through the porcine lung

Simulating Complex Organ Interactions: Evaluation of a Soft Tissue Discrete Model

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