MR elastography of breast lesions: Understanding the solid/liquid duality can improve the specificity of contrast‐enhanced MR mammography

Sinkus, Ralph; Siegmann, K. C.; Xydeas, T.; Tanter, Mickaël; Claussen, Claus D.; Fink, Mathias

doi:10.1002/mrm.21404

Cited by 284 publications

(303 citation statements)

References 42 publications

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“…The viscoelastic mechanical shear properties (dynamic shear modulus G d and loss modulus G l ) were determined using the curl-based direct inversion of the 3D wave equation assuming an isotropic linear material, that is incompressible and homogeneous (15,16). In this method, the compressional component of the wave equation is removed by applying the curl operator, resulting in a 3D shear wave equation with the complex shear modulus G as the only unknown once the tissue density is assumed.…”

Section: Image Processingmentioning

confidence: 99%

MR elastography and diffusion‐weighted imaging of ex vivo prostate cancer: quantitative comparison to histopathology

et al. 2014

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Purpose-1) to develop a Magnetic Resonance Elastography (MRE) system for imaging of the ex-vivo human prostate, 2) to assess the diagnostic power of mono-frequency and multi-frequency MRE and diffusion weighted imaging (DWI) alone and combined as correlated with histopathology in a patient study.Materials and Methods-An electromagnetic driver was designed specifically for MRE studies in small-bore MR scanners. Ex-vivo prostate specimens (post-fixation) of fourteen patients who underwent radical prostatectomy were imaged with MRE at 7 T (nine cases had DWI). In six patients, the MRE examination was performed at three frequencies (600, 800, 1000 Hz) to extract the power-law exponent Gamma. The images were registered to wholemount pathology slides marked with the Gleason score. The areas under the Receiver-Operator-Characteristic curves (AUC) were calculated.Results-The methods were validated in a phantom study and demonstrated that (i) the driver does not interfere with the acquisition process, (ii) the driver can generate amplitudes greater than 100 μm for frequencies <1kHz. In the quantitative study, cancerous tissue with Gleason score at least 3+3 was distinguished from normal tissue in the peripheral zone with an average AUC of 0.75 (G d ), 0.75 (G l ), 0.70 (Gamma-G d ), 0.68 (ADC), and 0.82 (G d +G l +ADC). The differentiation between PZ and CG was modest for G d (p<0.07), G l (p<0.06) but not significant for Gamma (p<0.2). A correlation of 0.4 kPa/h was found between fixation time of the prostate specimen to the stiffness of the tissue which could affect the diagnostic power results.Conclusion-DWI and MRE may provide complementary information; in fact MRE performed better than ADC in distinguishing normal from cancerous tissue in some cases. Multi-frequency (Gamma) analysis did not appear to improve the results. However, in light of effect of tissue fixation, the clinical implication of our results may be inconclusive and more experiments are needed.

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Section: Image Processingmentioning

confidence: 99%

MR elastography and diffusion‐weighted imaging of ex vivo prostate cancer: quantitative comparison to histopathology

et al. 2014

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“…The test objects were placed in a MRE dedicated system (Philips Research, Hamburg, Germany), which is able to induce mechanical vibrations via electrodynamic transducers (12).…”

Section: Pva Phantom Experimentsmentioning

confidence: 99%

“…[15,16]) and ␦⌽ DM ϭ r DM ⅐ ⌽ SM (Eqs. [12,15]). DENSE-MRE, SE-MRE and FEHM spectral properties (sensitivity, specificity) are calculated using Eqs.…”

Section: Spectral Properties Estimation (Experiments and Estimation)mentioning

confidence: 99%

“…DENSE-MRE, SE-MRE and FEHM spectral properties (sensitivity, specificity) are calculated using Eqs. [11,12], (15,16 and 14, respectively). SE-MRE is considered as the MRE "gold standard."…”

Section: Spectral Properties Estimation (Experiments and Estimation)mentioning

confidence: 99%

“…Acquiring images of propagating waves is the principle of dynamic elastography using MRI (8) or ultrasound imaging (9,10). Dynamic MRelastography (MRE) has been successfully applied, for instance, to breast (11,12), liver (13)(14)(15), and brain (16 -18). Transient ultrasound-elastography has been successfully applied to breast (19) and liver (20).…”

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Application of DENSE‐MR‐elastography to the human heart

Robert

Sinkus

Gennisson

et al. 2009

Magnetic Resonance in Med

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Typically, MR-elastography (MRE) encodes the propagation of monochromatic acoustic waves in the MR-phase images via sinusoidal gradients characterized by a detection frequency equal to the frequency of the mechanical vibration. Therefore, the echo time of a conventional MRE sequence is typically longer than the vibration period which is critical for heart tissue exhibiting a short T 2 . Thus, fast acquisition techniques like the so-called fractional encoding of harmonic motions were developed for cardiac applications. However, fractional encoding of harmonic motions is limited since it is two orders of magnitude less sensitive to motion than conventional MRE sequences for low-frequency vibrations. Here, a new sequence is derived from the so-called displacement encoding with stimulated echoes (DENSE) sequence. This sequence is more sensitive to displacement than fractional encoding of harmonic motions, and its spectral specificity is equivalent to conventional MRE sequences. The theoretical spectral properties of this new motion-encoding technique are validated in a phantom and excised pork heart specimen. An excellent agreement is found for the measured displacement fields using classic MRE and displacement encoding with stimulated echoes MRE (8% maximum difference). In addition, initial in vivo results on a healthy volunteer clearly show propagating shear waves at 50 Hz. Thus, displacement encoding with stimulated echoes MRE is a promising technique for motion encoding within short T 2 * materials.

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Breast Magnetic Resonance Imaging (MRI)

Sharma

Jagannathan

2010

Encyclopedia of Magnetic Resonance

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MR elastography of breast lesions: Understanding the solid/liquid duality can improve the specificity of contrast‐enhanced MR mammography

Abstract: The purpose of this analysis is to explore the potential diagnostic gain provided by the viscoelastic shear properties of breast lesions for the improvement of the specificity of contrast enhanced dynamic MR mammography (

Cited by 284 publications

References 42 publications

MR elastography and diffusion‐weighted imaging of ex vivo prostate cancer: quantitative comparison to histopathology

MR elastography and diffusion‐weighted imaging of ex vivo prostate cancer: quantitative comparison to histopathology

Application of DENSE‐MR‐elastography to the human heart

Breast Magnetic Resonance Imaging (MRI)

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