MR Elastography of Breast Cancer: Preliminary Results

McKnight, Alexia L.; Kugel, Jennifer L.; Rossman, Phillip J.; Manduca, Armando; Hartmann, Lynn C.; Ehman, Richard L.

doi:10.2214/ajr.178.6.1781411

Cited by 340 publications

(267 citation statements)

References 26 publications

Supporting

Mentioning

247

Contrasting

Unclassified

Order By: Relevance

“…All of these steps in processing can be applied automatically, without human intervention, to yield quantitative images of tissue shear stiffness, in units of kilopascals. We have used the designation "shear stiffness", rather than "shear modulus" to indicate that the measurements may include a viscous component, although this is likely to be very small at the low driving frequency used (22). The elastograms were analyzed by measuring mean shear stiffness within a large, manually specified region-of interest that included an entire cross-sectional image of hepatic parenchyma, while excluding major blood vessels, such as hepatic veins, main portal veins and branches that have width greater than 6 pixels (about 8 mm).…”

Section: Mr Elastogramsmentioning

confidence: 99%

“…MR Elastography can be readily implemented on standard MR imaging systems with little additional hardware (21). To date, MR Elastography has been applied to quantitatively assess the viscoelastic properties of many human tissues in vivo, including breast, brain, muscle, and liver (22)(23)(24)(25)(26)(27)(28)(29). Preliminary studies in human subjects have confirmed the feasibility and promise of this technique for the quantitative assessment of hepatic fibrosis (27,28).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Assessment of Hepatic Fibrosis With Magnetic Resonance Elastography

Yin

Talwalkar

Glaser

et al. 2007

Clinical Gastroenterology and Hepatology

Self Cite

837

809

View full text Add to dashboard Cite

Background & Aims-Accurate detection of hepatic fibrosis is crucial for assessing prognosis and candidacy for treatment in patients with chronic liver disease. Magnetic Resonance (MR) Elastography, a technique for quantitatively assessing the mechanical properties of soft tissues, has previously been shown to have potential for non-invasively detecting liver fibrosis. The goal of this work was to obtain preliminary estimates of the sensitivity and specificity of the technique in diagnosing liver fibrosis, and to assess its potential for identifying patients who can potentially avoid biopsy.

show abstract

Section: Mr Elastogramsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Assessment of Hepatic Fibrosis With Magnetic Resonance Elastography

Yin

Talwalkar

Glaser

et al. 2007

Clinical Gastroenterology and Hepatology

Self Cite

837

809

View full text Add to dashboard Cite

show abstract

“…[6][7][8][9][10][11][12][13][14][15][16][17][18][19] In MRE, the sample is excited mechanically, and the response is measured with magnetic resonance imaging. The primary goal of the technique is early detection of tissue lesions by determining the elasticity coefficients from the wavelengths of the stress waves.…”

Section: Introductionmentioning

confidence: 99%

High spatial and temporal resolution measurement of mechanical properties in hydrogels by non-contact laser excitation

et al. 2016

View full text Add to dashboard Cite

Gels have received increased attention as potential materials for biological materials because they can exhibit similar mechanical properties. One obstacle for using gels is that their mechanical properties are significantly altered by defects, such as an inhomogeneous crosslink density distribution. If these defects could be detected and the values and spatial distributions of mechanical properties in the gel could be determined, it would be possible to apply gels for several fields. To achieve the high spatial and temporal resolution measurement of mechanical properties in hydrogels, in our method, a conventional contact excitation device is replaced with a non-contact excitation using laser ablation for the input and magnetic resonance elastography to measure stress waves is replaced with the Schlieren method with a high-speed camera. Magnetic resonance elastography is a local measurement technique, and consequently, requires a lot of time to characterize a sample, as well as does not have sufficient spatial resolution to obtain a broad range of elasticity coefficients of gels. We use laser ablation to apply non-contact impulse excitations to gels to generate stress waves inside them. We can determine mechanical properties of gels using the stress waves’ propagation velocity.

show abstract

“…Magnetic Resonance Elastography (MRE) can directly visualise and measure tissue elasticity [5][6][7][8], and has been applied to resolve stiffness characteristics of a variety human tissues and organs, such as muscle [9][10][11][12], breast [13][14][15][16][17], liver [18][19][20] and the brain [21][22][23][24][25][26][27][28][29]. MRE acquisition requires application of mechanical waves to tissue within the MRI, phase-contrast MR pulse sequence extended with motion encoding gradient (MEGs), and sophisticated inverse problem methods to identify an elastic modulus map of the tissue.…”

Section: Introductionmentioning

confidence: 99%