MR Dynamic Enhancement of Breast Lesions: High Temporal Resolution During the First-Minute versus Eight-Minute Study

Sardanelli, Francesco; Rescinito, Giuseppe; Giordano, G; Calabrese, Massimo; Parodi, Roberto

doi:10.1097/00004728-200009000-00011

Cited by 30 publications

(22 citation statements)

References 41 publications

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“…Previously, the presence of increased blood flow in breast tumors has also been demonstrated using positron emission tomography (13), temporally-resolved contrast-enhanced MRI (14)(15)(16)(17), and color Doppler ultrasonography (18). Furthermore, an ipsilateral association between cancer and increased breast vascularity has been demonstrated using conventional MRI (19,20).…”

Section: Discussionmentioning

confidence: 98%

3D vascular mapping of breast using contrast enhanced mri: association of unilateral increased vascularity with ipsilateral breast cancer

Örgüç

Başara²,

Coşkun³

et al. 2012

Diagn Interv Radiol

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Section: Discussionmentioning

confidence: 98%

3D vascular mapping of breast using contrast enhanced mri: association of unilateral increased vascularity with ipsilateral breast cancer

Örgüç

Başara²,

Coşkun³

et al. 2012

Diagn Interv Radiol

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“…Instead of pushing for a better temporal resolution, a better spatial resolution is more important, especially when smaller lesions are detected in routine screening examination. Several studies have shown that if the first postcontrast acquisition can be completed within two minutes after contrast injection, it is sufficient for making a differential diagnosis (37)(38)(39). For detection of very small lesions, a fat-sat high spatial resolution imaging sequence may be preferred over the subtraction technique.…”

Section: Discussionmentioning

confidence: 99%

Correlation of dynamic contrast enhancement MRI parameters with microvessel density and VEGF for assessment of angiogenesis in breast cancer

Cheung

Fruehauf

et al. 2003

Magnetic Resonance Imaging

150

115

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Purpose:To investigate the association between parameters obtained from dynamic contrast enhanced MRI (DCE-MRI) of breast cancer using different analysis approaches, as well as their correlation with angiogenesis biomarkers (vascular endothelial growth factor and vessel density).Materials and Methods: DCE-MRI results were obtained from 105 patients with breast cancer (108 lesions). Three analysis methods were applied: 1) whole tumor analysis, 2) regional hot-spot analysis, and 3) intratumor pixel-by-pixel analysis. Early enhancement intensities and fitted pharmacokinetic parameters were studied. Paraffin blocks of 71 surgically resected specimens were analyzed by immunohistochemical staining to measure microvessel counts (with CD31) and vascular endothelial growth factor (VEGF) expression levels.Results: MRI parameters obtained from the three analysis methods showed significant correlations (P Ͻ 0.0001), but a substantial dispersion from the linear regression line was noted (r ϭ 0.72-0.97). The entire region of interest (ROI) vs. pixel population analyses had a significantly higher association compared to the entire ROI vs. hot-spot analyses. Cancer specimens with high VEGF expression had significantly higher CD31 microvessel densities than did specimens with low VEGF levels (P Ͻ 0.005). No significant association was found between MRI parameters obtained from the three analysis strategies and IHC based measurements of angiogenesis. Conclusion:A consistent analysis strategy was important in the DCE-MRI study. In this series, none of these strategies yielded results for MRI based quantitation of tumor vascularity that were associated with IHC based measurements. Therefore, different analyses could not account for the lack of association.

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“…(1) To achieve precise signal-time curves of contrast agent uptake within lesions, a series of T1-weighted sequences is used [9][10][11][12][13][14][15]. Mostly three-dimensional (3D) gradient recall echo (GRE) sequences with duration of 90 s or less are performed once before and several times after injection of contrast-media (CM).…”

Section: Introductionmentioning

confidence: 99%

Combination of low and high resolution sequences in two orientations for dynamic contrast-enhanced MRI of the breast: more than a compromise

et al. 2004

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The purpose was to combine T1-weighted 3D gradient echo sequences at low and high spatial resolution (and short and longer acquisition time, respectively) in two orientations without compromising signal/time curve analysis and to evaluate the incremental value of assessing architectural features in high resolution images in dynamic contrast-enhanced MR mammography. T1-weighted 3D-FLASH sequences in a 1.5-T scanner (512 x 256 pixel matrix at high resolution; 256 x 128 pixels at low resolution sequences, 72 slices, 1.7-mm slice thickness, TR 8.8 ms, TE 4.5 ms, flip angle 25 degrees) were acquired in a special order during a single investigation. Three observers evaluated architectural features of 36 histopathologically proven lesions using high or low resolution images independently. Architectural features of each lesion were assessed by rating on two three-point scales. Kappa statistics verified the decrease of inter-observer variability. All observers improved assessment of architectural features regarding high resolution images in transversal and coronal orientation (observer A: eight positive, three negative corrections; B: 12/5; C: 16/4). Most positive corrections resulted from improved detection of morphologic criteria of malignancy. Mean inter-observer agreement significantly (P<0.05) increased from "slight" to "moderate" (mean weighted kappa increased from 0.185 to 0.422). This protocol at the charge of slightly enlarged time for measurement offers an elegant way to improve analysis of architectural features in MRM.

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MR Dynamic Enhancement of Breast Lesions: High Temporal Resolution During the First-Minute versus Eight-Minute Study

Abstract: The first minute of Gd-enhancement allows a more prominent differentiation between malignant and benign breast lesions than the following times.

Cited by 30 publications

References 41 publications

3D vascular mapping of breast using contrast enhanced mri: association of unilateral increased vascularity with ipsilateral breast cancer

3D vascular mapping of breast using contrast enhanced mri: association of unilateral increased vascularity with ipsilateral breast cancer

Correlation of dynamic contrast enhancement MRI parameters with microvessel density and VEGF for assessment of angiogenesis in breast cancer

Combination of low and high resolution sequences in two orientations for dynamic contrast-enhanced MRI of the breast: more than a compromise

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