MR compatible positioning device for guiding a focused ultrasound system for the treatment of brain deseases

Mylonas, Nicos; Damianou, Christakis

doi:10.1002/rcs.1501

Cited by 36 publications

(45 citation statements)

References 43 publications

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“…The appearance of these lesions was demonstrated using MRI and proved that the linear stages moved with great accuracy. The degree of accuracy of the linear stages was also demonstrated in other articles of our group (for example, [12, 20, 21]). In future experiments, we plan to use thicker gel phantoms, in order to create lesions in a model which is closer to the size of anatomy involved for the case of fibroids.…”

Section: Discussionsupporting

confidence: 76%

“…Such system were developed for brain ablation using three Cartesian axes [12], prostate ablation using one linear and one angular axis [20, 21], and gynecological tumor ablation using one linear and one angular axis [22]. …”

Section: Discussionmentioning

confidence: 99%

“…An existing positioning device with three axes ( X , Y , Z ) was used [12]. Figure 1 shows the existing robotic system dedicated for the brain.…”

Section: Methodsmentioning

confidence: 99%

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MRI-guided coupling for a focused ultrasound system using a top-to-bottom propagation

et al. 2017

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BackgroundA novel magnetic resonance imaging (MRI)-conditional coupling system was developed that accommodates a focused ultrasound (FUS) transducer. With this coupling system, the transducer can access targets from top to bottom. The intended clinical application is treatment of fibroids using FUS with the patient placed in supine position.MethodsThe coupling system was manufactured using a rapid prototyping device using acrylonitrile butadiene styrene (ABS) plastic. Coupling to a gel phantom was achieved using a water bag filled with degassed water. The FUS transducer was immersed in the water bag.ResultsThe coupling system was successfully tested for MRI compatibility using fast-gradient pulse sequences in a gel phantom. The robotic system with its new coupling system was evaluated for its functionality for creating discrete and multiple (overlapping) lesions in the gel phantom.ConclusionsAn MRI-conditional FUS coupling system integrated with an existing robotic system was developed that has the potential to create thermal lesions in targets using a top-to-bottom approach. This system has the potential to treat fibroid tumors with the patient lying in supine position.

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Section: Discussionsupporting

confidence: 76%

Section: Discussionmentioning

confidence: 99%

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MRI-guided coupling for a focused ultrasound system using a top-to-bottom propagation

et al. 2017

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“…The United States Food and Drug Administration (FDA) and the American Society for Testing and Materials (ASTM) define three levels of MRI device classification: MR safe (safe to use in all MR environments), MR unsafe (poses a risk to the patient or the operator) and MR conditional (safe to use in a specific MR-environment). 15,16 Damianou et al 17,18 have developed a 3 DOF robotic FUS transducer positioning system using predominantly plastic and MR-compatible stainless steels, driven by piezoelectric motors. The system can target abdominal organs or the brain through a window in the skull created with a craniotomy.…”

Section: Introductionmentioning

confidence: 99%

Design and validation of an MR‐conditional robot for transcranial focused ultrasound surgery in infants

et al. 2016

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This paper presents a comprehensive look at the process of designing and validating a new robot from concept to implementation for use in an MR environment. An MR conditional robot has been designed and manufactured to design specifications. The system has demonstrated its feasibility as a platform for MRgFUS interventions for neonatal patients. The success of the system in experimental trials suggests that it is ready to be used for validation of the transcranial intervention in animal studies.

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“…An existing positioning device with three axes (X,Y,Z) was used . A fourth axis was added in order to move the transducer angularly.…”

Section: Methodsmentioning

confidence: 99%

MRI‐compatible breast/rib phantom for evaluating ultrasonic thermal exposures

Menikou

Yiannakou

Yiallouras

et al. 2017

Robotics Computer Surgery

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MR compatible positioning device for guiding a focused ultrasound system for the treatment of brain deseases

Abstract: A simple, cost effective, portable positioning device has been developed which can be used in virtually any clinical MRI scanner since it can be placed on the table of the MRI scanner. This system can be used to treat in the future patients with brain cancer and ischemic stroke.

Cited by 36 publications

References 43 publications

MRI-guided coupling for a focused ultrasound system using a top-to-bottom propagation

MRI-guided coupling for a focused ultrasound system using a top-to-bottom propagation

Design and validation of an MR‐conditional robot for transcranial focused ultrasound surgery in infants

MRI‐compatible breast/rib phantom for evaluating ultrasonic thermal exposures

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