MR Cholangiography in the Evaluation of Hepatic and Biliary Abnormalities in Autosomal Dominant Polycystic Kidney Disease: Study of 93 Patients

Dranssart, M.; Cognet, F.; Mousson, Christiane; Cercueil, Jean-Pierre; Rifle, G; Krausé, D.

doi:10.1097/00004728-200203000-00013

Cited by 16 publications

(8 citation statements)

References 16 publications

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“…Peribiliary cysts were reported in 41 of 56 patients (18) and 59 of 90 patients (19) in the two large imaging series mentioned earlier. These cysts arise from dilated peribiliary glands (2); are typically less than 10 mm in diameter; and appear as either discrete cysts, a string of cysts, or tubular structures paralleling the path of the portal vessels (7,18,19). Identification of dominant cysts that may be amenable to temporizing percutaneous aspiration and sclerosis is helpful in symptomatic patients ( Fig 6); this therapy is often repeated over a period of years before ultimately choosing transplantation as a therapeutic option.…”

Section: Imaging Findings Cystsmentioning

confidence: 78%

“…These cysts arise from von Meyenburg complexes and are mostly peripheral, ranging from less than 10 mm to 80 mm in size (7). Peribiliary cysts were reported in 41 of 56 patients (18) and 59 of 90 patients (19) in the two large imaging series mentioned earlier. These cysts arise from dilated peribiliary glands (2); are typically less than 10 mm in diameter; and appear as either discrete cysts, a string of cysts, or tubular structures paralleling the path of the portal vessels (7,18,19).…”

Section: Imaging Findings Cystsmentioning

confidence: 85%

“…Two types of cysts may be found in the livers of patients with PLD: intrahepatic cysts and peribiliary cysts ( Fig 5). Intrahepatic cysts are more common, being found in 56 of 64 patients in one series (18) and in 84 of 93 patients in another (19). These cysts arise from von Meyenburg complexes and are mostly peripheral, ranging from less than 10 mm to 80 mm in size (7).…”

Section: Imaging Findings Cystsmentioning

confidence: 99%

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Polycystic Liver Disease: Multimodality Imaging for Complications and Transplant Evaluation

Morgan¹,

Lockhart²,

Canon³

et al. 2006

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Polycystic liver disease (PLD) is usually associated with polycystic kidney disease but may also occur as an isolated finding in a rarer genetically distinct disease. In either case, the cyst burden will progress over time and, in rare cases, may affect liver function or become symptomatic due to massive hepatomegaly. The character, distribution, location, and size of hepatic cysts are important. Computed tomography, magnetic resonance imaging, or ultrasonography may provide the surgeon with valuable preoperative information, such as the location of infected or hemorrhagic cysts that may be responsible for symptoms. Less invasive cyst aspiration or fenestration may provide temporary relief from dominant or symptomatic cysts, but these cysts will recur in up to 75% of patients. Cyst fenestration with partial hepatic resection and liver transplantation are two therapies that provide more permanent resolution of symptoms in patients with extensive hepatic involvement. However, the higher risk of complications associated with more aggressive surgical therapy must be considered when determining the appropriate therapy for a given patient. Knowledge of the cyst patterns and available treatment options in patients with PLD will help the radiologist provide the referring clinician with important information for therapeutic decision making.

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Section: Imaging Findings Cystsmentioning

confidence: 78%

Section: Imaging Findings Cystsmentioning

confidence: 85%

Section: Imaging Findings Cystsmentioning

confidence: 99%

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Polycystic Liver Disease: Multimodality Imaging for Complications and Transplant Evaluation

Morgan¹,

Lockhart²,

Canon³

et al. 2006

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“…Common bile duct dilation is prevalent (40%) in patients with PKD [ 21 ]. Dranssart et al observed intrahepatic bile duct abnormalities in 27.8% of the patients with PKD, which correlated with the results of hepatobiliary infection [ 22 ]. A case report described the presence of multifocal cystic dilatation of the intrahepatic bile ducts, such as Caroli's disease, in patients with PKD [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

Hepatointestinal complications in polycystic kidney disease

Huang

Chuang

et al. 2017

Oncotarget

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BackgroundThe objective of this study was to determine the incidence of major hepatointestinal complications in patients with polycystic kidney disease (PKD).MethodsWe analyzed the Taiwan National Health Insurance claims data (2000–2010) of 6031 patients with PKD and 23,976 non-PKD hospitalized controls. The control cohort was propensity score matched with the PKD cohort at a 1:4 ratio. All patients were followed up from the index date to the first inpatient diagnosis of hepatointestinal complications, death, or 31 December, 2011. Cox proportional hazard regression models were used to identify the risk of outcome after adjustment for potential confounders.ResultsThe incidence rates of acute pancreatitis, cholangitis, peptic ulcer bleeding, and cirrhosis were 5.72, 4.01, 19.9, and 5.46 per 1000 person-years, respectively, in the PKD cohort. Compared with the non-PKD controls, patients with PKD exhibited an increased risk of hospitalization for acute pancreatitis, cholangitis, peptic ulcer bleeding, and cirrhosis (adjusted subhazard ratio [aSHR]: 2.36, 95% confidence interval [95% CI], 1.95–2.84]; 2.36, [95% CI, 1.95–2.84]; 2.41, [95% CI, 1.93–3.01]; 2.41, [95% CI, 2.17–2.67]; and 1.39, [95% CI, 1.16–1.66], respectively; all p < 0.001). PKD, chronic kidney disease, and alcoholism were independent predictors of all these hepatointestinal complications. Kaplan–Meier analysis revealed an increased overall mortality in patients with PKD who developed acute pancreatitis and peptic ulcer bleeding (log-rank p < 0.05).ConclusionPKD is associated with clinically significant extrarenal complications including acute pancreatitis, cholangitis, peptic ulcer bleeding, and cirrhosis.

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“…MRCP is essential for the accurate estimation of obstruction level and the depiction of the characteristic morphologic features of stenosis or obstruction (abrupt termination of the bile duct as in our case) [14]. Because of their intrinsic high tissue contrast and multiplanar capability, MRI and MRCP are able to detect and preoperatively assess patients with cholangiocarcinoma, investigating all involved structures such as bile ducts, vessels and hepatic parenchyma.…”

Section: Discussionmentioning

confidence: 99%

Obstructive Jaundice in Polycystic Liver Disease Related to Coexisting Cholangiocarcinoma

Delis¹,

Bakoyiannis²,

Triantopoulou³

et al. 2008

Case Rep Gastroenterol

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Although jaundice rarely complicates polycystic liver disease (PLD), secondary benign or malignant causes cannot be excluded. In a 72-year-old female who presented with increased abdominal girth, dyspnea, weight loss and jaundice, ultrasound and computed tomography confirmed the diagnosis of PLD by demonstrating large liver cysts causing extrahepatic bile duct compression. Percutaneous cyst aspiration failed to relief jaundice due to distal bile duct cholangiocarcinoma, suspected by magnetic resonance cholangiopancreatography (MRCP) and confirmed by endoscopic retrograde cholangiopancreatography (ERCP). Coexistence of PLD with distal common bile duct cholangiocarcinoma has not been reported so far.

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MR Cholangiography in the Evaluation of Hepatic and Biliary Abnormalities in Autosomal Dominant Polycystic Kidney Disease: Study of 93 Patients

Abstract: This study confirms the complexity of hepatobiliary involvement in ADPKD. Various types of cystic lesions can arise, and patients with IHBD abnormalities are at increased risk for hepatobiliary infection.

Cited by 16 publications

References 16 publications

Polycystic Liver Disease: Multimodality Imaging for Complications and Transplant Evaluation

Polycystic Liver Disease: Multimodality Imaging for Complications and Transplant Evaluation

Hepatointestinal complications in polycystic kidney disease

Obstructive Jaundice in Polycystic Liver Disease Related to Coexisting Cholangiocarcinoma

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