MR angiography with gadopentetate dimeglumine-polylysine: evaluation in rabbits.

Marchal, Guy; Bosmans, Hilde; Hecke, Paul Van; Speck, Ulrich; Aerts, P; Vanhoenacker, Peter; Baert, A L

doi:10.2214/ajr.155.2.2115276

Cited by 57 publications

(14 citation statements)

References 4 publications

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“…WIN 22181is a modelsubstance thatbelongsin the class of solubleTI blood pool agents.This pro totype agent is composed of a linear copolymer of DTPA and 1,6-hexanediamine chelated with gad olinium (@3J3@) resulting in a molecular weight of 18.9kd and an rl of 9.5 l.mmol1.sect at 20 Previous tests in rodents revealed minimal acute and subacute toxicity for either contrast agent. The median lethal dose ofFeO-BPA is more than 100 times greater than the imaging dose.…”

Section: Win 22181mentioning

confidence: 99%

Abdominal MR angiography performed using blood pool contrast agents: comparison of a new superparamagnetic iron oxide nanoparticle and a linear gadolinium polymer.

Nolte-Ernsting

Adam²,

Bücker³

et al. 1998

American Journal of Roentgenology

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OBJECTIVE.We evaluatedandcomparedtwo differentexperimentalbloodpool contrast agents for abdominal MR angiography in an animal model. MATERIALS AND METHODS.Inseven pigs, coronal Ti-weighted three-dimensionalfast field-echo images were obtained on a conventional 1.5-T MR imaging system before and after IV injection of the ultrasmall superparamagneticiron oxide agent FeO-BPA. In another seven pigs. MR angiograms were acquired using the gadolinium polymer WIN 22181 . En hanced images were obtained 5â€"210mm after injection of FeO-BPA and 1â€"120mm after in jection ofWIN 22181. RESULTS. Bothblood pool agents yielded detailed angiograms oftheabdominal vasculartree when imaging lasted 2 mm. In-plane running vessels were imaged without saturation ef fects and with equivalent maximum signal-to-noise ratios. Half the maximum signal-to-noise ratio was reached 150 mm after injection of FeO-BPA, whereas this interval was approxi mately 70 mm for the gadolinium polymer. Because of these different imaging half-life peri ods, the effective diagnostic window provided by FeO-BPA was six to eight times longer than that ofWlN 22181. In the liver, the vascularTl shortening and the parenchymal T2* effect of FeO-BPA complemented each other, resulting in an optimal contrast-to-noise ratio signifi cantly higher than that achieved with WIN 22 18 1. This â€oe¿ double-contrast effectâ€•in the liver was especially helpful when obtaining detailed MR portograms. CONCLUSION.The blood pool agents FeO-BPA and WIN 22181 can be used to pro duce high-quality abdominal MR angiograms on standard MR imaging equipment. The con trast-to-noise ratio of hepatic vessels is best on iron oxideâ€"enhanced images because of a Tl_T2* synergistic effect in the liver. The longer diagnostic window provided by FeO-BPA coupled with the option of in-plane imaging suggests the usefulness of FeO-BPA in future MR imagingâ€"guided vascular interventions. All contrastmaterialsinvestigated inthis studywere suppliedbyNycomedImagingAS,Oslo,Norway.

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Section: Win 22181mentioning

confidence: 99%

Abdominal MR angiography performed using blood pool contrast agents: comparison of a new superparamagnetic iron oxide nanoparticle and a linear gadolinium polymer.

Nolte-Ernsting

Adam²,

Bücker³

et al. 1998

American Journal of Roentgenology

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“…These characteristics make them interesting as blood pool agents. Gd 3+ -dTpA-p-Lys was used in MR angiography in rabbits to monitor blood flow in the extremities, allowing visualization of vessels smaller than 1 mm [44], or to visualize lung lesions exhibiting abnormal blood flow [45][46][47]. Furthermore, Gd 3+ -dTpA-p-Lys was shown to accumulate in tumors and produced a contrast enhancement of approximately 300% lasting for several days in rat [48].…”

Section: Enhanced Relaxivity and Circulation Timementioning

confidence: 99%

MRI with Gadolinium‐Based Nanoparticles

Guérard

Ray

Brechbiel

2014

Nanotechnology for Biomedical Imaging and Diagnostics

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“…Hence the relaxivity of paramagnetic agents is generally enhanced by tuning the various parameters, such as rotational correlation time Tr (tumbling time of CA in water), water proton residence time TM (exchange rate of single inner coordinated water molecule with the bulk water) and electron spin relaxation time Te, related to inner sphere interaction 45) . Relaxivity of the protons associated with inner sphere can be increased by increasing the tumbling time of CA which can be achieved by increasing the effective size of the CA either by using polymer or dendrimer scaffold [46][47][48][49][50][51][52][53] or by conjugating them with slowly tumbling macromolecules 54) . Relaxivity can also be increased by decreasing the TM which depends on the coordination number, charge and geometr y of the paramagnetic CA.…”

Section: Paramagnetic Camentioning

confidence: 99%