MR angiography and surgery for unruptured familial intracranial aneurysms in persons with a family history of cerebral aneurysms.

Brown, B.; Soldevilla, Fernando Alarcón

doi:10.2214/ajr.173.1.10397113

Cited by 29 publications

(8 citation statements)

References 26 publications

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“…7 Brown and Soldevilla found 6 of 63 (9.5%) apparently unaffected individuals with a first degree relative with an IA had an IA documented by MRA and cerebral angiography. 8 Nakagawa et al found 34 of 244 (13.9%) apparently unaffected first or second degree relatives of an SAH patient had an unruptured IA identified by MRA or CT angiography. 9 Different approaches have been used to identify the genetic factors increasing the risk for IA.…”

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confidence: 99%

Genome Screen to Detect Linkage to Intracranial Aneurysm Susceptibility Genes

Foroud

Sauerbeck

Brown

et al. 2008

Stroke

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the FIA Study InvestigatorsBackground and Purpose-Evidence supports a substantial genetic contribution to the risk of intracranial aneurysm (IA).The purpose of this study was to identify chromosomal regions likely to harbor genes that contribute to the risk of IA. Methods-Multiplex families having at least 2 individuals with "definite" or "probable" IA were ascertained through an international consortium. First-degree relatives of individuals with IA who were at increased risk of an IA because of a history of hypertension or present smoking were offered cerebral magnetic resonance angiography. A genome screen was completed using the Illumina 6K SNP system, and the resulting data from 192 families, containing 1155 genotyped individuals, were analyzed. Narrow and broad disease definitions were used when testing for linkage using multipoint model-independent methods. Ordered subset analysis was performed to test for a geneϫsmoking (pack-years) interaction. Results-The greatest evidence of linkage was found on chromosomes 4 (LODϭ2.5; 156 cM), 7 (LODϭ1.7; 183 cM), 8 (LODϭ1.9; 70 cM), and 12 (LODϭ1.6; 102 cM) using the broad disease definition. Using the average pack-years for the affected individuals in each family, the genes on chromosomes 4 (LODϭ3.5; Pϭ0.03), 7 (LODϭ4.1; Pϭ0.01) and 12 (LODϭ3.6; Pϭ0.02) all appear to be modulated by the degree of smoking in the affected members of the family. On chromosome 8, inclusion of smoking as a covariate did not significantly strengthen the linkage evidence, suggesting no interaction between the loci in this region and smoking. Conclusions-We have detected possible evidence of linkage to 4 chromosomal regions. There is potential evidence for a geneϫsmoking interaction with 3 of the loci.

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confidence: 99%

Genome Screen to Detect Linkage to Intracranial Aneurysm Susceptibility Genes

Foroud

Sauerbeck

Brown

et al. 2008

Stroke

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“…First degree relatives of SAH patients have 3–5 times higher risk of SAH than the general population 5. Furthermore, it is estimated that about 9% of first degree relatives to patients suffering from SAH/IA harbour an unruptured IA,6 7 whereas the population frequency is approximately 2% 8…”

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confidence: 99%

Association between genetic variation on chromosome 9p21 and aneurysmal subarachnoid haemorrhage

Olsson

Csajbok

Jood

et al. 2010

Journal of Neurology, Neurosurgery & Psychiatry

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“…3–6 First and second degree relatives of an SAH or IA patient also have a greater risk of an unruptured IA (8.7% – 13.9%), compared with the general population (1%). 7–9 These data support a genetic contribution but could also be due to common life-style related risk factors.…”

Section: Introductionmentioning

confidence: 55%

Genome-Wide Association Study of Intracranial Aneurysm Identifies a New Association on Chromosome 7

Foroud

Lai

Koller

et al. 2014

Stroke

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Background and Purpose Common variants have been identified using genome-wide association studies which contribute to intracranial aneurysms (IA) susceptibility. However, it is clear that the variants identified to date do not account for the estimated genetic contribution to disease risk. Methods Initial analysis was performed in a discovery sample of 2,617 IA cases and 2,548 controls of Caucasian ancestry. Novel chromosomal regions meeting genome-wide significance were further tested for association in two independent replication samples: Dutch (717 cases; 3,004 controls) and Finnish (799 cases; 2,317 controls). A meta-analysis was performed to combine the results from the three studies for key chromosomal regions of interest. Results Genome-wide evidence of association was detected in the discovery sample on chromosome 9 (CDKN2BAS; rs10733376: p< 1.0 × 10−11), in a gene previously associated with IA. A novel region on chromosome 7, near HDAC9, was associated with IA (rs10230207; p= 4.14 × 10−8). This association replicated in the Dutch sample (p=0.01), but failed to show association in the Finnish sample (p=0.25). Meta-analysis results of the three cohorts reached statistical significant (p=9.91 × 10−10). Conclusions We detected a novel region associated with IA susceptibility that was replicated in an independent Dutch sample. This region on chromosome 7 has been previously associated with ischemic stroke and the large vessel stroke occlusive subtype (including HDAC9), suggesting a possible genetic link between this stroke subtype and IA.

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MR angiography and surgery for unruptured familial intracranial aneurysms in persons with a family history of cerebral aneurysms.

Cited by 29 publications

References 26 publications

Genome Screen to Detect Linkage to Intracranial Aneurysm Susceptibility Genes

Genome Screen to Detect Linkage to Intracranial Aneurysm Susceptibility Genes

Association between genetic variation on chromosome 9p21 and aneurysmal subarachnoid haemorrhage

Genome-Wide Association Study of Intracranial Aneurysm Identifies a New Association on Chromosome 7

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