MR and PET/CT imaging use to stratify cardiovascular risks in non-human primates under atherogenic diet

Cataldo, V. Di; Agudelo, Jose; Contamin, Hugues; Géloën, Alain; Grandin, C.; Sérusclat, André; Lamberton, Franck; Ibarolla, D.; Lávenne, F.; Bars, Didier Le; Canet-Soulas, E.

doi:10.1016/j.atherosclerosis.2015.04.841

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2016

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“…In particular, the local lesion and its evolution could be monitored using a carotid MRI protocol, considering the vessel wall permeability on gadolinium-enhanced MRI 5 . Under high cholesterol diet, old NHP had at-risk plasmatic profile (high LDL/HDL ratio, high triglycerides (see Table S3 ) and high hsCRP levels) and developped atherosclerosis lesions similar to human plaques at the same vascular sites 25 . As shown by MRI, our animals had carotid plaques with the same advanced and vulnerable characteristics as in patients.…”

Section: Discussion – Conclusionmentioning

confidence: 99%

Safety Evaluation and Imaging Properties of Gadolinium-Based Nanoparticles in nonhuman primates

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Lamberton

et al. 2016

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In this article, we report the safety evaluation of gadolinium-based nanoparticles in nonhuman primates (NHP) in the context of magnetic resonance imaging (MRI) studies in atherosclerosis bearing animals and healthy controls. In healthy NHP, the pharmacokinetics and toxicity profiles demonstrated the absence of dose, time, and sex-effects, as well as a suitable tolerance of intravenous administration of the nanoparticles. We investigated their imaging properties for arterial plaque imaging in a standard diet or a high cholesterol diet NHP, and compared their characteristics with clinically applied Gd-chelate. This preliminary investigation reports the efficient and safe imaging of atherosclerotic plaques.

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Section: Discussion – Conclusionmentioning

confidence: 99%