MPR and NLR as Prognostic Markers in ICU-Admitted Patients with COVID-19 in Jazan, Saudi Arabia

Mobarki, Abdullah A; Dobie, Gasim; Saboor, Muhammad; Madkhali, Aymen M; Akhter, Muhammad Saleem; Hakamy, Ali; Humran, Adel; Hamali, Yousof; Jackson, Denise E.; Hamali, Hassan A

doi:10.2147/idr.s342259

Cited by 9 publications

(15 citation statements)

References 44 publications

(57 reference statements)

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“…For example, in a previous study elevated NLR and MPR were found to be associated with mortality. 19 Consistenly, our study supported that these hemogram based parameters were significantly higher in mortal cases compared with survived ones.…”

Section: Discussionsupporting

confidence: 79%

“…5 Apart from NLR, many other inflammatory parameters showing systemic inflammation were found to be useful in predicting mortality in COVID-19 patients. [19][20][21][22][23][24][25][26][27][28][29] The common mechanism of the effect of these parameters to the disease mortality is that systemic inflammation has a crucial role in the pathogenesis and mortality of COVID-19. 6,8 Hemogram based inflammatory parameters were previously investigated in COVID-19 patients.…”

Section: Discussionmentioning

confidence: 99%

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Multi-inflammatory Index as a Novel Mortality Predictor in Critically Ill COVID-19 Patients

Gözdaş

Kayış

Damarsoy

et al. 2022

J Intensive Care Med

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Aim Systemic inflammation has a crucial role in the pathogenesis and mortality of Coronavirus disease 2019 (COVID-19). Multi-inflammatory index (MII) is a novel index related with systemic inflammation. In this study, we investigated the relationship between MII and in-hospital mortality in COVID-19 patients admitted to the intensive care unit (ICU). Methods We retrospectively analyzed the medical records of COVID-19 patients followed-up in the ICU of our institution between 01.04.2020 and 01.10.2021. Patients were classified into two groups according to mortality status as survivors and non-survivors. Various inflammatory parameters of the groups were compared and their efficacy in predicting mortality was investigated. Results Out of 348 study patients, 86 cases (24.7%) were in the survived group and 262 cases (75.3%) were in the dead group. The median age of the mortal group was significantly higher than that of the survived group (65.5 vs 76, P < .001). Multiple logistic regression analysis revealed that among all the included inflammatory parameters, MII showed the best efficacy for predicting mortality (OR: 0.999; 95% CI: 0.9991-0.9998; P = .003). Conclusion MII, a new combination of Neutrophil to lymphocyte ratio (NLR) and C-reactive protein (CRP), is a simple and practical biomarker that can help us in the prediction of mortality in COVID-19 patients followed-up in the ICU.

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Section: Discussionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Multi-inflammatory Index as a Novel Mortality Predictor in Critically Ill COVID-19 Patients

Gözdaş

Kayış

Damarsoy

et al. 2022

J Intensive Care Med

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“…of MPV or platelet indices alone in non-COVID-19 ICU patients (17). A small-series study evaluating the admission parameters of 96 ICU patients in the COVID-19 patient group found no difference between non-survivors and survivors in terms of the admission MPV value but reported the significance of the MPV/ PLT ratio in demonstrating mortality (18). The study of Yardimci et al (19) evaluating 722 patients hospitalized in COVID-19 wards reported that 44 patients were transferred to ICU and the MPV/PLT ratio of severely ill patients who required ICU were higher compared to those treated in wards.…”

Section: Discussionmentioning

confidence: 99%

Platelet-to-lymphocyte ratio and mean platelet volume-to-platelet count ratio for predicting mortality in critical COVID-19 patients

Dal

YALNIZ>

TOSUN

et al. 2022

Journal of Health Sciences and Medicine

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Introduction: Defining the markers that can be used in clinical practice for predicting the mortality of critical patients will be cautionary for taking necessary measures in high-risk cases. Although there are a large number of studies conducted during the pandemic, no mortality marker to predict the prognosis of intensive care unit (ICU) patients with COVID-19 has yet been defined. Platelet indices can be easily evaluated with a complete blood count (CBC) analysis, one of the most accessible tests worldwide. This study aimed to evaluate the role of platelet indices such as mean platelet volume (MPV), platelet distribution width (PDW), plateletcrit (PCT), platelet-to-lymphocyte ratio (PLR), and MPV-to-platelet count ratio (MPV/PLT) in predicting the mortality of ICU patients with COVID-19. Material and Method: This single-center, retrospective, cross-sectional study included 201 critical COVID-19 patients over 18 years of age who were hospitalized in ICU between August 2020 and February 2021. Patients were divided into two groups as survivors and non-survivors. The relationship of MPV, PDW, PCT, PLR, and MPV/PLT parameters evaluated at ICU admission with mortality was investigated. Results: There was no significant difference between the survivor and non-survivor groups in terms of platelet count, MPV, PCT, and PDW. The comparison of the platelet ratios revealed higher PLR and MPV/PLT ratio in the non-survivor group than in the survivor group (p

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“…8,[11][12][13][14] Complete blood count (CBC) parameters and CBCcalculated parameters, such as the neutrophil-tolymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), platelet-to-neutrophil ratio (PNR), and mean platelet volume to platelet count ratio (MPR), are useful indicators for diagnosing and predicting the severity and prognosis of COVID-19. [15][16][17][18] Furthermore, elevated NLR, PLR, and MPR values were observed in COVID-19 patients who passed away (PA) in the intensive care unit (ICU) compared to COVID-19 patients who were discharged (DC) from the ICU. 18,19 Therefore, this study aims (i) to assess the levels of soluble endothelial markers, specifically E-selectin, ICAM, and VCAM, in the plasma of COVID-19 patients who were either DC from ICU or PA in the ICU and compare overall COVID-19 patients to healthy controls (ii) to correlate soluble endothelial markers levels with CBC parameters including neutrophils, platelets, D-dimer, and CBCcalculated parameters (iii) to investigate the association between the soluble endothelial markers, CBC parameters, CBC-calculated parameters, coagulation profiles, and the clinical outcome of COVID-19.…”

Section: Introductionmentioning

confidence: 99%

Correlation of circulating endothelial markers in COVID-19 patients admitted to the intensive care unit with laboratory data

Hakami,

Dobie,

Mobarki

et al. 2023

Eur J Inflamm

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is still a global concern with high morbidity and mortality rates. The role of endothelial cells in the progress of COVID-19 is well established. Therefore, the current study aimed to measure the endothelial markers and their correlation with the hematological parameters in intensive care unit-admitted COVID-19 patients. This study involved 111 adult participants, including 55 ICU-admitted patients with COVID-19 and 56 healthy controls. Levels of E-selectin, ICAM-1, and VCAM-1 in the plasma of the study participants were measured and correlated with hematological parameters. The study demonstrates that COVID-19 patients admitted to the ICU have higher levels of E-selectin, ICAM-1, and VCAM-1 compared to healthy controls ( p < .05). These elevated levels can serve as reliable indicators of endothelial dysfunction and early markers for the detection and prediction of endothelial cell involvement in COVID-19 complications. The findings of this study suggest that increased levels of E-selectin, VCAM-1, and ICAM-1 in patients with COVID-19 are indicative of the participation of endothelial cells in the pathogenesis of COVID-19 complications. Consequently, these endothelial markers are proposed as potential early indicators for predicting the severity of COVID-19.

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MPR and NLR as Prognostic Markers in ICU-Admitted Patients with COVID-19 in Jazan, Saudi Arabia

Cited by 9 publications

References 44 publications

Multi-inflammatory Index as a Novel Mortality Predictor in Critically Ill COVID-19 Patients

Multi-inflammatory Index as a Novel Mortality Predictor in Critically Ill COVID-19 Patients

Platelet-to-lymphocyte ratio and mean platelet volume-to-platelet count ratio for predicting mortality in critical COVID-19 patients

Correlation of circulating endothelial markers in COVID-19 patients admitted to the intensive care unit with laboratory data

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