MPO-ANCA-positive conversion and microscopic polyangiitis development in idiopathic interstitial pneumonia: a case report

Nakayama, Shinichi; Endo, Akihiko; Hirose, Takuo; Matsumoto, Keiji; Kamada, Ayaka; Ito, Hiroki; Hashimoto, H.; Ishiyama, Katsuya; Oba-Yabana, Ikuko; Kimura, Tomoyoshi; Nakamura, H.; Ebina, Masahito; Mori, Takefumi

doi:10.1007/s13730-022-00717-y

Cited by 1 publication

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“…Recently, Nakayama et al published a summary of nine previously reported cases and their own case involving IP, which exhibited conversion to MPO-ANCA-positivity and MPA. The period between idiopathic IP and the development of MPA ranged from 5 to 99 months, and renal vasculitis was observed in nine of ten cases ( 9 ). It has been suggested that chronic inflammation in pulmonary fibrosis could lead to MPO-ANCA production due to neutrophil destruction, possibly explaining the emergence of ANCA following the onset of ILD ( 10 ).…”

Section: Discussionmentioning

confidence: 99%

Slowly Progressive ANCA-associated Glomerulonephritis with Strong Mesangial MPO Deposits Following a Diagnosis of Interstitial Lung Disease

Anzai,

Suzuki,

Ueno

et al. 2024

Intern. Med.

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An elderly woman showed positive conversion of myeloperoxidase (MPO)-antineutrophil cytoplasmic antibodies (ANCAs) following the diagnosis of interstitial lung disease (ILD) and glomerular hematuria and subsequently experienced slowly progressive glomerulonephritis. A kidney biopsy revealed chronic damage and necrotizing crescentic glomerulonephritis with mesangial MPO deposits. After corticosteroid treatment, the patient's urinalysis results and MPO-ANCA titers almost normalized and her renal function stabilized. This case is similar to recently reported cases of slowly progressive ANCA-associated glomerulonephritis. ILD likely triggered the production of MPO-ANCAs, and the accumulation of MPO deposits in the glomeruli may have contributed to the progression of her renal disease.

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Section: Discussionmentioning

confidence: 99%