MPI Phantom Study with A High-Performing Multicore Tracer Made by Coprecipitation

Kratz, Harald; Mohtashamdolatshahi, Azadeh; Eberbeck, Dietmar; Kosch, Olaf; Hauptmann, R.; Wiekhorst, Frank; Taupitz, Matthias; Hamm, Bernd; Schnorr, Jörg

doi:10.3390/nano9101466

Cited by 17 publications

(23 citation statements)

References 55 publications

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“…Images of IVC reconstructed at the time of peak of bolus or nearly after (t 1 ) showed similar adequate image quality (Supplement S1) except for Resovist at dosage of 0.025 mmol Fe/Kg, where the IVC image provided adequate image quality only at time of peak of bolus. The contributing factors in the image quality in images of MCP 3 in comparison to Resovist are the higher signal amplitude and slower drop of higher harmonics (Supplement S2) 14 .…”

Section: Resultsmentioning

confidence: 99%

“…Similar to conventional www.nature.com/scientificreports/ CT-angiography, variations in reconstruction parameters can alter the D L measurement. Standardized set of reconstruction parameters, based on previous phantom studies 14 were applied for all examinations to maintain results comparable and reliable. Nevertheless, the obtained values of AA D L and IVC D L are in good agreement with the literature 25 .…”

Section: Discussionmentioning

confidence: 99%

“…MCP 3 was developed in-house as an MPI tracer coated with carboxymethyl dextran (CMD). The mean diameter of MCP cores is 32 nm (TEM) and the mean hydrodynamic diameter (D H ) is 53 nm (DLS) 14 . The blood half-life of MCP in rats has been determined with MRI, 8.8 and 17.4 min at 0.05 and 0.1 mmol Fe/kg 16 .…”

Section: Methodsmentioning

confidence: 99%

“…D L of the IVC and AA were determined from separated vessels in images. To this end, vessel cross-sections were segmented in two-dimensional planes using basic intensity-based segmentation with a cutoff threshold of 30% maximum intensity 14 . The cross-sectional area was calculated as the sum of the number of all pixels in the segmented area multiplied by voxel size in transverse direction.…”

Section: Methodsmentioning

confidence: 99%

“…This study introduces newly developed multicore nanoparticle (MCP 3) 14 as tracers for cardiovascular MPI. To this end, we administered the new tracers into the tail vein of rats and then performed imaging in a commercial in vivo MPI system.…”

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confidence: 99%

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In vivo magnetic particle imaging: angiography of inferior vena cava and aorta in rats using newly developed multicore particles

Mohtashamdolatshahi

Kratz

Kosch

et al. 2020

Sci Rep

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Magnetic Particle Imaging (MPI) is a new imaging modality, which maps the distribution of magnetic nanoparticles (MNP) in 3D with high temporal resolution. It thus may be suited for cardiovascular imaging. Its sensitivity and spatial resolution critically depend on the magnetic properties of MNP. Therefore, we used novel multicore nanoparticles (MCP 3) for in-vivo MPI in rats and analyzed dose requirements, sensitivity and detail resolution. 8 rats were examined using a preclinical MPI scanner (Bruker Biospin GmbH, Germany) equipped with a separate receive coil. MCP 3 and Resovist were administered intravenously (i.v.) into the rats’ tail veins at doses of 0.1, 0.05 and 0.025 mmol Fe/kg followed by serial MPI acquisition with a temporal resolution of 46 volumes per second. Based on a qualitative visual scoring system MCP 3–MPI images showed a significantly (P ≤ 0.05) higher image quality than Resovist-MPI images. Morphological features such as vessel lumen diameters (DL) of the inferior vena cava (IVC) and abdominal aorta (AA) could be assessed along a 2-cm segment in mesenteric area only after administration of MCP 3 at dosages of 0.1, 0.05 mmol Fe/kg. The mean DL ± SD estimated was 2.7 ± 0.6 mm for IVC and 2.4 ± 0.7 mm for AA. Evaluation of DL of the IVC and AA was not possible in Resovist-MPI images. Our results show, that MCP 3 provide better image quality at a lower dosage than Resovist. MCP 3-MPI with a clinically acceptable dose of 0.05 mmol Fe/kg increased the visibility of vessel lumens compared to Resovist-based MPI towards possible detection of vascular abnormalities such as stenosis or aneurysms, in vivo.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

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In vivo magnetic particle imaging: angiography of inferior vena cava and aorta in rats using newly developed multicore particles

Mohtashamdolatshahi

Kratz

Kosch

et al. 2020

Sci Rep

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Magnetic Particle Imaging: From Tracer Design to Biomedical Applications in Vasculature Abnormality

Xie,

Zhai,

Zhou

et al. 2023

Advanced Materials

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Magnetic particle imaging (MPI) is an emerging non‐invasive tomographic technique based on the response of magnetic nanoparticles (MNPs) to oscillating drive fields at the center of a static magnetic gradient. In contrast with magnetic resonance imaging (MRI), which is driven by uniform magnetic fields and projects the anatomic information of the subjects, MPI directly tracks and quantifies MNPs in vivo without background signals. Moreover, it does not require radioactive tracers and has no limitations on imaging depth. This review first introduces the basic principles of MPI and important features of MNPs for advanced imaging sensitivity, spatial resolution, and targeted biodistribution. The latest research on optimized MPI tracers is reviewed based on their material composition, physical properties, and surface modifications. Since all the imaging benefits have led to a series of promising biomedical applications, we also discuss recent relational practices of MPI in vascular abnormalities, including cardiovascular and cerebrovascular systems, and cancers. Finally, some considerations of obstructions and recent progress closely related to the clinical translation of MPI are summarized to provide possible direction for future research and development.This article is protected by copyright. All rights reserved

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Embracing Defects and Disorder in Magnetic Nanoparticles

2021

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Iron oxide nanoparticles have tremendous scientific and technological potential in a broad range of technologies, from energy applications to biomedicine. To improve their performance, single‐crystalline and defect‐free nanoparticles have thus far been aspired. However, in several recent studies, defect‐rich nanoparticles outperform their defect‐free counterparts in magnetic hyperthermia and magnetic particle imaging (MPI). Here, an overview on the state‐of‐the‐art of design and characterization of defects and resulting spin disorder in magnetic nanoparticles is presented with a focus on iron oxide nanoparticles. The beneficial impact of defects and disorder on intracellular magnetic hyperthermia performance of magnetic nanoparticles for drug delivery and cancer therapy is emphasized. Defect‐engineering in iron oxide nanoparticles emerges to become an alternative approach to tailor their magnetic properties for biomedicine, as it is already common practice in established systems such as semiconductors and emerging fields including perovskite solar cells. Finally, perspectives and thoughts are given on how to deliberately induce defects in iron oxide nanoparticles and their potential implications for magnetic tracers to monitor cell therapy and immunotherapy by MPI.

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MPI Phantom Study with A High-Performing Multicore Tracer Made by Coprecipitation

Cited by 17 publications

References 55 publications

In vivo magnetic particle imaging: angiography of inferior vena cava and aorta in rats using newly developed multicore particles

In vivo magnetic particle imaging: angiography of inferior vena cava and aorta in rats using newly developed multicore particles

Magnetic Particle Imaging: From Tracer Design to Biomedical Applications in Vasculature Abnormality

Embracing Defects and Disorder in Magnetic Nanoparticles

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