mPEGylated solanesol micelles as redox-responsive nanocarriers with synergistic anticancer effect

Qin, Benkai; Liu, Lei; Wu, Xiaohe; Liang, Fengguang; Hou, Tian; Pan, Yangyang; Song, Shiyong

doi:10.1016/j.actbio.2017.09.040

Cited by 33 publications

(17 citation statements)

References 38 publications

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“…Recently, Yao et al [8,9] have found that solanesol not only can induce HO-1 and Hsp70 expression, thereby mitigating alcohol-induced hepatocyte injury, but it also displays anti-inflammatory activity by inhibiting the production of inflammatory cytokines through the p38 and Akt signaling pathways. Moreover, Qin et al [10,11] have reported that mPEGylated solanesol micelles increase the oral bioavailability of CoQ 10 and serve as redox-responsive nanocarriers with synergistic anticancer effect.…”

Section: Introductionmentioning

confidence: 99%

RNA Sequencing Provides Insights into the Regulation of Solanesol Biosynthesis in Nicotiana tabacum Induced by Moderately High Temperature

Ning

Zhang

et al. 2018

Biomolecules

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Solanesol is a terpene alcohol composed of nine isoprene units that mainly accumulates in solanaceous plants, especially tobacco (Nicotiana tabacum). The present study aimed to investigate the regulation of solanesol accumulation in tobacco leaves induced by moderately high temperature (MHT). Exposure to MHT resulted in a significant increase in solanesol content, dry weight, and net photosynthetic rate in tobacco leaves. In MHT-exposed tobacco leaves, 492 and 1440 genes were significantly up- and downregulated, respectively, as revealed by RNA-sequencing. Functional enrichment analysis revealed that most of the differentially expressed genes (DEGs) were mainly related to secondary metabolite biosynthesis, metabolic pathway, carbohydrate metabolism, lipid metabolism, hydrolase activity, catalytic activity, and oxidation-reduction process. Moreover, 122 transcription factors of DEGs were divided into 22 families. Significant upregulation of N. tabacum 3-hydroxy-3-methylglutaryl-CoA reductase (NtHMGR), 1-deoxy-d-xylulose 5-phosphate reductoisomerase (NtDXR), geranylgeranyl diphosphate synthase (NtGGPS), and solanesyl diphosphate synthase (NtSPS) and significant downregulation of N. tabacum 1-deoxy-d-xylulose 5-phosphate synthase (NtDXS) and farnesyl diphosphate synthase (NtFPS) transcription upon MHT exposure were monitored by quantitative real-time PCR (qRT-PCR). This study indicated that solanesol accumulation in tobacco leaves can be manipulated through regulation of the environmental temperature and established a basis for further elucidation of the molecular mechanism of temperature regulation of solanesol accumulation.

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Section: Introductionmentioning

confidence: 99%

RNA Sequencing Provides Insights into the Regulation of Solanesol Biosynthesis in Nicotiana tabacum Induced by Moderately High Temperature

Ning

Zhang

et al. 2018

Biomolecules

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“…As shown in Figure 8C , compared with free DOX, the DOX-loaded micelles exhibited significantly reduced cytotoxicity on L-02 cells, which is probably due to their slower uptake of DOX-loaded micelles by L-02 cells. While, there was no significant difference in the cytotoxicity between the two DOX-loaded micelles, which could be attributed to the limited of acid environment in L-02 cells compared with tumor cells (Qin et al, 2017 ).…”

Section: Resultsmentioning

confidence: 99%

Hydrazone-Containing Triblock Copolymeric Micelles for pH-Controlled Drug Delivery

Liu

et al. 2018

Front. Pharmacol.

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In this study, the structure–activity relationship of amphiphilic block copolymer micelles as nanosized drug delivery system was revealed. Firstly, a biodegradable triblock polymers PEG-DiHyd-PLA containing hydrazone bond was synthesized through the ring-opening polymerization. In this method, PEG-DiHyd-Phenol was used as the initiator and L-lactide as the monomer. Then, the polymeric micelles were formed and used as nano-drug carriers with pH sensitivity. The structure and composition of the polymer were characterized by infrared (IR), nuclear magnetic resonance (1H-NMR), and gel permeation chromatography (GPC), we characterized the self-assembling process of the triblock polymers and the pH sensitivity of the micelles by the means of transmission electron microscopy (TEM), dynamic light scattering method (DLS). Doxorubicin (DOX) acts as the model drug, and we researched the capacities of drug loading and release in vitro of the micelles. MTT experiments showed that the blank micelles of PEG-DiHyd-PLA were not cytotoxic to tumor cells (HepG-2, MCF-7) and normal cell (L-02 cells), but the DOX loaded ones displayed more toxicity than the ones without hydrazone, which was consistent to the further confocal laser scanning microscopy and flow cytometry study.

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“…This might be explained by the rapid intracellular PTX release of the micellar system. More exactly, GSH in the cytoplasm of MCF-7 cells could facilitate the drug release from the PTX-loaded micelles, so as to enhance the antitumor effect of the drug [42]. It was inspiring that the cytotoxicity of PTX-loaded micelles against normal cells (PBMC cells) was much lower than that against cancer cells (MCF-7 cells).…”

Section: In Vitro Cytotoxicitymentioning

confidence: 99%

A Chitosan-Based Micellar System as Nanocarrier For the Delivery of Paclitaxel

et al. 2020

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In this study, a redox-sensitive chitosan derivative with modifications by cholesterol, sulfhydryl, and mPEG (mPEG-CS(SH)-CHO) was successfully synthesized and characterized. Due to its amphiphilicity, the conjugate could spontaneously form micelles in an aqueous environment. The optimized paclitaxel (PTX)-loaded mPEG-CS(SH)-CHO micelles, with a mean diameter of 158 nm, zeta potential of +26.9 mV, drug loading of 11.7%, and entrapment efficiency of 88.3%, were successfully prepared. The results of an XRD study demonstrated that PTX was loaded in the core of the micelles in a non-crystalline state. Inspiringly, the PTX-loaded micelles possessed excellent anticancer effect but low toxicity to the body. It can be concluded that the mPEG-CS(SH)-CHO micellar system is a promising drug delivery carrier for the controlled release of PTX.

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mPEGylated solanesol micelles as redox-responsive nanocarriers with synergistic anticancer effect

Cited by 33 publications

References 38 publications

RNA Sequencing Provides Insights into the Regulation of Solanesol Biosynthesis in Nicotiana tabacum Induced by Moderately High Temperature

RNA Sequencing Provides Insights into the Regulation of Solanesol Biosynthesis in Nicotiana tabacum Induced by Moderately High Temperature

Hydrazone-Containing Triblock Copolymeric Micelles for pH-Controlled Drug Delivery

A Chitosan-Based Micellar System as Nanocarrier For the Delivery of Paclitaxel

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