MPC-Based Prediction of Anti-Mutant Effectiveness of Antibiotic Combinations: In Vitro Model Study with Daptomycin and Gentamicin against Staphylococcus aureus
Abstract:To explore whether combined treatments with daptomycin and gentamicin can prevent the development of Staphylococcus aureus resistance, and whether the possible restriction is associated with changes in antibiotic mutant prevention concentrations (MPCs), the enrichment of daptomycin- and gentamicin-resistant mutants was studied by simulating 5-day single and combined treatments in an in vitro dynamic model. The MPCs of the antibiotics in the combination were determined at concentration ratios equal to the ratio… Show more
“…The contribution from Golikova et al [ 3 ] applied traditional one-compartment modeling to determine mutant prevention concentrations of anti-staphylococcal antibiotics when given in combination. Antimicrobial resistance development is a significant global issue and can limit the effectiveness of infectious disease treatments.…”
“…The contribution from Golikova et al [ 3 ] applied traditional one-compartment modeling to determine mutant prevention concentrations of anti-staphylococcal antibiotics when given in combination. Antimicrobial resistance development is a significant global issue and can limit the effectiveness of infectious disease treatments.…”
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