Mp89-08 Post-Finasteride Syndrome: Real or Imagined?

Abstract

determined diabetic rats randomly got intracavernous (IC) injection of phosphate buffer solution (PBS), ADSCs or MTs. Another eight normal rats equally received IC injection of PBS. MTs were generated with a hanging drop method and the injected cells were tracked in ADSCs and MTs injected rats. Four weeks after the treatments, intracavernous pressure (ICP), histopathological changes in corpus cavernosum (CC), and functional proteins were measured. Rat cytokine antibody array was used to detect ADSCs or MTs lysate.RESULTS: MTs expressed vascular endothelial growth factor (VEGF), nerve growth factor (NGF) and tumour necrosis factor-stimulated gene 6 (TSG-6). MTs injection had a higher retention than ADSCs injection and MTs treatment better improved ICP, neuronal nitric oxide synthase (nNOS) expression, smooth muscle and endothelial contents in diabetic rats, ameliorated local inflammation in CC.CONCLUSIONS: IC injection of MTs improves the erectile function and histopathological changes in streptozotocin-induced diabetic rats and appears to be more promising than traditional ADSCs. The underlying mechanisms involve increased cell retention accompanied with neuroprotection and anti-inflammatory behaviors of the paracrine factors.

Post-finasteride syndrome: a surmountable challenge for clinicians

“…Testosterone is converted into 17b-estradiol by the aromatase enzyme. To highlight the considerable controversies surrounding this syndrome, Butcher et al (182) in a presentation at the AUA, Post-Finasteride Syndrome: Real or Imagined?, offered summaries of their analyses of data from the US FDA Adverse Events Reporting System (FAERS) and concluded, ''whether or not PFS is real or imagined is not discernable within this context and database.'' The authors conclusion casted serious doubts on the existence of PFS, albeit, no concrete evidence was provided.…”

From organ injury to disability: a proposed model for 5-alpha reductase inhibitor syndrome

“…[1][2][3][4][5][6][7][8] Articles and conference presentations hint at paranormal phenomena with titles such as: "Post-Finasteride Syndrome: Real or Imagined?" 9 Three recent papers from leading lights in urology-strikingly similar in their design, findings and conclusions-have sown doubts about the validity of adverse event (AE) reports. 1,3,4 Doctors and researchers have ventured the following explanations for reports of PD-5ARI: ordinary depression, nocebo effect, psychogenic erectile dysfunction, mass psychogenic illness, distress and psychopathology associated with hair loss, dissatisfaction, advocacy group efforts, stimulated reporting and litigation interests.…”