Mp76-08 Serum Levels of Enclomiphene and Zuclomiphene in Hypogonadal Men on Long-Term Clomiphene Citrate Treatment

Abstract

Of 589 men who underwent RP, subjects reported use of at least one erectile aid at 2 years. Frequency of use, and effectiveness of erectile aids, is summarized in Table 1. Factors associated with responsiveness to ED treatment included age, number of comorbidities, baseline PSA, prostate volume, and D'Amico risk stratification. Effectiveness of oral PDE5i was the best predictor of erection quality, defined as erection firm enough for penetration, and sexual satisfaction two years after RP. Of the 140 men in whom PDE5i were ineffective, 35, 39, and 39 subjects tried IA, ICI, and/or VED, respectively; there was no significant difference in the effectiveness of these three aids in this subset of men. Only 4/140 subjects reported achieving an erection firm enough for penetration using these three aids. CONCLUSIONS: Almost all men seeking treatment for ED try PDE5i following surgery. Over 50% of these men report effectiveness of PDE5i 2 years following RP. In cases where PDE5i are ineffective, IA, ICI, and VED may be used for treatment of ED, but erection quality remains poor despite the use of these erectile aids.

Clomiphene citrate: the changing landscape

“…Because of the different biochemical properties of the two isomers, the study emphasizes on the development of pure enclomiphene isomer for treatment of hypogonadal men. 46 Edward D. Kim, Andrew McCullough and Jed Kaminetsky conducted a study to compare oral emclomiphene with topical testosterone gel and concluded that enclomiphene citrate consistently increased serum testosterone, lutienizing hormone and follicle stimulating hormone, restoring normal levels of serum testosterone and also maintained sperm concentrations in the normal range. Testosterone gel also restored total testosterone but sperm counts were not maintained.…”