Abstract:INTRODUCTION AND OBJECTIVES: Renal ischaemia reperfusion injury (IRI), is a major source of morbidity and mortality in hospitalised patients. Despite extensive research, there are no effective therapies against renal IRI, and patient outcomes have not improved. Our group have previously demonstrated that zinc (Zn) preconditioning (PC) protects the kidney against renal IRI in a sheep model. However, the mechanisms through which Zn exerts its effect are unknown. There are multiple processes involved in the patho… Show more
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