Mp699graft Survival in Kidney Transplant Expanded Criteria Donors: Analysis of Two Periods

López, Verónica; Cabello, Mercedes; Ruiz, Pedro; Alonso, J. Blasco; Hernández, Domingo

doi:10.1093/ndt/gfw200.23

Cited by 1 publication

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“…Graft survival after kidney transplantation has markedly improved over the years [ 1–3 ] most likely due to improved immunosuppressive treatment (IST), but in part, may be related to improved knowledge and medical care in general [ 4 ]. Multiple factors influence graft loss after kidney transplantation [ 5 ], some of which have been well-studied.…”

Section: Introductionmentioning

confidence: 99%

Sex-specific time trends of long-term graft survival after kidney transplantation – a registry-based study

Nasic,

Peters,

Stegmayr

et al. 2023

Renal Failure

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Background Sex-specific trends over time with respect to kidney graft survival have scarcely been described in earlier studies. The present study aimed to examine whether kidney graft survival differs between women and men over time. Methods This study was based on prospectively collected data extracted from a quality registry including all kidney transplant patients between January 1965 and September 2017 at the transplantation center of a university hospital in Sweden. The transplantation center serves a population of approximately 3.5 million inhabitants. Only the first graft for each patient was included in the study resulting in 4698 transplantations from unique patients (37% women, 63% men). Patients were followed-up until graft failure, death, or the end of the study. Death-censored graft survival analysis after kidney transplantation (KT) was performed using Kaplan-Meier analysis with log-rank test, and analysis adjusted for confounders was performed using multivariable Cox regression analysis. Results Median age at transplantation was 48 years (quartiles 36–57 years) and was similar for women and men. Graft survival was analyzed separately in four transplantation periods that represented various immunosuppressive regimes (1965-1985, 1986–1995, 1996–2005, and 2006–2017). Sex differences in graft survival varied over time (sex-by-period interaction, p = 0.026). During the three first periods, there were no significant sex differences in graft survival. However, during the last period, women had shorter graft survival ( p = 0.022, hazard ratio (HR) 1.71, 95% confidence interval (CI) 1.1–2.7, adjusted for covariates). Biopsy-proven rejections were more common in women. Conclusions In this registry-based study, women had shorter graft survival than men during the last observation period (years 2006–2017).

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Section: Introductionmentioning

confidence: 99%