Mp40-11 management of Indeterminate Small Testis Masses (Stms): A 10-Year Single Centre Experience

Abstract

resistance. Furthermore, protein expression profiles of selected proteins of the akt/mTOR signaling pathway demonstrated an upregulation of pAKT, p4EBP1 and pmTOR in both resistant cell lines compared to therapy-naïve cells. Therapeutic potential of this pathway was further corroborated by efficacy testing of everolimus.CONCLUSIONS: Resistance patterns and mechanisms were identified, emphasizing the involvement of the AKT/mTOR signaling pathway and paving the way for development of novel treatment strategies in PeCa. Targeting this pathway might prolong efficacy of therapeutic regimens or induce a re-sensitization of treatment-resistant PeCa cells.