MP39-15 YAP EXPRESSION PLAYS IMPORTANT ROLES IN MALIGNANT AGGRESSIVENESS BY REGULATING THE INFILTRATION OF CD57 ⁺ NATURAL KILLER CELLS, CD68 ⁺ MACROPHAGES, AND MAST CELLS AND THE EXPRESSION OF VEGF-A AND PD-L1 IN CLEAR CELL RENAL CELL CARCINOMA

Abstract

RESULTS: Among the three ccRCC datasets, 756 patients with ccRCC tumor samples were identified (N: TCC 104, CPTAC 111, TCGA 541). Eight distinct SVs were found to have high ccRCC prevalence and low prevalence in adjacent normal kidney tissue and non-ccRCC malignancies (Figure 1A). Genes with multiple distinct SVs were classified separately. The GAL3ST1-a and GAL3ST1-b SVs had the highest prevalence in ccRCC, as well as the highest read count per patient (Figure 1B). In the TCC ccRCC cohort, low read counts of SVs from the GAL3ST1 gene were associated with stage cM1.CONCLUSIONS: We identified eight novel SVs that are highly prevalent in ccRCC tumors and minimally prevalent in adjacent normal kidney tissue and other malignancies. Particularly striking were four distinct SVs affecting the the GAL3ST1 gene. These novel SVs warrant further investigation as potential biomarkers in ccRCC.