Mp38-16 the Significant Role of Depression in Elderly Bladder Cancer Patients

Abstract

INTRODUCTION AND OBJECTIVE: Our current study aims to determine the correlation between controlling nutritional status (CONUT) and prognostic nutritional index (PNI) and long term outcomes in bladder cancer patients.METHODS: A total of 302 bladder cancer patients who received a cystectomy from University Hospitals Cleveland Medical Center between 2007-2019 were evaluated. CONUT score was obtained based on total cholesterol, albumin, and lymphocyte count. PNI was calculated by utilizing the following formula: 10 Â the serum albumin value (g/dl) þ 0.005 Â the total lymphocyte count in peripheral blood (per mm3). Using inclusion/exclusion criteria, a total of 179 patients were included. We utilized Kaplan-Meier survival analyses to determine the correlation between CONUT and PNI and survival. PNI and CONUT association with upstaging was performed via multivariable regression analysis after adjusting for age, gender, chemotherapy status (y/n), smoking, Charlson Comorbidity Index.RESULTS: Patients with a PNI >50 (no evidence of malnourishment) had an Odds-Ratio (OR) of 0.416 (95% CI: 0.196-0.884, p[0.023) for upstaging of disease compared to patients with PNI <50, suggesting a protective effect against upstaging. When adjusted for age (OR[ 1.026.95%