Mp37-08 the Association Between Diabetes and Prostate Cancer-Specific Mortality Is Different in Obese and Non-Obese Men After Radical Prostatectomy: Results From the Search Database

Abstract

However, KHO35 of the same dose did not have antitumor effect on other CRPC cell lines, suggesting specific selectivity of KHO35 for NEPC cells. KHO35 inhibited the expression of NEPC-related markers in a dose-dependent manner. The time course changes in NEPC tumor growth were examined using NCI-H660 with KHO35. In vivo, KHO35 had an antitumor effect on NCI-H660 xenograft mice models. These results indicate that KHO35 has a significant antitumor effect on NCI-H660 in vivo as well as in vitro. LCeMS revealed an inhibitory effect of KHO35 on RNA transport and spliceosome pathways.CONCLUSIONS: We identified a candidate drug KHO35 that can convert NEPC signature in CRPC-adeno by reprograming the lineage plasticity. KHO35 could be a promising drug for treating NEPC.