Mp25-19 comparison of Complications, Operating Time and Costs in Double-Layered Hand-Sewn vs. Mechanical Stapled Ileo-Ileal Anastomosis During Radical Cystectomy

Abstract

greatest resulting reductions in standardized mean differences and variance ratios between groups. Counterfactual outcomes were generated using logistic regression to determine the average treatment effect of ACP incorporation. Standard errors and the 95% confidence intervals were calculated from 1,000 bootstrap samples.RESULTS: A total of 327 cases at our facility were reviewed. Twenty-three of 24 ACP cases were successfully matched to 245 of 303 non-ACP cases using a kernel-matching algorithm (Figure 1). Matching resulted in standardized mean differences below 0.1 for 14 of 16 NSQIP predictor variables and variance ratios of less than 2.0 for all NSQIP predictor variables. Following ACP incorporation, there was a raw SSI reduction of 5.7%, a raw UTI reduction of 5.6% and a raw increase in procedure duration of 38.4 minutes. The estimated treatment effect after modeling was a 4.1% reduction in SSI (p<0.02, CI 0.6% to 7.5%), with no significant effect on UTI incidence or procedure duration.CONCLUSIONS: Using a treatment effects model, the incorporation of an abdominal closure protocol was associated with a significant reduction in surgical site infection with minimal increase in surgical time.