Mp230synthetic Cannabinoid and Kidney

Abstract

Introduction and Aims: Synthetic cannabinoid (SCs) use has been increasing in Turkey parallel to the rest of the world. It is more commonly named as bonzai, jamaica, k2 or spice and is used illegally for pleasure and hallucinogenic effects. Here we presented six patients who were followed up in Nephrology clinic with acute kidney injury (AKI) due to synthetic cannabinoid usage in last six months . Methods: Single centre experience; Here we presented six patients who were followed up in Nephrology clinic with acute kidney injury (AKI) due to synthetic cannabinoid usage in last six months . Results: Six male patients aged between 28-42 years were admitted to the nephrology clinic, after presenting to the ER with nausea, vomiting and abdominal pain and whose laboratory results showed high levels of urea and creatinine. Clinical and laboratory findings in all six patients are summarized in Table 1. The most evident complaints of patients were nausea and vomiting. The patients declared that nausea-vomiting started approximately 10-16 hours before coming to the ER and approximately 2-4 hours after inhalation. All 6 cases have abdominal pain starting from the epigastric region and felt more severely in both lumbar regions. Metabolic alkalosis was observed in 4, normoacidemia in 2 patients. Kidney biopsies were performed in 2 of the cases (Case 3 and 5) revealed evidence of acute tubular necrosis, focal tubular atrophy, flattened and granulated epithelium and interstitial fibrosis. On the other hand; hypertrophic and global sclerotic glomerulies were observed. Vessels were unremarkable, with no significant staining on the immunofluorescence. Conclusions: SCs using is growing up daily, particularly in young generation and becoming a serious public health threat. In less than 6 months, a total of 6 cases were hospitalised in our clinic and unfortunately 4 of them (%66) became dependent on

Highly Sensitive Electrochemical Sensor Based on Pt Doped NiO Nanoparticles/MWCNTs Nanocomposite Modified Electrode for Simultaneous Sensing of Piroxicam and Amlodipine

“…Further, AML is prescribed for sick with diabetes, if they obtain heart related ailments that necessitate use to calcium channel blocker drugs. Different methods have been employed to determine AML in biological samples such as HPLC , gas chromatography (GC) , spectrophotometry and capillary electrophoresis , several electrochemical methods have been recently used to determine AML because of their many mentioned advantages .…”