Mp22-18 Identification of Novel Gene Expression Markers for Bladder Cancer Diagnostics

Алексеев, Б. Я.; Vorobyev, N. V.; Shegay, Peter; Zabolotneva, Anastasia; Русаков, И. Г.; Buzdin, Anton; Гайфуллин, Нуршат; Kovalchuk, Olga

doi:10.1016/j.juro.2014.02.866

Cited by 4 publications

(3 citation statements)

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“…Based on the Open Targets Platform, TFDP1 was related to various human diseases, including respiratory (LUAD and LUSC), thoracic, reproductive system, gastrointestinal, immune system, and endocrine system diseases. TFDP1 was overexpressed in breast and bladder cancer, confirmed by quantitative real-time polymerase chain reaction (qRT-PCR) and could be a potential biomarker [ 43 , 44 ]. Jibrim et al used real-time polymerase chain reaction (PCR) to evaluate TFDP1 expression levels and found that TFDP1 expression was underexpressed in women’s endometrium [ 45 ].…”

Section: Discussionmentioning

confidence: 99%

Comprehensive Analysis Reveals the Potential Roles of Transcription Factor Dp-1 in Lung Adenocarcinoma

Song

2023

World J Oncol

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Background Transcription factor Dp-1 (TFDP1) was overexpressed and interacted with other genes to impact multiple signaling pathways in various human cancers. However, there is less research about the TFDP1 specific roles in lung adenocarcinoma (LUAD). Methods We first explored TFDP1 expression levels and relative diseases from a pan-cancer perspective using the ONCOMINE, TIMER, and Open Targets Platform databases. Then, we used UALCAN, GEPIA 2, TCGA-LUAD data, and Kaplan-Meier plotter to examine TFDP1 clinicopathological features and prognosis in LUAD patients. Genomic alterations and DNA methylation analysis were performed by cBioPortal and MethSurv, respectively. Then, we used a cancer single-cell state atlas (CancerSEA) to find TFDP1 functions at a single-cell resolution. LinkedOmics was used to find TFDP1 coexpressed genes, biological processes, and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. Then, Gene Set Cancer Analysis (GSCA) was used to examine the drug resistence of TFDP1 in LUAD. Results We found that TFDP1 was overexpressed in most human cancers and related to various diseases, including LUAD. Moreover, LUAD patients with high TFDP1 expression levels might be significantly associated with individual cancer stages and have a poor prognosis. Multivariate analysis revealed that the American Joint Committee on Cancer (AJCC) pathologic stage, AJCC stage T, and AJCC stage N were the independent prognostic factors. LUAD patients with TFDP1 alterations suggested poor overall survival (OS), and disease-free survival (DFS), while hypermethylation might lead to a good prognosis. TFDP1 and its coexpressed genes were enriched in multiple signaling pathways and biological processes involved in the cell cycle, spliceosome, and DNA replication. Furthermore, TFDP1 was strongly positively related to the half-maximal inhibitory concentration (IC50) values of multiple drugs. Conclusions In summary, TFDP1 was a possible biomarker and potential therapeutic target for LUAD patients.

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Section: Discussionmentioning

confidence: 99%

Comprehensive Analysis Reveals the Potential Roles of Transcription Factor Dp-1 in Lung Adenocarcinoma

Song

2023

World J Oncol

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“…Previously, KIFC1 was reported to be highly expressed in several types of cancer including ovarian cancer ( Pawar et al, 2014 ), breast cancer ( Pannu et al, 2015 ), bladder cancer ( Alekseev et al, 2014 ), lung cancer ( Grinberg-Rashi et al, 2009 ), among others ( Chan, 2011 ). However, the exact mechanism of KIFC1 overexpression remains unclear ( Pannu et al, 2015 ).…”

Section: Analysis Of Clinical Datamentioning

confidence: 99%

Role of motor proteins in human cancers

Ibrahim

Balah

Hassan

et al. 2022

Saudi Journal of Biological Sciences

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“…It is reported that KIFC1 is abundantly and widely expressed in cancer cells of the ovary [22], breast [23], bladder [24], lung [25], kidney [26] and other cancers [26]. The special status of KIFC1 in cancer cells is, therefore, well established.…”

Section: Evidence For Applicability Of Kifc1-related Systems In Anti-mentioning

confidence: 99%

KIFC1: a promising chemotherapy target for cancer treatment?

Xiao

Yang

2016

Oncotarget

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The kinesin motor KIFC1 has been suggested as a potential chemotherapy target due to its critical role in clustering of the multiple centrosomes found in cancer cells. In this regard, KIFC1 seems to be non-essential in normal somatic cells which usually possess only two centrosomes. Moreover, KIFC1 is also found to initiatively drive tumor malignancy and metastasis by stabilizing a certain degree of genetic instability, delaying cell cycle and protecting cancer cell surviving signals. However, that KIFC1 also plays roles in other specific cell types complicates the question of whether it is a promising chemotherapy target for cancer treatment. For example, KIFC1 is found functionally significant in vesicular and organelle trafficking, spermiogenesis, oocyte development, embryo gestation and double-strand DNA transportation. In this review we summarize a recent collection of information so as to provide a generalized picture of ideas and mechanisms against and in favor of KIFC1 as a chemotherapy target. And we also drew the conclusion that KIFC1 is a promising chemotherapy target for some types of cancers, because the side-effects of inhibiting KIFC1 mentioned in this review are theoretically easy to avoid, while KIFC1 is functionally indispensable during mitosis and malignancy of multi-centrosome cancer cells. Further investigations of how KIFC1 is regulated throughout the mitosis in cancer cells are needed for the understanding of the pathways where KIFC1 is involved and for further exploitation of indirect KIFC1 inhibitors.

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Mp22-18 Identification of Novel Gene Expression Markers for Bladder Cancer Diagnostics

Cited by 4 publications

References 0 publications

Comprehensive Analysis Reveals the Potential Roles of Transcription Factor Dp-1 in Lung Adenocarcinoma

Comprehensive Analysis Reveals the Potential Roles of Transcription Factor Dp-1 in Lung Adenocarcinoma

Role of motor proteins in human cancers

KIFC1: a promising chemotherapy target for cancer treatment?

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