Mp139study of Urinary Podocin as Marker of Lupus Nephritis Activity

ElShaarawy, Abdel Bassit; Behairy, Maha; Bawady, Somia; Elsayed, Fatma Elzahraa

doi:10.1093/ndt/gfx164.mp139

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“…As regarding, the observation in this study that podocin is significantly correlated to LN activity, it is also supported by the result of ElShaarawy et al (24) as they proved that urinary podocin was highly sensitive and specific in relation to LN activity and may be used clinically as prognostic marker in LN patients. This concept is supported by the data of Sabino et al (23) ,who studied podocyturia by indirect immunofluorescence technique by utlilizing primary antibodies to podocytes (anti podocin, synaptopodin, nephrin).They found that podocin positive cells were remarkably associated with the LN severity.…”

Section: Discussionsupporting

confidence: 86%

Clinical Significance of Urine Podocyte Messenger Ribonucleic Acids in Idiopathic Nephrotic Syndrome and Lupus Nephritis Patients

Elokely¹,

Waked²,

Shemis³

et al. 2022

The Egyptian Journal of Hospital Medicine

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Introduction: Podocytes are specific epithelial cells that surround the outside of the glomeruli's basement membrane (GBM). They play a significant role in glomerular function. This study aimed to detect the presence of podocyte in idiopathic nephrotic syndrome and lupus nephritis patients, and to correlate them with the proteinuria levels. Methods: Patients were divided to three groups (patients with idiopathic nephrotic syndrome, patients with lupus nephritis and, healthy controls. Quantification of podocyte mRNA proteins in urinary sediment by real time PCR was performed to all groups. Results: For those who had nephrotic syndrome showed significant increase in the alpha actin 4 value (p= 0.001) and significant decrease in the value of synaptopodin and podoclyxin in relation to controls (p= 0.001). The level of urinary expression of mRNA of podocytes correlated positively to renal function tests and estimated glomerular filtration rate between nephrotic and control groups. The reverse occurred with proteinuria. A significant rise in the alpha actin 4 value, podocin and synaptopodin in comparison with control (p= 0.001). Podocalyxin was decreased significantly (p=0.021). There was a statistically significant difference, when comparing renal function tests and estimated glomerular filtration rate between LN and control group. Also, an increase in the value of podocin in active group relative to control and non-active groups (p= 0.001 and p= 0.007, respectively). Conclusion: Significant increase in level of mRNA of alpha actin in nephrotic syndrome, while mRNA podocin, synaptopodin and alpha actin were increased in LN, with podocin could mark increased activity of the disease.

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Section: Discussionsupporting

confidence: 86%