Mp016hypercalcemia and Nephrocalcinosis Induced by "Pump and Pose" Intramuscular Injection

Chiri, Rami; Kim, Gabriel; Chelala, Dania; Azar, Hiba

doi:10.1093/ndt/gfx160.mp016

Cited by 8 publications

(4 citation statements)

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“…In regards to hypercalcemia, Chiri et al reported a case similar to ours in 2017 [ 2 ], where a young bodybuilder developed foreign body granulomatosis after Synthol injection, leading to calcitriol mediated hypercalcemia and subsequent pancreatitis and nephrocalcinosis.…”

Section: Discussionsupporting

confidence: 55%

“…Systemic complications with the use of Synthol are rarely reported. Foreign body granulomatosis with calcitriol mediated hypercalcemia has been only reported a single time previously [ 2 ], and here we report a second case. What makes this case unique is the presence of pulmonary granulomatosis, discovered incidentally during workup, theorized to be secondary to hematologic spread of the injected material.…”

Section: Introductionmentioning

confidence: 63%

“…Systemic complications after Synthol injection are, however, rare. Hypercalcemia has only been previously reported once with Synthol use [ 2 ], but pulmonary complications have never been reported before. This is part of what makes the above-presented case unique.…”

Section: Discussionmentioning

confidence: 99%

“…Reported complications after Synthol injection include pain, muscle deformity, and local ulceration [ 2 ]. Systemic complications with the use of Synthol are rarely reported.…”

Section: Introductionmentioning

confidence: 99%

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Synthol systemic complications: Hypercalcemia and pulmonary granulomatosis. A case report

Alimoradi

Chahal

El-Rassi

et al. 2021

Annals of Medicine &Amp; Surgery

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Introduction Synthol injection for body contouring has been used by bodybuilders for some time. We report two extremely rare systemic complications; pulmonary granulomatosis and hypercalcemia, in a woman who has received Synthol injections for buttocks augmentation. Presentation of case The case discussed in this report is of a 36-year-old lady who presented for severe hypercalcemia and nephrocalcinosis. Subsequent workup revealed granulomas in the buttocks and in the lungs. Upon questioning, it was discovered that she had received Synthol injection for buttocks augmentation a few months earlier. Labs were consistent with calcitriol mediated hypercalcemia, a phenomenon observed in granulomatous diseases. A diagnosis of foreign body granulomatosis with pulmonary migration and secondary hypercalcemia was made. The patient was started on prednisone and showed an initial positive response. Discussion Reported complications of Synthol include pain, muscle deformity, and ulceration at the injection site. Hypercalcemia secondary to foreign body granulomatosis after Synthol injection has been reported only once previously, and here we report a second case. The hypercalcemia is thought to be calcitriol mediated, where overexpression of CYP27B1 in the macrophages forming the granulomas leads to pathological extrarenal calcitriol production. Pulmonary granulomatosis, theorized to be secondary to hematologic migration of the injected material, has never been reported previously with Synthol use. Conclusion Synthol injection for body contouring may be a cause of extensive local and pulmonary foreign body granulomatosis leading to calcitriol mediated hypercalcemia. History of cosmetic injections should not be disregarded during history taking.

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Section: Discussionsupporting

confidence: 55%

Section: Introductionmentioning

confidence: 63%

Section: Discussionmentioning

confidence: 99%

“…Reported complications after Synthol injection include pain, muscle deformity, and local ulceration [ 2 ]. Systemic complications with the use of Synthol are rarely reported.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Synthol systemic complications: Hypercalcemia and pulmonary granulomatosis. A case report

Alimoradi

Chahal

El-Rassi

et al. 2021

Annals of Medicine &Amp; Surgery

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“A slippery slope”: a scoping review of the self-injection of unlicensed oils and fillers as body enhancement

Brennan

Overbye

Hout

et al. 2021

Performance Enhancement & Health

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Antiretroviral Laboratory Monitoring and Implications for HIV Clinical Care in the Era of COVID-19 and Beyond

York

Fisher

Malladi

et al. 2021

AIDS Research and Human Retroviruses

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Conclusion.In the complex environment of a pediatric HIV specialty clinic, most PLWH mounted Ab responses to 4v HPV that were durable. H18 was least immunogenic. Patients with higher HIV VL were less likely to seroconvert for all types and were more likely to sero-revert.Disclosures. All Authors: No reported disclosures Antiretroviral Laboratory Monitoring and Implications for HIV Clinical Care in the Era of COVID-19 and Beyond

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Mp016hypercalcemia and Nephrocalcinosis Induced by "Pump and Pose" Intramuscular Injection

Cited by 8 publications

References 0 publications

Synthol systemic complications: Hypercalcemia and pulmonary granulomatosis. A case report

Synthol systemic complications: Hypercalcemia and pulmonary granulomatosis. A case report

“A slippery slope”: a scoping review of the self-injection of unlicensed oils and fillers as body enhancement

Antiretroviral Laboratory Monitoring and Implications for HIV Clinical Care in the Era of COVID-19 and Beyond

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