Moxifloxacin resistance is prevalent among Bacteroides and Prevotella species in Greece

The antibiotic susceptibility rates of 363 clinical Bacteroides fragilis group isolates collected from 17 centers in Argentina during the period from 2006 to 2009 were as follows: piperacillin-tazobactam, 99%; ampicillin-sulbactam, 92%; cefoxitin, 72%; tigecycline, 100%; moxifloxacin, 91%; and clindamycin, 52%. No metronidazole resistance was detected in these isolates during this time period. Resistance to imipenem, doripenem, and ertapenem was observed in 1.1%, 1.6%, and 2.3% of B. fragilis group strains, respectively. B. fragilis species showed a resistance profile of 1.5% to imipenem, 1.9% to doripenem, and 2.4% to ertapenem. This is the first report of carbapenem resistance in Argentina. The cfiA gene was present in 8 out of 23 isolates, all of them belonging to the B. fragilis species and displaying reduced susceptibility or resistance to carbapenems (MICs > 4 g/ml). Three out of eight cfiA-positive isolates were fully resistant to carbapenems, while 5 out of 8 isolates showed low-level resistance (MICs, 4 to 8 g/ml). The inhibition by EDTA was a good predictor of the presence of metallo-␤-lactamases in the fully resistant B. fragilis strains, but discrepant results were observed for low-level resistant isolates. B. fragilis was more susceptible to antimicrobial agents than other Bacteroides species. Bacteroides vulgatus species was the most resistant to ampicillin-sulbactam and piperacillin-tazobactam, and B. thetaiotaomicron/ovatus strains showed the highest level of resistance to carbapenems, with an unknown resistance mechanism. B. vulgatus and the uncommon non-Bacteroides fragilis species were the most resistant to moxifloxacin, showing an overall resistance rate of 15.1%.

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“…The overall moxifloxacin susceptibility rate remained higher than that reported by Snydman et (10,19,20,26).…”

Section: Discussioncontrasting

confidence: 67%

“…Antimicrobial resistance rates vary in different countries and also among the different medical centers within the same country (2,15,20). Therefore, both periodic local and national susceptibility studies and the evaluation of new therapeutic agents are necessary to provide data for an appropriate empirical antimicrobial therapy (18).…”

mentioning

confidence: 99%

First National Survey of Antibiotic Susceptibility of the Bacteroides fragilis Group: Emerging Resistance to Carbapenems in Argentina

Fernández-Canigia¹,

Litterio²,

Legaria³

et al. 2012

Antimicrob Agents Chemother

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“…In this study, the moxifloxacin resistance rates were 11% for B. fragilis and 18% for other B. fragilis group organisms. These rates were slightly higher than the 7 to 9% reported in Taiwan (11) but lower than those in Greece (14) and the United States (16 to 75% and 26 to 55%, respectively) (17). Overall, Prevotella, Porphyromonas, and Fusobacterium isolates are more susceptible than B. fragilis group organisms (7).…”

mentioning

confidence: 75%

Antimicrobial Susceptibility Patterns for Recent Clinical Isolates of Anaerobic Bacteria in South Korea

Lee

Park

Kim

et al. 2010

Antimicrob Agents Chemother

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We determined the antimicrobial susceptibilities of 255 clinical isolates of anaerobic bacteria collected in 2007 and 2008 at a tertiary-care hospital in South Korea. Piperacillin-tazobactam, cefoxitin, imipenem, and meropenem were highly active ␤-lactam agents against most of the isolates tested. The rates of resistance of Bacteroides fragilis group organisms and anaerobic Gram-positive cocci to moxifloxacin were 11 to 18% and 0 to 27%, respectively.

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“…Combinations of b-lactams with b-lactamase inhibitors, as well as carbapenems, were found to exhibit the highest antimicrobial activity against Prevotella spp. overall, whereas some studies have highlighted the emergence of metronidazole resistance [54,196,[212][213][214][215][216][217]. However, susceptibility profiles vary significantly by bacterial species, geographic origin and source of isolation.…”

Section: Antimicrobial Susceptibility and Resistance Mechanisms Of Prevmentioning

confidence: 99%

New Insights into Prevotella Diversity and Medical Microbiology

Alauzet¹,

Marchandin

Lozniewski³

2010

Future Microbiol.

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In light of recent studies based on cultivation-independent methods, it appears that the diversity of Prevotella in human microbiota is greater than was previously assumed from cultivation-based studies, and that the implication of these bacteria in several human diseases was unrecognized. While some Prevotella taxa were found during opportunistic infections, changes in Prevotella abundance and diversity were discovered during dysbiosis-associated diseases. As member of the microbiota, Prevotella may also be considered as a reservoir for resistance genes. Greater knowledge on Prevotella diversity, as well as new insights into its pathogenic potential and implication in dysbiosis are expected from the use of human microbe identification microarrays, from whole-genome sequence analyse, and from the NIH Human Microbiome Project data. New approaches, including molecular-based methods, could contribute to improve the diagnosis of Prevotella infections.

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Moxifloxacin resistance is prevalent among Bacteroides and Prevotella species in Greece

Cited by 35 publications

References 12 publications

First National Survey of Antibiotic Susceptibility of the Bacteroides fragilis Group: Emerging Resistance to Carbapenems in Argentina

First National Survey of Antibiotic Susceptibility of the Bacteroides fragilis Group: Emerging Resistance to Carbapenems in Argentina

Antimicrobial Susceptibility Patterns for Recent Clinical Isolates of Anaerobic Bacteria in South Korea

New Insights into Prevotella Diversity and Medical Microbiology

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