Moxifloxacin detection based on fluorescence resonance energy transfer from carbon quantum dots to moxifloxacin using a ratiometric fluorescence probe

Li, Zhiwen; Zhang, Jiyue; Sun, Qiyao; Shi, Wenwen; Tao, Tingxian; Fu, Yingqiang

doi:10.1039/d1nj05961k

Cited by 11 publications

(6 citation statements)

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“…31 Compared with the above-mentioned methods, CQDs have attracted enthusiastic attention because of their excellent photoluminescence properties, unique fluorescent properties, simple preparation, easy modification, low toxicity, high stability and fluorescence quantum yield. [32][33][34][35] Notably, CQDs have been successfully utilized for selective and sensitive detection in various metal cations, biological protein, environmental pollution and many other substances. [36][37][38][39][40][41] Although fluorescence detection by CQDs has achieved progress, few examples of CQDs have been applied for SeO 3 2À detection, but most utilized microwave-assisted, pyrolysis, multi-step reactions to prepare CQDs, which have a cumbersome preparation process, small yield, and low quantum yield, and none of them have been deeply studied and applied in biological sample detection.…”

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confidence: 99%

Ultrasensitive and selective fluorescence recognition of selenite by o-phenylenediamine functionalized carbon quantum dots

et al. 2022

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Section: àmentioning

confidence: 99%

Ultrasensitive and selective fluorescence recognition of selenite by o-phenylenediamine functionalized carbon quantum dots

et al. 2022

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“…Figure 4 shows the absorption spectra of the ligand, Moxi.HCl, the Eu(III)-(DOCA) 2 complex, and Eu(III)-(DOCA) 2 -Moxi.HCl complex, respectively. The absorption spectra of Moxi.HCl exhibits two absorption bands [35]. Upon the addition of the Eu(III)-(DOCA) 2 complex to Moxi.HCl, a blue shift of the absorption band of the drug from 296 nm to 291 nm with decreasing absorbance revealed the binding between the complex and the additional ligand.…”

Section: The Stoichiometry Of Probementioning

confidence: 99%

Sensitive Determination of Moxifloxacin HCl in Pharmaceuticals or Human Plasma Using Luminescence or Eye Vision

et al. 2022

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A new probe based on the complex of 1,2 dihydro-2-oxoquinoloine-4-carboxylic acid (DOCA) as a ligand with Europium (III) ion was developed for the quantitation of Moxifloxacin HCl (Moxi.HCl) in pharmaceuticals and human plasma using a luminescence method. The metal to ligand ratio of the complex is 1:2 as determined by a Job plot. The determination of Moxi.HCl is based on static quenching of the luminescence of the probe upon coordination of Moxi.HCl. The negative value for ΔG proves that this reaction is spontaneous. The calibration curve was constructed based on a Stern–Volmer equation and the quantitation range was 0.05–80 µg ml−1. This is low enough to determine the drug in blood plasma, even hours after administration, which is not feasible with the methods published so far. The LOD was 15 ng ml−1. The accuracy of the method was demonstrated by good recoveries of spiking experiments in tablets, ophthalmic eyedrops and human blood plasma, where the mean recovery was 99% with RSDs below 5%. The method was validated by closely matching concentrations of the drug found in all these real samples by HPLC. Additionally, Moxi.HCl can be assessed semi-quantitatively by eye vision upon excitation with a UV lamp at 365 nm by a gradual color shift from red to blue with increasing concentrations of Moxi.HCl.

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“…Carbon quantum dots (CQDs) are novel carbon nanomaterials containing water‐soluble functional groups, such as hydroxyl and carboxyl groups (<10 nm in size), on their surfaces. In recent years, CQDs have been developed as fluorescent nanomaterials [14–16] . Compared with organic fluorescent dyes, CQDs have excellent light stability, good water solubility, high‐intensity fluorescence light, good bleaching performance, and emission and excitation wavelengths that are easy to control.…”

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confidence: 99%

A Fluorescent Self‐Absorption Method for Detection of Captopril using Carbon Quantum Dots

Zhou

et al. 2022

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A hydrothermal method for preparing water‐soluble carbon quantum dots (CQDs) was studied using the citric acid and thiourea. The CQDs have high fluorescence Intensity, high photoluminescence stability and uniform size. Their average size is 5 nm. Their maximum excitation and emission wavelengths are 364 and 452 nm, respectively. divalent copper ions can quench the fluorescence of CQDs and captopril can interact with divalent copper ions to form complexes, the complexes can further reduce the fluorescence of CQDs due to self‐absorption, and there was a linear relationship between the ratio of the fluorescence intensities before and after adding captopril and the captopril concentration. A novel, simple, and environmentally friendly fluorescence detection method for captopril was established. It has been successfully used for captopril detection in captopril tablets.

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Moxifloxacin detection based on fluorescence resonance energy transfer from carbon quantum dots to moxifloxacin using a ratiometric fluorescence probe

Abstract: In this paper, a new method of ratio fluorescence detection of moxifloxacin (MOX) is developed based on carbon quantum dots (CQDs). In short, through a one-step hydrothermal method, using soluble...

Cited by 11 publications

References 36 publications

Ultrasensitive and selective fluorescence recognition of selenite by o-phenylenediamine functionalized carbon quantum dots

Ultrasensitive and selective fluorescence recognition of selenite by o-phenylenediamine functionalized carbon quantum dots

Sensitive Determination of Moxifloxacin HCl in Pharmaceuticals or Human Plasma Using Luminescence or Eye Vision

A Fluorescent Self‐Absorption Method for Detection of Captopril using Carbon Quantum Dots

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