Moxifloxacin-dependent Torsades de Pointes

Tiryakioğlu, Selma Kenar; Tiryakioğlu, Osman; Aktürk, Faruk; Mehmetoğlu, Ertuğrul; Kumbay, Ethem

doi:10.5152/akd.2011.145

Cited by 2 publications

(1 citation statement)

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“…(b) The monitor reading showed the presence of TdP. converted to VF, [3][4][5] and cardiac pacing was needed in three of the others.…”

Section: Discussionmentioning

confidence: 99%

Moxifloxacin dependent torsades de pointes in a bradycardic patient with multiple risk factors

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2015

Turk Gogus Kalp Dama

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ÖZUzamış QT aralığı ile ilişkilendirilen Torsades de pointes (TdP) nadir fakat ölümcül bir aritmidir. İlaçla indüklenmiş QT uzamasının en yaygın nedeni gecikmiş düzeltici potasyum akımlarının hızlı komponentinin inhibisyonudur. Gecikmiş düzeltici potasyum akımlarının hızlı komponentinin inhibisyonu miyositlerdeki potasyumu bloke ederek repolarizasyonu geciktirir. Bu yazıda; kadın cinsiyeti, organik kardiyak hastalık ve bradikardiyi içeren TdP risk faktörleri olan bir hasta sunuldu. 400 mg/gün oral moksifloksasin uygulamasının beşinci gününde hasta ventriküler fibrilasyona ilerleyen bir TdP epizodu geçirdi ve başarıyla defibrile edildi.Anah tar söz cük ler: Kardiyak cerrahi; moksifloksasin; torsades de pointes. ABSTRACTTorsades de pointes (TdP), which is associated with a prolonged QT interval, is a rare but potentially fatal arrhythmia. The most common cause of drug-induced QT prolongation is inhibition of the rapidly activating component of the delayed rectifier potassium current. Rapidly activating component of the delayed rectifier potassium current inhibition delays repolarization by blocking the potassium in myocytes. In this article, we present a patient who had TdP risk factors including female sex, organic cardiac disease, and bradycardia. On the fifth day of 400 mg/day oral moxifloxacin administration, the patient had an episode of TdP, which progressed to ventricular fibrillation, and was successfully defibrillated.

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“…(b) The monitor reading showed the presence of TdP. converted to VF, [3][4][5] and cardiac pacing was needed in three of the others.…”

Section: Discussionmentioning

confidence: 99%