Moxifloxacin-associated neutropenia

Berk, Velı; Demiraslan, Hayati; Berk, Elife; Karaca, Halıt; İnanç, Mevlüde; Bozkurt, Oktay; Özkan, Metin

doi:10.3109/00365548.2012.738937

Cited by 7 publications

(6 citation statements)

References 9 publications

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“…Our patient had findings consistent with moxifloxacin-induced neutropenia. All the three cases which have been reported earlier also had similar presentation[234] [Table 1]. Though reports of ciprofloxacin and norfloxacin-induced neutropenia are available, we could not find any report of cytopenia following levofloxacin administration.…”

mentioning

confidence: 63%

Moxifloxacin-associated Neutropenia in a Patient Planned for Renal Transplantation

et al. 2019

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confidence: 63%

Moxifloxacin-associated Neutropenia in a Patient Planned for Renal Transplantation

et al. 2019

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“…On the fourth day of the treatment, leukopenia and neutropenia worsened, so moxifloxacin was withdrawn and oral clarithromycin was started. On the next days both leukopenia and neutropenia improved [2].…”

Section: Discussionmentioning

confidence: 92%

“…Moxifloxacin, inhibiting ATP-dependent enzymes topoisomerase II (DNA gyrase) and topoisomerase IV, is a fourth generation widely used fluoroquinolone antibiotic [1,2]. Moxifloxacin with potent activity against gram-positive, gram-negative and atypical bacteria is generally being used for the treatment of community-acquired pneumonia (CAP) and widely used in urinary system, digestive system and other infections [1,3,4].…”

Section: Introductionmentioning

confidence: 99%

Moxifloxacin-induced neutropenia in 26-year-old man

Ati̇k

İspir

Aytekin

et al. 2018

J Infect Dev Ctries

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Moxifloxacin is a fourth generation widely used fluoroquinolone antibiotic. There are three cases of moxifloxacin-induced neutropenia reported in the literature and we report the fourth case. A 26-year-old man with pneumonia was treated with moxifloxacin because of penicillin allergy. On the second day of therapy, leukopenia [White blood cell (WBC) count 2.7×10³/μL] and neutropenia (neutrophils 1.21×10³/μL) occurred. Rothia mucilaginosa was isolated in sputum culture. On the fourth day of hospitalization moxifloxacin treatment was stopped and clarithromycin 500 mg PO twice daily was started. Leukopenia and neutropenia resolved one day after discontinuation of moxifloxacin that WBC and neutrophil count rose 4.5×10³/μL and 1.97×10³/μL, respectively. On the sixth day of hospitalization, WBC and neutrophil count was 4.3×10³/μL and 2.29×10³/μL, respectively. The immunomodulatory effects of moxifloxacin may result in the changes of WBC count like leukopenia with neutropenia. Moxifloxacin induced neutropenia may be more common and is an important adverse effect. More observational studies about safety profiles of moxifloxacin are needed.

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“…Again, viral/fungal infection were excluded, and neutropenia resolved with discontinuation of moxifloxacin. 5 …”

Section: Discussionmentioning

confidence: 99%

A Case of Severe Neutropenia From Short-Term Exposure to Moxifloxacin

Chen

Buren

2017

Journal of Investigative Medicine High Impact Case Reports

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Moxifloxacin is commonly prescribed in the inpatient and outpatient management of community-acquired pneumonia and other common infections. We report a case of a 76-year-old man who developed severe neutropenia after several days of treatment for community-acquired pneumonia. The patient had a history of alcohol abuse; however, there were no other offending medications prescribed, and a thorough laboratory workup for other possible causes of neutropenia was negative. The patient’s neutrophils and white blood count responded quickly to cessation of fluoroquinolones. This case highlights the importance of identifying patients that might be at high risk for neutropenia that may need closer monitoring on this commonly prescribed medication.

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Moxifloxacin-associated neutropenia

Cited by 7 publications

References 9 publications

Moxifloxacin-associated Neutropenia in a Patient Planned for Renal Transplantation

Moxifloxacin-associated Neutropenia in a Patient Planned for Renal Transplantation

Moxifloxacin-induced neutropenia in 26-year-old man

A Case of Severe Neutropenia From Short-Term Exposure to Moxifloxacin

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