Moxibustion intervention for patients with ankylosing spondylitis: A study Protocol for a pilot randomized controlled trial

Xu, Xiao; Chen, Zhen; Wang, Hongyuan; Li, Li; Lü, Jiafeng; Yan, Min; Ding, Cai-Yan; Sun, Zhi-Qin; Sun, Qiuhua

doi:10.1016/j.eujim.2019.02.005

Cited by 3 publications

(2 citation statements)

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“…Several clinical trials and systematic reviews suggested that moxibustion as an adjuvant therapy in combination with NSAIDs or biological agents may exert positive effects on AS patients. 6 , 7 , 8 Potential mechanisms have been suggested that inhibition of non-specific endochondral ossification of spine 9 , regulating immune function 10 , anti-inflammation, anti-oxidant, anti-muscle degenerative and cartilage-protective effect. 11 …”

Section: Introductionmentioning

confidence: 99%

Metabolomic analysis of biochemical changes in the tissue and urine of proteoglycan-induced spondylitis in mice after treatment with moxibustion

Shi

Wang

et al. 2021

Integrative Medicine Research

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Background Moxibustion is widely used in East Asian countries to manage the symptom of rheumatic diseases. The aim of this study was to identify potential metabolic profiles of moxibustion on relieving ankylosing spondylitis (AS) mice through UHPLC-Q-TOF/MS metabolomic study. Methods Thirty-two female Balb/c mice were randomized into healthy control (HC), AS model, moxibustion at acupuncture points (MA) in AS model, and moxibustion at non-acupuncture points (MNA) AS model groups. Moxibustion was administered daily at GV4, bilateral BL23 and bilateral ST36 acupuncture points for four weeks in the MA group. The overall health status, the thickness of hind paws and the tissue concentrations of IL-1β, PGE 2 , IL-6 and TNF-α were assessed. The UHPLC-Q-TOF/MS was used to explore the perturbations of endogenous metabolites in tissue and urine of AS model mice intervened by moxibustion. Results Compared with the AS group, the overall health status was significantly improved after 4-week moxibustion intervention ( p < 0.05) . The results also showed that MA significantly reduced the levels of paw thickness and decreased the levels of four cytokines in the tissue ( p < 0.01). Thirty-seven endogenous metabolites identified by the OPLS-DA were considered to be contributing to therapeutic effects of moxibustion. Moreover, metabolic pathway analysis further revealed that the identified metabolites were mainly involved in TCA cycle, Lipid metabolism, Amino Acid metabolism, Intestinal flora metabolism and Purine metabolism. Conclusions UHPLC-Q-TOF/MS based metabolomics approach, as a novel and powerful tool, can help us to gain the insights into potential mechanisms of action of moxibustion for AS.

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Section: Introductionmentioning

confidence: 99%

Metabolomic analysis of biochemical changes in the tissue and urine of proteoglycan-induced spondylitis in mice after treatment with moxibustion

Shi

Wang

et al. 2021

Integrative Medicine Research

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“…Manipulative and manual therapy (MMT), a costly and time-consuming CAM technique, is popular among Asian patients. Different styles of MMT exist for the management of musculoskeletal system diseases,[ 17 18 19 ] of which gua sha is one of the most common. [20] Gua sha therapy is also known as cao gio, khoud lam, and ga sal in different Asian countries.…”

Section: Introductionmentioning

confidence: 99%

Gua sha therapy for chronic low back pain

Wang

et al. 2020

Medicine

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Background: Non-specific chronic low back pain (LBP) is a debilitating disease that profoundly impacts patients’ daily physical function and quality of life. Gua sha therapy, as an easy-to-use and noninvasive complementary modality, has been widely used clinically in patients with non-specific chronic LBP. The aim of this study is to test the potential benefits and harms of gua sha therapy on patients with non-specific chronic LBP. Methods: Ten English databases, 3 Korean databases, 6 Chinese databases, 1 Japanese database, and 2 Brazilian databases will be searched from their inception to September 2019. Randomized controlled trials will be included if gua sha therapy was used as the sole treatment or as a part of combination therapy with other treatments in patients with non-specific chronic LBP. Two reviewers will independently extract the data and assess the methodological quality using the Cochrane criteria for risk of bias. The meta-analysis will be performed using Review Manager 5.3 software. Results: The findings of this systematic review will be published in a peer-reviewed journal. Conclusion: This systematic review will provide more evidence regarding the clinical usage of gua sha therapy for non-specific chronic LBP. Trial registration number: CRD42019134567

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Moxibustion therapy in Chinese patients with ankylosing spondylitis: A randomized controlled pilot trial

Wang

et al. 2019

European Journal of Integrative Medicine

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Moxibustion intervention for patients with ankylosing spondylitis: A study Protocol for a pilot randomized controlled trial

Cited by 3 publications

References 51 publications

Metabolomic analysis of biochemical changes in the tissue and urine of proteoglycan-induced spondylitis in mice after treatment with moxibustion

Metabolomic analysis of biochemical changes in the tissue and urine of proteoglycan-induced spondylitis in mice after treatment with moxibustion

Gua sha therapy for chronic low back pain

Moxibustion therapy in Chinese patients with ankylosing spondylitis: A randomized controlled pilot trial

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