Moving toward the Inclusion of Epigenomics in Bacterial Genome Evolution: Perspectives and Challenges
Iacopo Passeri,
Francesca Vaccaro,
Alessio Mengoni
et al.
Abstract:The universality of DNA methylation as an epigenetic regulatory mechanism belongs to all biological kingdoms. However, while eukaryotic systems have been the primary focus of DNA methylation studies, the molecular mechanisms in prokaryotes are less known. Nevertheless, DNA methylation in prokaryotes plays a pivotal role in many cellular processes such as defense systems against exogenous DNA, cell cycle dynamics, and gene expression, including virulence. Thanks to single-molecule DNA sequencing technologies, g… Show more
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