Movement-related potentials associated with bilateral simultaneous and unilateral movements recorded from human supplementary motor area

Ikeda, Akio; Lüders, Hans; Shibasaki, Hiroshi; Collura, Thomas F.; Burgess, Richard C.; Morris, Harold H.; Hamano, Toshiaki

doi:10.1016/0013-4694(95)00086-e

Cited by 99 publications

(54 citation statements)

References 52 publications

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“…In contrast EEG studies from the scalp show widespread potentials in frontal and parietal areas Sasaki, 1989, Rosahl andKnight, 1995). The focal nature of the activations is, however, confirmed in the intracranial studies (Ikeda et al, 1995(Ikeda et al, , 1996Hamano et al, 1997;Lamarche et al, 1995). These studies further demonstrated that there are many focal areas which become active when a CNV protocol is used.…”

Section: Discussionmentioning

confidence: 91%

“…The second slow component, called the late CNV, begins 1.5 to 2 s before S2 and has its maximum 200 to 300 ms prior to S2. Studies with intracranial electrodes, in both man and animals, have demonstrated that multiple cortical and subcortical brain areas are involved in the CNV generation (Nakamura et al, 1988;Ikeda et al, 1995Ikeda et al, , 1998Hamano et al, 1997;Lamarche et al, 1995). In these studies, however, only the activity in the very local area where electrodes were placed can be identified.…”

Section: Introductionmentioning

confidence: 99%

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Neuromagnetic Localization of CMV Generators Using Incomplete and Full-Head Biomagnetometer

Dammers¹,

Ioannides

2000

NeuroImage

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Contingent magnetic variation (CMV) data were recorded in three healthy male subjects using a 2 ؋ 37 biomagnetometer system. The experiment was repeated for one of the subjects using a 151 whole-head biomagnetometer; the same auditory GO/NOGO choice reaction time paradigm as in the first experiment was used, extended to include repetitions of identical runs and additional control conditions. Magnetic field tomography was applied to the averaged data of each subject, for each run and condition (e.g., GO/NOGO). An independent estimate of the current density in the brain was obtained every few milliseconds. The slow components were emphasized by integrating the square of the current density vector, pixel by pixel, revealing in each subject activity in the auditory cortex, sensorimotor cortex, inferior prefrontal area, and posterior inferior parietal area. The intersubject variability was large, but looking across subjects the auditory and sensorimotor cortex (which were best covered by the two probes) were consistently identified in each subject as contributing to the generation of the early and late slow CMV components. These findings were confirmed by the whole-head single-subject experiment, in which slow activity was also identified in the supplementary motor area (SMA) and posterior cingulate cortex (PCC), areas very likely missed in the first experiment because of the limited view of the twin system. The PCC and particularly the SMA activations were substantially reduced when identical runs were repeated.

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Section: Discussionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Neuromagnetic Localization of CMV Generators Using Incomplete and Full-Head Biomagnetometer

Dammers¹,

Ioannides

2000

NeuroImage

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“…Backaveraging of midline EEG reveals a slow, negative potential termed the Bereitschaftspotential (BP) that begins 1-3 s before the onset of self-paced movement (Kornhuber and Deecke, 1965;Barrett et al, 1986). Studies using subdural electrodes have shown that the supplementary motor area (SMA) and contralateral primary sensorimotor cortex (Ikeda et al, 1995) are involved in generating the BP. This was confirmed with functional magnetic resonance imaging (fMRI) studies (Thickbroom et al, 2000;Cunnington et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Involvement of the Basal Ganglia and Cerebellar Motor Pathways in the Preparation of Self-Initiated and Externally Triggered Movements in Humans

Purzner

Paradiso²,

Cunic³

et al. 2007

J. Neurosci.

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The subthalamic nucleus (STN) is part of the cortico-basal ganglia (BG)-thalamocortical circuit, whereas the ventral lateral nucleus of the thalamus (VL) is a relay nucleus in the cerebello-dentato-thalamocortical (CTC) pathway. Both pathways have been implicated in movement preparation. We compared the involvement of the STN and VL in movement preparation in humans by recording local field potentials (LFPs) from seven patients with Parkinson's disease with deep-brain stimulation (DBS) electrodes in the STN and five patients with tremor and electrodes in VL. LFPs were recorded from DBS electrodes and scalp electrodes simultaneously while the patients performed self-paced and externally cued (ready, go/no-go) movements. For the self-paced movement, a premovement-related potential was observed in all patients from scalp, STN (phase reversal, five of six patients), and VL (phase reversal, five of five patients) electrodes. The onset times of the potentials were similar in the cortex, STN, and VL, ranging from 1.5 to 2 s before electromyogram onset. For the externally cued movement, an expectancy potential was observed in all patients in cortical and STN electrodes (phase reversal, six of six patients). The expectancy potential was recorded from the thalamic electrodes in four of five patients. However, phase reversal occurred only in one case, and magnetic resonance imaging showed that this contact was outside the VL. The cortico-BG-thalamocortical circuit is involved in the preparation of both self-paced and externally cued movements. The CTC pathway is involved in the preparation of self-paced but not externally cued movements, although the pathway may still be involved in the execution of these movements.

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“…However, the supplementary motor cortex (SMA) has been implicated in bimanual integration in animals [7,54] and humans [8,20,29]. One goal of our study was to see whether a simple bimanual tapping task can be adapted to a fMRI analysis, so that putative asymmetrical activations can be observed in the primary and supplementary motor cortices in humans.…”

Section: Introductionmentioning

confidence: 99%

fMRI study of bimanual coordination

et al. 2000

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Eleven right-handed subjects performed uni-and bimanual tapping tasks. Hemodynamic responses as measured with functional magnetic resonance imaging (fMRI) in the primary somato-motor cortex (SMC) showed that during bimanual activity the SMC contralateral to the hand taking the faster rate was more strongly activated than the SMC contralateral to hand taking the slower rate. There were no asymmetries; left SMC activation during the right fast/left slow tapping condition was comparable to the right SMC activation during the left fast/right slow condition. A given SMC showed similar activation levels for bimanual and unimanual activity (i.e. left SMC activation for right fast/left slow was similar to left SMC activation for the right fast unimanual condition). In contrast, a given supplementary motor area (SMA) showed signi®cantly more activation for the bimanual than for the unimanual activity. In addition, an asymmetry was observed during bimanual activities: during the right fast/left slow activity, the left SMA showed more activation than the right SMA, but during the left fast/right slow activity, the right SMA was not signi®cantly more activated than the left SMA. For unimanual activities, a clear rate e ect (greater activation for faster rate) was seen in the SMC but not in the SMA. #

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Movement-related potentials associated with bilateral simultaneous and unilateral movements recorded from human supplementary motor area

Cited by 99 publications

References 52 publications

Neuromagnetic Localization of CMV Generators Using Incomplete and Full-Head Biomagnetometer

Neuromagnetic Localization of CMV Generators Using Incomplete and Full-Head Biomagnetometer

Involvement of the Basal Ganglia and Cerebellar Motor Pathways in the Preparation of Self-Initiated and Externally Triggered Movements in Humans

fMRI study of bimanual coordination

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