Movement-related modulation of neural activity in human basal ganglia and its L -DOPA dependency: recordings from deep brain stimulation electrodes in patients with Parkinson's disease

Foffani, Guglielmo; Pesenti, A.; Bianchi, Anna Maria; Chiesa, Valentina; Baselli, Giuseppe; Caputo, E.; Tamma, Filippo; Rampini, Paolo; Egidi, M.; Locatelli, Marco; Barbieri, S.; Scarlato, G.

doi:10.1007/s100720200089

Cited by 136 publications

(97 citation statements)

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“…Although PD increases the average power of beta oscillations, moment-to-moment oscillation strength varies with voluntary movement and movement cues (Brucke et al 2012;Doyle et al 2005;Kuhn et al 2004;Kuhn et al 2006;Leventhal et al 2012;Levy et al 2002;Liu et al 2008;Priori et al 2002;Williams et al 2003). Over the long term, however, reflex blinks are uncorrelated with the temporal variations in oscillation strength associated with voluntary movement.…”

Section: Discussionmentioning

confidence: 99%

Effects of subthalamic deep brain stimulation on blink abnormalities of 6-OHDA lesioned rats

Kaminer

Thakur

Evinger

2015

Journal of Neurophysiology

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Kaminer J, Thakur P, Evinger C. Effects of subthalamic deep brain stimulation on blink abnormalities of 6-OHDA-lesioned rats. J Neurophysiol 113: 3038 -3046, 2015. First published February 11, 2015 doi:10.1152/jn.01072.2014.-Parkinson's disease (PD) patients and the 6-hydroxydopamine (6-OHDA) lesioned rat model share blink abnormalities. In view of the evolutionarily conserved organization of blinking, characterization of blink reflex circuits in rodents may elucidate the neural mechanisms of PD reflex abnormalities. We examine the extent of this shared pattern of blink abnormalities by measuring blink reflex excitability, blink reflex plasticity, and spontaneous blinking in 6-OHDA lesioned rats. We also investigate whether 130-Hz subthalamic nucleus deep brain stimulation (STN DBS) affects blink abnormalities, as it does in PD patients. Like PD patients, 6-OHDA-lesioned rats exhibit reflex blink hyperexcitability, impaired blink plasticity, and a reduced spontaneous blink rate. At 130 Hz, but not 16 Hz, STN DBS eliminates reflex blink hyperexcitability and restores both short-and long-term blink plasticity. Replicating its lack of effect in PD patients, 130-Hz STN DBS does not reinstate a normal temporal pattern or rate to spontaneous blinking in 6-OHDA lesioned rats. These data show that the 6-OHDA lesioned rat is an ideal model system for investigating the neural bases of reflex abnormalities in PD and highlight the complexity of PD's effects on motor control, by showing that dopamine depletion does not affect all blink systems via the same neural mechanisms.

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Section: Discussionmentioning

confidence: 99%

Effects of subthalamic deep brain stimulation on blink abnormalities of 6-OHDA lesioned rats

Kaminer

Thakur

Evinger

2015

Journal of Neurophysiology

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“…A dissociation between beta oscillatory LFPs and the clinical symptoms was also observed by Priori et al (2004), who showed that anticholinergic drug orphenadrine improved rigidity and tremor but also increased beta oscillatory activity. Dopaminergic medication and active movements are known to decrease STN beta synchronization (Brown et al 2001;Foffani et al 2005;Kuhn et al 2004;Levy et al 2002;Marsden et al 2001b;Priori et al 2002Priori et al , 2004 and deep brain stimulation in the STN may alleviate PD symptoms by disrupting this oscillatory activity (Brown et al 2004;Filali et al 2004;Jahanshahi et al 2000;Lozano et al 2002). It was previously hypothesized that dopamine action on the striatum acts as a filter for cortical input to the STN (Doyle et al 2005;Magill et al 2001Magill et al , 2004Sharott et al 2005).…”

Section: Discussionmentioning

confidence: 99%

Beta Oscillatory Activity in the Subthalamic Nucleus and Its Relation to Dopaminergic Response in Parkinson's Disease

Weinberger

Mahant²,

Hutchison³

et al. 2006

Journal of Neurophysiology

523

383

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. Beta oscillatory activity in the subthalamic nucleus and its relation to dopaminergic response in Parkinson's disease. J Neurophysiol 96: 3248 -3256, 2006. First published September 27, 2006 doi:10.1152/jn.00697.2006. Recent studies suggest that beta (15-30 Hz) oscillatory activity in the subthalamic nucleus (STN) is dramatically increased in Parkinson's disease (PD) and may interfere with movement execution. Dopaminergic medications decrease beta activity and deep brain stimulation (DBS) in the STN may alleviate PD symptoms by disrupting this oscillatory activity. Depth recordings from PD patients have demonstrated beta oscillatory neuronal and local field potential (LFP) activity in STN, although its prevalence and relationship to neuronal activity are unclear. In this study, we recorded both LFP and neuronal spike activity from the STN in 14 PD patients during functional neurosurgery. Of 200 singleand multiunit recordings 56 showed significant oscillatory activity at about 26 Hz and 89% of these were coherent with the simultaneously recorded LFP. The incidence of neuronal beta oscillatory activity was significantly higher in the dorsal STN (P ϭ 0.01) and corresponds to the significantly increased LFP beta power recorded in the same region. Of particular interest was a significant positive correlation between the incidence of oscillatory neurons and the patient's benefit from dopaminergic medications, but not with baseline motor deficits off medication. These findings suggest that the degree of neuronal beta oscillatory activity is related to the magnitude of the response of the basal ganglia to dopaminergic agents rather than directly to the motor symptoms of PD. The study also suggests that LFP beta oscillatory activity is generated largely within the dorsal portion of the STN and can produce synchronous oscillatory activity of the local neuronal population.

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“…DA transmission desynchronizes slow rhythms and induces fast-wave oscillations within the BG-thalamocortical circuits (Brown & Marsdan, 1998;Brown, 2003;Lee et al, 2004;Sharott et al, 2005). It also promotes a greater autonomy of BG neural patterns from a strict cortical control, blocking the spread of cortical synchronous oscillations into the BG (Marsden et al, 2001;Priori et al, 2002;Williams et al, 2002;Heimer et al, 2002;Cassidy et al, 2002;Goldberg et al, 2002;Magill et al, 2004;Sharot et al, 2005) (Fig. 4A).…”

Section: Da Modulation Of Global Field Dynamicsmentioning

confidence: 99%

Behavioral functions of the mesolimbic dopaminergic system: An affective neuroethological perspective

Alcaro

Huber

Panksepp

2007

Brain Research Reviews

497

289

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The mesolimbic dopaminergic (ML-DA) system has been recognized for its central role in motivated behaviors, various types of reward, and, more recently, in cognitive processes. Functional theories have emphasized DA's involvement in the orchestration of goal-directed behaviors, and in the promotion and reinforcement of learning. The affective neuroethological perspective presented here, views the ML-DA system in terms of its ability to activate an instinctual emotional appetitive state (SEEKING) evolved to induce organisms to search for all varieties of life-supporting stimuli and to avoid harms.A description of the anatomical framework in which the ML system is embedded is followed by the argument that the SEEKING disposition emerges through functional integration of ventral basal ganglia (BG) into thalamocortical activities. Filtering cortical and limbic input that spread into BG, DA transmission promotes the "release" of neural activity patterns that induce active SEEKING behaviors when expressed at the motor level. Reverberation of these patterns constitutes a neurodynamic process for the inclusion of cognitive and perceptual representations within the extended networks of the SEEKING urge. In this way, the SEEKING disposition influences attention, incentive salience, associative learning, and anticipatory predictions.In our view, the rewarding properties of drugs of abuse are, in part, caused by the activation of the SEEKING disposition, ranging from appetitive drive to persistent craving depending on the intensity of the affect. The implications of such a view for understanding addiction are considered, with particular emphasis on factors predisposing individuals to develop compulsive drug seeking behaviors.

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Movement-related modulation of neural activity in human basal ganglia and its L -DOPA dependency: recordings from deep brain stimulation electrodes in patients with Parkinson's disease

Cited by 136 publications

References 1 publication

Effects of subthalamic deep brain stimulation on blink abnormalities of 6-OHDA lesioned rats

Effects of subthalamic deep brain stimulation on blink abnormalities of 6-OHDA lesioned rats

Beta Oscillatory Activity in the Subthalamic Nucleus and Its Relation to Dopaminergic Response in Parkinson's Disease

Behavioral functions of the mesolimbic dopaminergic system: An affective neuroethological perspective

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